RE: PARP12 Nov 2022 08:00
From Endpoints
AstraZeneca and Merck executives are now raising concerns about how the IRA will impact cancer drug development moving forward as the clock for negotiations begins with the first approved indication.
On an investor call yesterday (this week), AstraZeneca CEO Pascal Soriot said that his company may no longer launch new cancer drugs in the US unless it’s for a large enough indication to keep that clock from starting too soon.
“There is a disincentive to start with small indications,” Soriot said on the call, adding:
That’s mostly true for oncology, where if you have to start with a third-line indication, patients would benefit from this, but we may not do it in the future or not launch in the U.S. We may launch elsewhere in the world, but not launch in the U.S. until we have approval for a larger indication, because the clock starts as soon as you get approval. So, that’s that. Those are really negative factors that are real problems with this.