Charles Jillings, CEO of Utilico, energized by strong economic momentum across Latin America. Watch the video here.
U.S. Patent granted for dynamic cardiopulmonary blood flow imaging with Xenon MRI
New patent expands the utility of hyperpolarised Xenon MRI in the diagnosis and monitoring of diseases of the pulmonary vasculature
Great RNS - this is only going one way
Gas Exchange = $$$$$$$$$$$’ers
Agreed Big Slick, with the fund raise coming, im surprised we have not be on the weekly agenda for the likes of Investor Meet Company meetings or doing similar types of promotion.
Can only hope the management have bigger things going on in the background
Nice one JJ7.
Yes, i think you are right that the Gas Exchange approval could be expedited.
There are so many trials going on and all are proving the technology works in this space, I think approval in 2025 has got a real chance.
Thanks for this JJ7, fully agree with you.
I have seen comms from the company with regard to the Gas Exchange (which I would happily share with anybody). It is going to be game changing.
I notice on the Gas Exchnage Trial page the estimated end date has come into August 2026, not a huge amount of time in the grand scheme of things.
I like how animated CVJ gets on the Proactive update when he talks about Gas Exchange
https://youtu.be/cTmRMGlsKSo?si=3I8qTcT886Uf3nvH
No links JJ7 but the endorsement section of LinkedIn has a very interesting new European based company (I don’t think it’s appropriate to put the name on BB’s without evidence) but I did some research on the company last night and it looks a great match to what polx are trying to do.
Also the person doing the liking and their closest peers are all respiratory and imagining
One of them is a global monster very active in the respiratory space, they are also very involved in parterships and licensing and it’s not the AstraZeneca endorsement
In the last day there has been some very interesting new companies endorsing Polarean on their social media pages.
There seems to be things happening in Europe IMO.
Cluster analysis to identify long COVID phenotypes using 129Xe magnetic resonance imaging
Taken from the full PDF report - https://erj.ersjournals.com/content/erj/63/3/2302301.full.pdf
Long COVID impacts ∼10% of people diagnosed with coronavirus disease 2019 (COVID[1]19), yet the pathophysiology driving ongoing symptoms is poorly understood. We hypothesised that 129Xe magnetic resonance imaging (MRI) could identify unique pulmonary phenotypic subgroups of long COVID. Therefore, we evaluated…Ventilation… and…Gas Exchange…measurements with cluster analysis to generate imaging-based phenotypes.
Conclusions
In conclusion, we demonstrate four unique long COVID phenotypes defined by 129Xe MRI metrics, with distinct functional MRI and corresponding clinical characteristics. Such differences were otherwise…Not… evident in the total long COVID group compared with COVID-negative and fully recovered post-COVID participants,…Especially… using PFTs and CT. These four clusters reveal distinct ( patho-)physiological changes that can be potential targets for therapy. Although a relatively new technology, 129Xe MRI is now approved for clinical use in the UK and USA [31], providing new clinical opportunities for improved characterisation of respiratory diseases [38] and targeting of therapeutics for patients with long COVID.
Future work can build from this foundation towards personalised medicine to evaluate the biological underpinnings of 129Xe MRI signatures of long COVID clusters, and to determine their disease trajectories and responses to therapy
Nice!
couldn’t agree more big slick.
we need to get to break even asap. i feel conversion of the 15 research sites and a couple of new sites will get us there no problem.
that should fairly value the company at around £100m
then it’s on the gas exchange, get that approved and you can 5 times that valuation on the day.
i have done some research on what the current reimbursement is for the gas exchange equivalent and it is big $$$$.
polx will make a huge impact in this market as the current standard is appalling - 6 minute walks up and down hospital corridors with a stop watch etc!
we will be ****t1ng cash by 2030
im happy to pick up shares under 10p and stick them in the bottom drawer
loads to play for here.
gla
Agreed Big Slick more clarity would be good, but we won’t get it as it’s an Amati issue not a polarean issue.
The wording in the RNS leads me to believe it is not a conspiracy:
We are considering the Company's strategic options in the light of ongoing challenges in the AIM market and the resultant performance issues faced by the Company
the resultant performance issues faced by the Company says it all - no conspiracy there in my view
i would happily join your party john :)
however, i do feel for amati here, they have backed the company well but clearly there is something wrong structurally and financially and polx happen to be at the **** end off it dragging the sp down to 4p - ludicrous!
Thanks unhooked.
Jeez, I feel for them, looks like they will be out by the end of the day… another 1m odd gone through
On Cue, RNS from Amati this morning!
The last sentence,
‘and the resultant performance issues faced by the Company’. - Ouch
The Board of Amati AIM VCT plc (the "Company") confirms that it has, in conjunction with the Company's investment manager, Amati Global Investors Limited (the "Investment Manager"), been considering the Company's strategic options in the light of ongoing challenges in the AIM market and the resultant performance issues faced by the Company.
PS - Amphion had to sell because they went bust!
Amati are clearly not going to go bust but imo it makes zero financial sense to be selling to Nukem at 5p unless they need the money urgently!
I have it on good authority that Amati are a forced seller because they have redemptions to meet.
If you look at their fund size in recent years, investors are leaving them.
I feel for them as they have put in a lot of effort here over the last 5 years. Apart from Amphion years ago, Amati are the only company I can ever remember releasing a TR-1!
Once they are out the share price will rise.
All non dilutive funding
And don’t forget the £3.5m Enterprise Investment Scheme
You heard it hear first:
- a £3/4m one off payment from Nukem will result in a long term Exclusive Deal to supply the isotope globally
- £4/5m from Bracco for the rights to set up a JV. Europe first then Asia.
- check this page on the Bracco website on how they do business globally
https://www.bracco.com/bracco-worldwide
- following Gas Exchange approval Bracco will buy the company
‘Through its controlled company, Bracco Imaging, the Bracco Group operates all over the world, either directly or indirectly through branches, joint-ventures, partnerships, or distribution and agency agreements’
GLA
Excellent interview from CVJ
https://youtu.be/bylX3crjtgs?si=J1P-Oh_6xtCeWWSX
Those who understand the company will know where this is going!
GLA
It depends on what you class as fiction?
The details and dates of the XCHANGE trial and the 6-12 year olds group have come direct from the CEO which appears more facts than fiction to me!
Agreed PJM an RNS is needed soon however it wouldn’t surprise me if we do not hear anything until the details of the XCHANGE Trial and 6-12’s year old’s is agreed with the FDA.
FWIW – It feels like the company are waiting on a few things:
- They need to understand how much the XCHANGE Trial is going to cost before being able to raise. I feel the funding of the trail may come from a Heart Foundation rather that equity.
I notice the BHF and American Heart Society have been sponsors of recent XE-129 Cardiology based Trials.
AS you know, the XCHANGE Trial is the absolute long term game changer for the company - so PLOX will take time to get it right!
- Another milestone they may be waiting for is the approval for the 6-12 year olds. They already give the to 6 – 12 year olds in trials so they know it has got a good chance of approval.
They will definitely not be raising at 6p, more like 20 – 30p if approved!
IMO this approval would blow any Ventilation competitor out of the water because you cannot give Lung CT scans to kids! Long term this is $$$$$’s for POLX
Both these decisions are due in the next 4 months so why raise now when we have got two major decisions to come, and some possible further sales?
All ifs and buts, but one thing is for sure, more comms from the company would be good!!