Glymab from Marcus on other board20 May 2022 08:32
marcusl2: Scancell has developed a novel technology platform for producing mAbs that recognise glycans with high specificity and affinity. In the past this has been challenging as anti-glycan antibodies tend to have low affinity for their targets. However, Scancell is one of the few groups in the world to overcome this limitation and is now able to produce high-affinity anti-glycan mAbs with direct killing properties. Scancell has created a portfolio of anti-glycan mAbs that recognise and directly kill cancer cells without the need for involvement of the complement system or immune accessory cells. These mAbs also have the potential to be used for drug delivery (for example, as antibody drug conjugates: ADC), as chimeric antigen receptor (CAR) T cells or for redirected T cell killing. The GlyMab™ platform has the potential to generate many more mAbs against a wide range of tumour-associated glycoproteins and glycolipids. In a further refinement, Scancell has identified specific and precise antibody modifications that enhance the avidity of target recognition. This AvidiMab® technology has been used to increase the direct killing ability of Scancell’s own anti-glycan mAb portfolio but also has the potential to enhance the efficacy of other mAbs or antibody-based therapies currently in development or available commercially. AvidiMab could be used to enhance the avidity and potency of virtually any antibody-based product. It would also extend the patent life of commercially established programmes. Hence its appeal could be significant. HTTPS://www.scancell.co.uk/antibodies SC129: specific for the sialyl-di-Lewisa glycan, a target for pancreatic cancer SC134: specific for fucosyl GM1, a target for small cell lung cancer SC88: specific for the Lewisacx glycan, a target for colorectal cancer SC27: specific for the Lewisy glycan, a target for gastric cancer SC2811: specific for SSEA4 on human and mouse T cells with stem-like properties – a target for any solid tumour HTTPS://www.scancell.co.uk/anti-glycan-mab
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