Member Info for Ivyspivey

Thanks Wilson,
Remember reading the original research notes from Myles.Did I read somewhere that he was hoping to update today.

B2H2SL
The type of virus is not a huge issue once you have the genomic sequence and can isolate those specific antigenic responses.
So the fact that affirmers are clinically robust and the fact that a major pharma player has validated the AVCT approach are of big significance imo

Sensitivity is the percentage of persons with the disease who are correctly identified by the test. Specificity is the percentage of persons without the disease who are correctly excluded by the test. Clinically, these concepts are important for confirming or excluding disease during screening.
So if a test is only 90% accurate and you are doing 100,000 tests per day the govt end of April daily target then on average 10000 people will be false positive and another 10000 false negative so you can see how the numbers can easily ramp up.
Given the fact someone tests negative( including the false one in ten) they are likely to behave in a less strict fashion/ not to be in self isolation hence likely to infect more people).Also the false positive one will be investigated ie contact traced with effort.
Also by giving an individual more tests yes you will reduce the chance of it been wrong but how often do you repeat the test and why would you repeat it unless something changed like symptoms etc and of course you do not know which individual s are tested correctly or not.
Plus what if the efficacy is only 80% riptide gets exponential.
My experience is only using a rapid point of care tests in cats assessing FeLV and FIV both deadly virus,s.That was a whole blood test which was 97/98% accurate so pretty decent.
We still had false negatives and positives but on the whole worked well.The consequences of a false diagnosis are huge in terms of outcomes so to keep these to a minimum is a major factor.
ATB

PS
Inniovo using different device

Device: CELLECTRA® 2000
EP using the CELLECTRA® 2000 device will be administered following ID delivery of INO-4800 on Day 0 and Week 4.

https://www.who.int/blueprint/priority-diseases/key-action/Novel_Coronavirus_Landscape_nCoV_11April2020.PDF?ua=1

FYI is current list of Covid 19 and a couple intend to use Electroporation and a mention of Karolinska Institute

Simplest way to explain it is to ask is it safer to have 10 people who think they maybe over the alcohol limit but have not been tested so don’t drive or 9 people who have taken a home 90% accurate test and passed and all decide to drive.
So at best no one who could be over drives and at worst 9 drive who are probably under the limit but 1 who could be way over the limit decides to drive as he has passed an inaccurate test.

Faze 1 absolutely correct BUT only with an accurate test.
If specificity and sensitivity parameters are not good enough so you have false positives and false negatives then that is much worse than no testing.

Morning
Vegas when you say competitor do not focus on how quick it is but how rapid and accurate as without figures on specificity and sensitivity it is pointless trying to compare tests as if they are not accurate they are useless.
All Companys making tests will use this Covid 19 opportunity to raise money or sell tests but if no accuracy figures are available then you need to base decisions on approvals by official body’s or track record or validation of big pharma like here

The lab and diagnostics operational side of AVCT is run separately as it is Animal Health based in Wetherby.Traditionally this has been loss making However the use of affirmers in Human diagnostic technologies will now be a core part of the business.

This is specific but.

The Group intends to commercialise Affimer based rapid diagnostics through co-development and licensing to third party diagnostics developers an example of which is Mologic, a UK rapid diagnostics developer, with whom a research and product development collaboration was recently announced.

Mologic Partnership
This goes back to 2016 with use if affirmers in Zika virus work

https://www.lse.co.uk/rns/AVCT/affimer-binders-for-zika-virus-diagnostics-ny1nvoqnoculwlu.html

Roxbury House,
I think the issue is the 100 or so reported cases from South Korea and others where people who have been infected have thought to be reinfected.
Assuming these are correct you need to work out have they been reinfected from community transmission or has the virus acted like Herpes Zoster and be one dormant and reactivated.
If it is proven that immunity is short lived or non existent then yes the whole question of a Vaccine and AB testing becomes much more challenging.However in that situation and that would have disastrous implications for us all a raid point of care test would be one of the most critical elements of contact and trace

No worries Gold Girl and best wishes here.
Like others I had been in from the start in 2015 and after attending last years AGM and speaking to GL it became clear the DILI issue would not be easily overcome hence I sold the rest at a big loss and just moved on.
I always said I would only come back in on news and apart from a very small trade on Friday due to simply a couple of people taking a position who I knew would attract others and at such a small market cap the short term risk/ reward was decent I will await news.
The placing at 0.42 and the fact most of the asssets like Iclaprim transferred to Hercules means they will be the initial beneficiary unless any deal is greater than the amount owed.
Plus any deal would have to be enough to pay or 2 new phase 3 trials so another £30-40m or so and given GL had contacts with most of the likely bidders I just thought a deal would have been done by now.
If a deal comes this will be worth much much more and GL to all

Not a flipper,
Your research seems really comprehensive and thanks for that.
One pint I think you said Alderley Park was near Sheffield.It is actually in Cheshire near Alderley Edge about 8 miles south of Manchester.
It is the former site of Astra Zeneca for many years before they moved to Cambridge.
ATB

Morning,
Couple of observation.
Prof Sarah Gilbert of Oxford Uni probably one of the leading developers of a Covid 19 Vax reckons there will be an 80% chance of success by Sept.So human testing kindly to start in May to test safety and have results by Sept.You then test efficacy and at same time scale up Vax production.
Vax productions takes months and you cannot just switch current facilities so have to build new ones so likelihood of having a Vax available at earliest will be next April.
The reason why you do not get a HIV Vax as it is so virulent you need to use a killed Vax which means a adjuvant etc.
We don’t know enough about Covid 19 yet and as a RNA virus it could well mutate.
So we need to find the right vector etc.
Therefore you need a lot of testing and a rapid point of care PCR test is a game changer.Yes any test has to be accurate which means high specificity and sensitivity.
ATB

You have to be a little careful and make a distinction between a rapid test that needs a lab and a rapid point of care test.
I have certainly been involved in selling rapid point of care tests in the veterinary industry testing for virus’s and am well aware of the differences and benefits of a point of care test as compared with one that needs to go to a lab in terms of cost and time saving

Mad punter,
Post recommended as gave me a laugh.
The funnier thing is I probably know about 50 vets in North Wales ( my day job) including several from Wrexham and I dare not tell them that take as if is too close to the truth lol

Morning Mike,
If anything a relaxation in lockdown terms will mean an even higher testing requirement particularly amongst the community.
A rapid point of care test which does not require a lab setting will be hugely beneficial in monitoring any so read of Covid 19 and in contact tracing.

A reminder that AVCT are one of partners in using affirmers.

https://mologic.co.uk/mologic-and-partners-begin-validation-process-for-covid-19-point-of-need-diagnostic-test/

Always remember those days when you were trading GLEN and that has been my approach in recent weeks and yes I will invest in the bios like here as that is the bit I understand but certainly will not risk big amounts however strong the case looks or at least not hold based on one specific catalyst.
Am lucky to be working from home and such a supportive employer so all good from me.
Hope Mrs Sheltie has forgiven you and all are safe and well.
It was such a lovely feeling in Wednesday morning on the RNS but of course we have to go through the drops as well as the rises on this rollercoaster ride.