Member Info for Toukankahmoon

Al isn’t going to go with the highest price you numpties.

Al will go with the deal that is best to nurture his brainchild into the future. Simples

CTSFO

Thank you. I am not in any way saying AVA6000 won’t be successful. I’m just trying to understand the complexity of efficacy on different patients and the potential effects of concentration of AVA6000 in the bloodstream, rate of excretion, exposure at the tumour site and rate of cleavage of dox.

Thank you

CTSFO

You obviously know more about this than me. But if the level of AVA6000 in the blood drops quickly (by excretion or flushing or whatever) and cleaving dox to the tumour is slow for whatever reason it seems obvious that less dox is going to get to the tumour for a given dose of AVA6000 and therefore results will not be as good.

Of course the reverse is true perhaps for the patient with a significant tumour reduction.

For those keener to shout me down rather than trying to understand what I’m saying;

If what I am thinking is true it would also explain why Avacta are so coy about releasing detailed results so far and would prefer to wait for emerging results from fortnightly dosing regime.

CTSFO

The point I’m trying to make against the barrage of . . .

Is that AVA6000 is flushed/excreted (whatever you want to call it ) from the body at a rate which will be different for different people. The rate of cleaving will depend on certain factors different for different people.

If cleaving and therefore dox delivery is slower and AVA6000 excretion is faster this will result in less dox in the tumour and so less efficacy. The contrary will be true leading to exceptionally good results.

Fortnightly dosing ensures a higher amount of AVA6000 circulating in the blood for longer. So this trial is very important and should result in excellent results even where delivery of dox at the tumour site is lower than expected.

I have a theory with the fortnightly dosing. It has been mentioned by others

We know that safety has been satisfied. We know that levels of dox are being cleaved to the tumour area and that little is escaping into the bloodstream to damage other organs. We know that in a few cases the dox levels are high enough to achieve spectacular results but we don’t have the actual clinical trial figures for the other patients to see what has happened in their cases.

Uncleaved AVA6000 gets excreted from the body. I imagine this depends on many factors: characteristics of the tumour itself, volume of blood supply to the tumour, patient’s health, metabolism etc. Just suppose the AVA6000 in some cases is being flushed from the body thus diluting the dosage level in the blood, too quickly to be cleaved by the FAP as quickly as is desired? It would make sense to try dosing fortnightly thus keeping AVA6000 levels in blood higher for longer and achieving better results. Also this information would be a must in order to inform P2 dosing regime. And of course the safety of AVA6000 allows this more frequent dosing.

Just a thought.

It is the delusional rampers that are bemoaning the SP and promising pivotal RNSs any moment now. The more rational are just trying to explain why we are where we are and that nothing is likely to change until P1 finishes around mid year hopefully.

Apre

“Derek,

I can't imagine you ever had a batman.

Battboys though? Yeah . . . Can you remember your first one of those?”

How you can claim this isn’t abusive I really don’t know. You must have a sad life to get off on abusing strangers on a bulletin board.

Is that like 5 o’clock shadow?

Mind you most blokes sport beards these days.

But for the record I agree with icecool summary of where we are. And for me the upside is far greater than the downside but nothing of financial significance is going to happen until the fortnightly data is analysed and published. There are no clandestine negotiations going on behind the scenes that will be announced in an RNS next week or next month. There will be talks going on I’m sure but investors need to see the actual figures from end of P1. Not weasel words about “encouraging “ or “promising “ etc.

So we wait

The future is bright for us and also cancer sufferers

Apre posted

“

I occurred to me that perhaps 5 o'clock is the start of 'free association' time on their ward\cell block. They pretend to be doing research for their GCE's on t'internet but just have a whinge fest while trading snout and chocolate . . . phew, kids eh?”

But doesn’t think it’s abusive!!!!

Watching

I said that I hoped Icecool is right. What do you want me to add?

As to the boring jibe about working for TW, who are you being paid by?

Apre

Have noticed how it is mainly the paid rampers are abusive? Grow up

Ice

I really hope you are right

BTW

What outcome did you want from sending Svacta a message?

Flippin

Where did I say that?

Just commenting on what seems an act of spite

The LFT debacle and communications and expectations set then and since are very relevant because an important measure in assessing an investment is the quality of the BoD.

Flippin

So if you’re not invited get the meeting stopped so no one gets to find out news and pass it on to us.

Well done!

End of P1 data will be enough to derisk it for BP regarding the platform and decent licensing deal for AVA3996 will sort out financials.