Member Info for sadoldgit

MyIPA.
Just checked P2F website, what is your take on this?

https://www.pharm2farm.org/face-masks/

My IPA , intersting the wearing of masks. one of the most important aspects of mask wearing is a face seal. Have you noticed on a cold day those that wear a material mask pulled tightly over the face and wear glasses that the glasses get steamed up?

There is a gap either side of the nose. Whilst this mask will reduce the amount of exhaled or coughed air into the environment it is by no means anywhere near 100 effective, furthermore in this application it is used to afford some protection to others but very little protection to the wearer. The P2F mask has a great fit around the nose area ensuring an effective seal. It is postulated that to become infected around 1000 virions uptake is required and further studies are in progress.
Dilution in the atmosphere of the virus is important with regards to containing the spread of the virus. Any vital organisations like the NHS for example would not only benefit immensely from these masks but also the nano technology, potentially being used in Air conditioning systems. Most systems use recirculated air.
One of the biggest transmitters of viruses is passenger aircraft especially long haul flights. No reason why nanotech particles cannot be used and in this application dependant on filter size should/would last a hell of a lot longer than a minimum of 7 hrs.

Regards

Coronavirus will last longer in air humidity levels of less than 50% When moisture evaporates it takes the virus with it still in tact. The corona virus prefers room temperature and just under 50% humidity.

On many surfaces, including as glass, some types of plastic, stainless steel, and skin, the virus can remain infective for several days indoors at room temperature, or even about a week under ideal conditions.[182] On some surfaces, including cotton fabric and copper, the virus usually dies after a few hours.[182] As a rule of thumb, the virus dies faster on porous surfaces than on non-porous surfaces.[182] However, this rule is not absolute, and of the many surfaces tested, two with the longest survival times are N95 respirator masks and surgical masks, both of which are considered porous surfaces.[182]

Very true MyIPA corona virus typically 50 by 110 nanocron. All a virus is, is nucleic acid surrounded by a protein. You seem a lot more knowledgeable than most on this board lad.

https://www.youtube.com/watch?v=JiKh8sdVNTs

I can find no elevated levels of IL-1 with respect to Covid 19 in Wikipedia

I will add. I think the ball is in the back of the net!

GM-CSF covered by TYK 2 and Jak 1 indirectly.
All cute and of course no toxicity from a JAK 2 but much more selective with TYK 2 and the magic dash
of JAK 1
Regards

Hi Ahfam from October 2010, Just a reminder

There is substantial evidence in the scientific literature to suggest that inhibitors of TYK2/JAK1 signalling could address the severe inflammatory responses (the "cytokine storm") and potentially fatal respiratory symptoms of Covid-19 and other viral infections.

Several clinical trials with JAK kinase inhibitors have been started to investigate the potential of targeting this pathway as a therapeutic approach. On 8 October 2020, Eli Lilly & Co. reported promising data from its Phase 3 trials of baricitinib, which inhibits JAK1/JAK2 kinase-mediated cytokine release, in hospitalised Covid-19 patients. The data showed that baricitinib in combination with the anti-viral drug remdesivir significantly reduced the time to recovery vs remdesivir alone, particularly in patients that required supplemental oxygen. Mortality was also decreased, again more pronounced in patients receiving oxygen.

Sareum has applied for grant funding to conduct preliminary laboratory studies investigating the ability of its TYK2/JAK1 inhibitors to modulate (down-regulate) the overactive immune system in relevant cellular and mouse disease models.

From recent Patent description

The non-receptor tyrosine kinase TYK2 plays essential roles in both innate and adaptive immunity. A lack of TYK2 expression manifests in the attenuated signalling of multiple proinflammatory cytokines and a profound imbalance in T helper cell differentiation. Furthermore, evidence from genetic association studies supports that TYK2 is a shared autoimmune disease susceptibility gene. Taken together, these reasons suggest TYK2 as a target for the treatment of inflammatory and auto-immune diseases.

