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Exclusive: Hardman & Co Investor Forum - Severn Trent, Calculus Capital, Volta Finance, Residential


Scancell Holdings Share Chat (SCLP)



Share Price: 6.40Bid: 6.00Ask: 6.80Change: 0.00 (0.00%)No Movement on Scancell Hldgs
Spread: 0.80Spread as %: 13.33%Open: 6.25High: 6.40Low: 6.25Yesterday’s Close: 6.40


Share Discussion for Scancell Holdings


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CHELSEA7
Posts: 36,290
Premium Chat Member
Opinion:Strong Buy
Price:6.40
RNS Today
Today 20:24
Welcome to Marin Diggle, the shares admitted to AIM today, total now 465m and a M/Cap of £29.8m. Well i suggested a return to £30m when stuck at £20m, next target for me £50m and a Share price of 10.5p.

News coming every day, the last two as a result of Thursdays news, much more to come IMHO, and agin welcome Martin Diggle.
 
Hargreaves Lansdown
CHELSEA7
Posts: 36,290
Premium Chat Member
Opinion:Strong Buy
Price:6.40
OXB
Today 20:18
And article on OXB, relevant to our dual shareholder Vulpers was tring to find out more over the weekend as to who has joined them re Holdings and the effect they had once they took their stake. Heres the link for anybody in a research mood, a view of the company from Hardman Research and a M/Cap now of £560m odd , not to be sniffed at.

https://outlook.live.com/mail/inbox/id/AQMkADAwATY0MDABLWIxZWYtNTUAMWQtMDACLTAwCgBGAAADCqFlxDNj106vpRjC6Gx45wcAxNXyOELO5EuKlnVUZmPdfQAAAgEMAAAAR3H%2FmTBPW0af7Chl86KgHQACILesywAAAA%3D%3D
CHELSEA7
Posts: 36,290
Premium Chat Member
Opinion:No Opinion
Price:6.40
RE: Revising Tired T Cells
Today 19:57
Which in itself comes back to the immune system, low exercise regimes and low metabolic rates/ I stick to 1000 calories a day, but that in itself is hardly boosting the immune system
RayPointer
Posts: 1,216
Opinion:No Opinion
Price:6.40
RE: Revising Tired T Cells
Today 19:43
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4837657/

This article tends to suggest that metabolism plays a big role in maintaining the effectiveness of the TCell population.
Biontech may have a handle on this in their TCR technology. Clone only the fittest TCells.
CHELSEA7
Posts: 36,290
Premium Chat Member
Opinion:No Opinion
Price:6.40
RE: Revising Tired T Cells
Today 19:38
Seeing more articles like this, can only presume ii is indeed playing that role in riviving tired cells.

Till tomorrow eh, 8 days to srart of trial!!!
RayPointer
Posts: 1,216
Opinion:No Opinion
Price:6.40
RE: Revising Tired T Cells
Today 19:32
An interesting article C7.
It would be interesting to know if activation of TCells actually plays a role in revival of tired cells. Do activated cells get a new lease of life and is this also passed on in clonal expansion?
RuckRover
Posts: 2,140
Opinion:No Opinion
Price:6.40
RE: Ruck
Today 19:16
I lived in Evesham, Worcestershire.
I agree, there is much to be positive about. No need to be picky about everything. ATB
inanaco
Posts: 29,521
Opinion:No Opinion
Price:6.40
worth a watch
Today 19:09
CHELSEA7
Posts: 36,290
Premium Chat Member
Opinion:No Opinion
Price:6.40
RE: Ruck
Today 18:58
Thanks Ruck, couldn"t have been more genuine in my post.

Where was you living whem screening wasn"t until 60 years of age?

Yes Ruck, there are many cases the other way, just doesn"t mean it must carry on, I was trying not to proportion blame, just ease up on it.

Glad we are on the same page with that, pretty sure we all are, the best results will be comingwhen these variable will come into play, I agree with Ratts post a few days ago saying the next five years progress will far exceed that we have seen in the last five, and for sure the five before that, GL buddy.
RuckRover
Posts: 2,140
Opinion:No Opinion
Price:6.40
RE: Ruck
Today 18:40
C7, early detection is crucial. Screening for colon cancer starts at 55 in some counties. Where I lived, it wasn’t until 60. This probably cost my wife her life.

