RE: What data will be given for science day?12 Feb 2023 14:31
JT
Good explanation including point that AVA6000 keeps circulating past the TME and hence cleaving more Dox leading to 18x (or whatever) in tumour versus blood/heart.
But, as I keep asking, what if the metabolism of humans is such that the AVA6000 is excreted from the body much faster in humans? Then the TME would not be getting the same exposure to AVA6000 (and therefore Dox). Therefore we might have to go to higher dose levels to get the desired efficacy. And hence prolonging P1a.
As I said before, I don’t necessarily see this as a bad thing. And it would explain what is happening at the moment.
Abuse incoming I guess.