Several JAK family inhibitors have been reported in the literature which may be useful in the medical field ( Ghoreschi et al, 2009. Immunol Rev, 228:273-287 ). It is expected that a selective TYK2 inhibitor that inhibits TYK2 with greater potency than JAK2 may have advantageous therapeutic properties, because inhibition of JAK2 can cause anemia ( Ghoreschi et al, 2009. Nature Immunol. 4, 356-360 ).

Even though TYK2 inhibitors are known in the art there is a need for providing additional TYK2 inhibitors having at least partially more effective pharmaceutically relevant properties, like activity, selectivity especially over JAK2 kinase, and ADMET properties. Thus, an object of the present invention is to provide a new class of compounds as TYK2 inhibitors which preferably show selectivity over JAK2 and may be effective in the treatment or prophylaxis of disorders associated with TYK2.
Covid 19 causes of cytokine storm ( source wikipedia)
IL-1, IL-2, IL-6, Interferon gamma and TNF alpha.
IL-2, IL-6 covered by Tyk 2 , TNA alpha along with IL-10 and type 2 interferon ( of which there is only one interferon gamma covered by JAK1.
Not sure about IL-1. Tired and sleep time. But the above looks extremely promising so far amd GS-CSF controlled by

Boris really has no option but to pursue this route.
Latest Covid news below is a link
https://www.thesun.co.uk/news/14906898/new-indian-variant-four-in-ten-london-cases-covid/
Regards

HBD. I seem to recall that event. Twas several years ago now. Yes it does exist in soil as does tetanus which can prove to be fatal too. The way Anthrax gets into our system I believe is via ingestion and especially inhalation. Many years ago infected sheep were burned. Burying them alone proved to be no good. I seem to recall a dead sheep that had been buried 50 years previously still contained Anthrax in the decayed matter in the soil.
Dear old MOD and various other military establishments around the world developed it to a weapons grade. Some have been destroyed but some still stored in sealed vaults.

Morning HBD. persons will have an entry and exit price to take a profit. There will be some that sell a few and keep a few. I not like big fluctuations much rather see a few percent a week. Traders will come and go which will cause spikes and falls.
My take for what it is worth is generally a steady increase up ( shares don't go up in a straight line) until June when we will get to hear of progress with CTA application. If all goes well, yes will go bananas.

The price after CTA granted and success in any way shape or form as an effective Covid treatment is anyone's guess. Don't pay much attention to the SP but the Market Cap.

How much would TYk 2 be worth if found suitable for Covid 19 alone?
Without the Covid angle just the cliinical trial in humans will put the market cap at an absolute minimum of 250 million with potential it has for its intended targets it was originally designed for. This is in my opinion only, just pure speculation nothing else.
With effective Covid19 results after trials, I billion upwards to blowing the doors off into outer orbit, again just my opinion and speculation.
It could of course all go tits up and be found fit for nothing ( worst case scenario). The likely hood of that diminishes each day and is looking very very favourable for a successful outcome, Again my opinion and hence speculation.

Not much else to add. Is 3 billion possible? Not impossible so therefore possible. next we look at probabilty. Based on what other compounds have been sold and bought for with milestone payments has run into the billions. So yes probable.

At the moment and if all went swimmingly well how much would a pharma be prepared to pay for a compound that is effective in treatment for Covid and potentially all other immuno diseases we know about ?
Recent patents
Low toxicity
Great ADME
The only TYK2 Jak1 compounds commercially available.
Made in the UK

Billions with milestone payments. But hurdles need to be crossed.

In answer to your question it will not spike to a pound without news or a corresponding RNS to substantiate such a rise. We may reach circa 5p territory within a month. I don;t know Should an RNS announce a deal for licensing or collaboration the price will go up accordingly to projected worth. We just do not know what the future has in store.

Regards and see you in the £1 club haha
I

Absolutely, that is the one jobjobbed. Will all go quiet now as Biden that far up the Chinese backsides.

Whatever the cause the Covid will be around for a while yet.
Fortunately little Sareums Tyk 2 compound not only showing promising results in their intended targets (albeit in models) also shows great potential with respect to effective treatment of covid19 and its associated effects. If this were not the case then they would not be eligible for the Agile source of funding and CTA application. It would have been looked at with a fine toothed comb.