This afternoon, I found out that my colleague who was diagnosed with breast cancer two years ago has found her husband has colon cancer. This was found through screening - where they live it starts at 55. Due to this, he has a good chance of making a complete recovery.

I’m sorry you feel I am goading Inan, but if you review the history you will find I made a genuine reply to a question and he went on the attack.

Get a good nights rest.
CHELSEA7
Posts: 36,290
Premium Chat Member
Opinion:Strong Buy
Price:6.40
Ruck
Today 18:24
""The debate is whether there are in fact "hard to treat" cancers as I stated originally or whether they are all the same as Inanaco has tried to argue all afternoon."""

Is it really?? Not IMHO

Reading back on the BB (again), it seems the debate is actually a continuation of the feud between you and Inanaco, which is a shame as the topic is very real, and from now my lung cancer is certainly ""untreatable"" which is down not so much because of the cancer, but as Inanaco mentioned other complaints like heart failure, to name one, has made it impossible to have treatments that could matter. Will certainly be interesting to see what my cause of death will be, taking into account so many diagnosed conditions down as untreatable.

As much as i agree with a lot of what you say, I do believe you goad inanaco unnecessarily, I would rather enjoy what he has to offer than finding faults with how he says things, and once again the most worthy posts are written by crumbs with no personals distracting him.

See what you can do guys, we got 170 share chats on Thursday, heard from many posters for the first time in ages, and the share has a positive feel, why destroy at and back a couple of losers who are posting to incite only?

Glad we ended up the day level, just for myself and not trading, I called Mondays share action correct and said that buyers would return sub 6.50. Seems to have been the way, and tomorrow have a feeling the bid will let go and spread shortened as we lead up to trial.

See what you can do guys, I hate to say the filter button is an option, but perhaps it is here, there are many of us fed up with the pettiness at a time when so much could happen for all our good.

Catch yer tommorow, had one of my 24 hours sleeps last night, yep it was coming. Goodnight
crumbs
Posts: 13,757
Opinion:No Opinion
Price:6.40
So
Today 18:07
Really ... looking at Checkpoint Inhibitors... the reason they are so valuable is they came along and added a treatment that is now effective in 20-30% of patients out of 100% of patients who simply had run out of treatment options and would normally have just been running down the clock... but that still means there are a majority of patients who do not benefit and their are many cancers that they do not work on ... yet they will have a market share of $50 billion in a few years... not one company owning the patents around the tech.... My point here is that the potential value that a proven treatment like or indeed being moditope would have
crumbs
Posts: 13,757
Opinion:No Opinion
Price:6.40
RE: Ruckrover
Today 17:54
Ahh well yes of course plus... plus there are rare cancers that possibly would not be so hard to treat but because of their rarity probably do not get the research money spent on them to develop better treatments... but yes I agree not all cancers are as 'treatable' as others my point is pretty much all of them can get to a stage where there simply are no longer any treatments... I suppose then it is about numbers so no matter if one cancer is very treatable at many stages if a large number of people still die of that disease it means there is still a big unmet need/market... The great thing is moditope as a platform could possibly be effective in them all...
CHELSEA7
Posts: 36,290
Premium Chat Member
Opinion:No Opinion
Price:6.40
RE: Islay
Today 17:53
Wild, working hard is probably something most of us do, being able to get away and playing hard is more tricky.

Well done, I qalways remember at school writing about our summer holidays, I was lucky much to write of, your kids must be writing a book!!!

Hope to see you at AGM buddy, enjoy
crumbs
Posts: 13,757
Opinion:No Opinion
Price:6.40
RE: Ruckrover
Today 17:47
Just for fun replace 'the Company's dominant patent position in relation to post-translational modifications of cellular proteins and their application in the treatment of cancer.''

