AstraZeneca - Poster at ATSToday 15:31
Impressive!
RATIONALE 129Xe magnetic resonance imaging (MRI) is sensitive to abnormalities in lung ventilation, microstructure and gas transfer, and may help to phenotype patients with clinical features of both asthma and chronic obstructive pulmonary disease(COPD).
- In patients with normal TLco and normal Kco, MRI gas exchange (red blood cell/gas) was significantly reduced in asthma+COPD (n=35) compared with asthma (n=67) and in COPD (n=10) compared with asthma.
CONCLUSIONS129Xe MRI metrics were significantly different between patients diagnosed with asthma, asthma+COPD and COPD. Patients with asthma had lower ventilation heterogeneity, smaller acinar dimensions and greater gas exchange compared with patients with asthma+COPD and COPD
- 129Xe MRI metrics distinguished between diagnostic sub-groups of patients with normal pulmonary function tests .
I really hope the FDA take studies like this into consideration when approving Gas Exchange rather than running further Clinical Trials.
Only a matter of time!