Correct me if I am wrong, but what other option do the government have ? There is still no significant, effective form of treatment available with our NHS doing the best they can with what they have at present. Oxygen and ventilators are all there is at the moment, but this is far from a cure.

I am also of that opinion myself ie weaponised virus.
Most bacterial diseases can be treated with exceptions, Anthrax to name but one and this still exists in storage. There is no cure for Anthrax and its spores can last for 50 years underground on a dead animal. Banned and absolutely illegal to keep with the exception of Military establishments. There exists weapons grade Anthrax!

Viruses as you know are difficult not only to detect but have the ability to spread and mutate. You are not nuts at all Thoth.
Cross mutations of viruses have been worked on for years in research labs, and is extremely difficult to achieve, as in the strive for survival one particular strain will prove dominant over the other.

It is not something achievable overnight. Alas in our lifetimes I doubt we will ever get to know the true origin.

The effects of the Covid 19 so far have taken a very heavy toll on peoples health physically and mentally, plus the financial consequences too, costs have been horrendous. The only benefitting economy as far as I can see is China. Is there declared figure of circa 90,000 cases of Covid 19 since the outbreak began in a population well over a billion people believable?

Regards

I don't know about you Stoney40, but I do feel very confident about the Tky2 compounds, expect a gradual tick up here over next couple of weeks.
Tim was confident a year ago. Looking in depth at the Patent description in my view we are already there with regards to CTA. But of course we have no option but to wait for the results of the trial.
Regards

Utah, What is your problem with Covid 'stories' I put one post up about a mutation that had been posted on another bb for comment? So it is not 'stories' but story . If you do not want to read that is your perogative but there others that may want to read.
I am not overly concerned of your tale if you are an industry essential worker and had your injections or not.
Regards

Good morning Stoney, Seychelles have carried out one of the largest vaccination programmes but are now in a lockdown due to an increase in Covid 19 detections.
Lockdown not been easy but I do feel once travel is resumed then shortly after we will see a dramatic increase in cases. Having Covid 19 or vaccination is no guarantee that you will not catch again.
I can understand governments being pressured by organisations to get travel up again but unfortunately this will come at a cost I feel. Certainly not the time to lower ones guard as Mafuta has already said.

Thanks for that Matt, I tried looking for further info but unsuccessful.
Regards
Stories haha

Any views about this. Not sure if genuine or not.

'This was posted on the avct board interesting and concerning
RE: Worrying new variantToday 16:46
Received this today from friends in China. It appears to expand on credible reports if you search "chongqing" in news search engines.

According to news reports, today there are three Chinese working in India, After returning home from India via Nepal, the initial tests were negative when they arrived in Chongqing, but the doctor still had doubts, so he gave them a CT scan. They were found to have lesions in their lungs and confirmed to be a triple variant of the Indian virus, proving that this Indian super variant can evade current testing, However, most of the checkpoints are only conducted by ordinary tests. Hong Kong and most other countries do not require immigrants to undergo CT scans and do not have sufficient time and resources to do so. If the estimate is correct, we believe that the fifth wave of super virus outbreak will soon appear in Hong Kong and the world:
Message from Singapore:
* virus is back *.
This time there is more energy,
Tactics and camouflage.
The infected person does not cough and has no fever.
* This time the symptoms are joint pain, weakness and loss of appetite. *
Death rates are higher and the time to reach critical is shorter.
Sometimes without symptoms. ..
Be careful. ..!
This strain does not reside in our nasopharyngeal region!
So no more prodromal symptoms such as loss of smell or taste, it attacks the lungs directly, shortening the onset time.
Many patients who do not have a fever,
But X-rays showed moderate chest pneumonia!
Nasal mucosa sieve test often shows COVID19 negative!
More and more false throat and nasal findings.
(COVID19) This means that the virus spreads directly to the lungs, causing acute respiratory distress (hypoxia) from viral pneumonia!
This explains why it became acute and so much more deadly!

I hope it aint true!