With 'dominant position in relation to Checkpoint Inhibition in their application in the treatment of cancer'

Now go work out a value for that.... Checkpoint Inhibitor market predicted to hit over $50 billion by 2025 (wow)

'. According to the report, the global immune checkpoint inhibitors market was valued at $10.56 billion in 2017 and is projected to reach $56.53 billion by 2025, registering a CAGR of 20.1% from 2018 to 2025.'
https://www.prnewswire.com/news-releases/immune-checkpoint-inhibitors-market-to-reach-56-53-bn-by-2025-allied-market-research-876099581.html

The moditope mechanism could prove to be far more effective far cheaper far easier to administer and be suitable to far more patients in far more cancer targets than Checkpoint Inhibitors...... yup... lets wait till 2021 :)
RuckRover
Posts: 2,140
Opinion:No Opinion
Price:6.40
RE: Ruckrover
Today 17:44
Crumbs,

The debate is whether there are in fact "hard to treat" cancers as I stated originally or whether they are all the same as Inanaco has tried to argue all afternoon.

Note the term "hard to treat" in the following: Perhaps someone could point out to Inanaco that the whole scientific community disagrees with him as do most of the more knowledgeable posters.

14th December 2017 CRUK Collaboration
“This collaboration will ensure that this innovative vaccine reaches patients sooner and could bring about urgently needed improvements for some cancers which can be hard to treat, including lung cancer – a disease where survival rates remain stubbornly low.”

31st January 2019 Interim Results

"Patents awarded with respect to the Moditope® platform and our on-going collaborations mean that we are now well positioned to develop Moditope® based therapeutics, such as vaccines and adoptive T-cell therapies, with the potential to address the unmet need across a broad range of hard to treat cancers."
crumbs
Posts: 13,757
Opinion:No Opinion
Price:6.40
RE: Ruckrover
Today 17:36
Hence the development of modi2 and indeed modi3 which we think was to be a combination of both though don't think we ever got clear info on that... what we do know is that there are potentially many more modi's in the pipeline...

'Modi-2 is currently in pre-clinical development and work is underway to characterise specific homocitrullinated peptides for clinical development that have the potential to address different cancer indications to Modi-1, including tumours with a particularly immunosuppressive environment. The Modi-2 peptide family is the subject of new intellectual property applications with a view to extend the Company's dominant patent position in relation to post-translational modifications of cellular proteins and their application in the treatment of cancer.'
RuckRover
Posts: 2,140
Opinion:No Opinion
Price:6.40
RE: Ruckrover
Today 17:31
"you can twist your posts to suit but you cannot change fact "

So says the master of post twisting!
RuckRover
Posts: 2,140
Opinion:No Opinion
Price:6.40
RE: Ruckrover
Today 17:30
For the record...

I think we all agree, cancers caught early are easier to treat, Late stage is harder to treat.

However, melanoma is more receptive to immunotheraphy than pancreatic cancer.

The word is immunogenic. hanks Bermuda on ADVFN for putting us all straight.
Wildforce
Posts: 10,229
Opinion:Strong Buy
Price:6.40
Islay
Today 15:53
Hitting the road early doors on Thursday .. really looking forward to it .. Chelsea - yes I’ve had a very good year on the holiday front so far .. I’m very lucky .. Work hard, Play hard eh !! I’m a believer in taking your opportunities in life .. following scancell is more like a hobby with a potential return included .. i find the whole sector very interesting indeed !

As ever, take care ..
inanaco
Posts: 29,521
Opinion:No Opinion
Price:6.25
Ruckrover
Today 15:34
For the record

Wildforce an Inanaco agree

Crumbs posted

I think Inanaco is meaning all late-stage cancers are hard to treat

spot on ...

you refer to pancreatic as more hard to treat that melanoma

all i explained was that is because of """Staging"""

you can twist your posts to suit but you cannot change fact
inanaco
Posts: 29,521
Opinion:No Opinion
Price:6.25
RE: Ruck
Today 15:25
no he didn't
RayPointer
Posts: 1,216
Opinion:No Opinion
Price:6.25
RE: Afternoon all ..
Today 15:25
Thanks Wild
A good post from a man in a camper van!
CHELSEA7
Posts: 36,290
Premium Chat Member
Opinion:Strong Buy
Price:6.25
RE: Afternoon all ..
Today 15:23
Afternoon guys, excellent post Wild. The serial killers along with how many trials just happen to be in melanoma and lung cancer have made a disproportionate slant to the figures we see.

That is why diagnostics and matching individual cancers to a particular treatment are so important now, and even at ASCO that message was being echoed.

Wild, have a good trip to Islay, boy you are going for it this summer?




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