Member Info for violindog

Douve...perhaps after we get the ModiFY update?

Konar, you could very well be correct. I think Scancell were caught out last time.

Found this on the Farn site interesting. It's related to their trial but of interest re Scancell??

The inclusion of irORR seems logical as these newer immunotherapy treatments can have slightly different observable results compared to more standard treatments .
From searching internet - this new method allows for differing time scales on efficacy ( ie small immediate improvement - but leads to bigger long term one ( ie extended life) , and in some cases the tumour size may even increase before reducing .
So looks like FDA have allowed them to adopt the more modern response measurement techniques.

To evaluate antitumor responses to chemotherapeutic agents, investigators would typically rely upon Response Evaluation Criteria in Solid Tumors (RECIST) or modified WHO criteria, which do not comprehensively capture responses with immunotherapeutic agents. In the December 1, 2009, issue of Clinical Cancer Research, Wolchok and colleagues reported their development of novel criteria, designated “Immune-related Response Criteria” (irRC), designed to better capture the response patterns observed with immunotherapies. Broad use of the irRC since then has allowed for a more comprehensive evaluation of immunotherapies in clinical trials, indicating that their concepts can be used in conjunction with either RECIST or WHO, and has shown irRC to be a powerful tool for improved clinical investigation.

JohnnyB1....many many thanks for sharing his timeline.
Not long to wait then as Scancell must surely update by official RNS... say by mid Jan. It may be sooner depending on pt x posts and if Scancell are "forced " to make an interim statement.

Scouse, analysis of scans by a Consultant Oncologist or Consultant Radiologist are almost instant. The body image appears on the screen in real time and the above could instantly interpret the results. Scans are stored electronically in a patients record and any medical professional in the network can access the scan.
Even the experienced radiology staff who do CT / PET scans day in , day out could easily interperate the results instantly. Even though many staff can interpret scans with 100% accuracy, patients are never given results until an official report by a Consultant Radiologist is made in the medical notes.
Blood work...totally depends on what is being looked for.

She has posted again 50 odd mins ago..and states about the next scan results :

"I'll let you know "

For those that don't know...the results are instant. As the body travels through the machine an internal body image is revealed in real time to the clinical staff observing the screen. In normal practice although even junior radiologists and medics can easily interpret the results its not good pratice to inform the patient immediately. The images are then sent to a Consultant radiologist and a report is then sent to the clinical team. Only then would a patient be informed of the result. In this instance I would expect the above scenario to happen almost instantly...perhaps even Christian Ottenmeiner will be present observing the scan.
Question is... has our patient on the Macmillian forum now been told / asked by Scancell not to share any result on the forum prior to any official RNS by Scancell . I would love to read a about a wonderful result posted on the 30th or shortly afterwards ... but I will not be concerned or take it as a negative if nothing is posted. Of course, there are ways of conveying a message without being direct : ))

Re Covidity...in my opinion initial reaction will all depend upon how Scancell write up the RNS . Guess most retail investors will only be looking for the words ..commercial etc. Pharma will be looking at the "detail" re Avidimab , pharmajet delivery etc etc. So we may get a muted response from retail but a different opinion from pharma, both affecting the SP and perception of Sclp in different ways . Of course Covidity results may be brilliant.

Chelsea7, indeed brilliant feedback from AGM .
Off topic ..did you ever receive the email I sent you ..ages ago now .

Miavoce...so funny...just what I needed today..thanks x

Hi C7, i wonder what the feedback will bring from the investors who attended?
Very positive about the expanded sites as detailed today..I take this as a good indication all is well with the Modi1 trial.
On balance, having looked at the history of the patient blog I'm convinced she is genuine.
Funny how Covidity has taken a back seat with all the excitement around Modi1.
Take care all x

Chester, agree, SCLP could occasionally throw us a bone !!

Such a shame we just can't seam to hang onto any SP gains , steady drift down ...again. Fundamentals jusy get stronger and stronger with each Rns .. we should be going up.. not down . At the very end of the trading day look for those regular tiny sales ensuring the final price is held down.
One thing is for certain.. trial results will speak for themselves and if what we believe from the Macmillian forum... these will be amazing. Guess we just need to accept that we will drift down between each RNS until finally SCLP is taken over for a decent price.

Wild, that's fairly typical of the NHS l am afraid to say. From my experience it is the Research Nurses who really run the trials . They are the ones who get trained, do the leg work and find suitable patients to put forward for the Consultant to "sign off" . You obviously need the consultant to agree to the treatment but so many are still stuck in the past and not open to new ideas or treatment options.

"Profits drop at BioNTech as Covid vaccine demand wanes"
Article in the Financial Times... but behind a pay wall .
BioNTech could certainly boost future revenue by taking a bite out of Scancell ...or go for the whole meal ticket : )))
Hopefully we will soon get a bidding war as Scancell power ahead in the lucrative field of immunotherapy... just at the right time when some of the major pharmas either need to boost revenue or are looking at patents expiring.

Trish also said that she was feeling well and her swallowing was much improved.... from memory and not a direct quote. The thing is... hopefully the other 2 pts are also having symptom relief. They themselves, their families and perhaps even team Scancell will know Modi is working even before its confirmed by a scan, obviously it depends upon tumour shrinkage...hopefully they too will be in the 30% range. How wonderful for them if this happens.

On balance, I think the Macmillian post was genuine, so next scan Nov 30th .

AB, yes I'm am an "investor" but like many LTH s in Scancell I have personal reasons for investing to try and find a cure for cancer. I have participated in every single fundraising to keep the lights on way before Redmile even heard about Scancell. To think a drug that I helped in my own small way has the potential to cure patients with terminal cancer.....yes.. that does make me gleeful . I have waited many years to read a post like the one on the Macmillian forum and lost friends and family to cancer along the way . Sometimes it isn't about the investment...but without the capital LTHs provided would that post have been written.

........
Tilly posted again on the same link ...

I'm in cohort 2 so im having the increased dose with an added peptide.

They are recruiting for cohort 3 now and they will be having the same as me but also with Pembrolizumab.

Scancell are very confident about this trial, if positive results continue at the rate they have done so far imagine what this means for patients in the future.

Trish

Wild,
Scancells RNS " headline " certainly didn't reveal the gem that was contained in the body of the RNS . It is simply amazing news that could have been in the RNS headline. Guess Scancell are just getting on with the trial (s) and reporting to Redmile and Vulps ...at this stage the only investors who really matter. That said, it looks like Vulps shares are being mopped up anyway.
Will we get any interviews prior to the AGM or a mega blitz afterwards.
Amazing how quickly this year has passed already.
Feeling very pleased for all LTH s ...my extended on line "friends" ... certainly been through some ups and downs... and the occasional fund raise : ))