Member Info for sadoldgit

Basser you write some tripe. Who is everyone and what do they need to know? Come on Basser elucidate a little more. If you are offended feel free to block me I really do not care, or anyone else that chooses too. We all have different opinions and views. Wouldn't it be boring if we all thought the same.

What is it that they need to know?

Fearg, That is my opinion of Biden of which we are all entitled to our opinion. Yet you have imbeciles on here who will quote agesim yet I have old in my name. Yo need to get a life Del boy you silly little snowflake
Posters on here can complain knock Donald trump and know one says anything.
How very 1984!

My comments are my comments and opinions.
And Basser Trump was a good president removed by the tactics of the new world order. Postal voting? What a joke. more ballots posted than there were voters. Dead people voting.

End of will not bring up politics anymore

Enogh and subject over.
Regards

Del Boy and Rodney what post is that?

It's was only that daft senile old fool gropey Biden postulating about patent removal. It is complex. Up front payments have to be made. The law is different in different countries. Opened up a right bag of worms. I think I he needs some form of treatment for his dementia.

Many patients now being admitted under the age of 40. Especially the latest strains. Will get worse before it gets better . Idiots getting complacent too. Increasesd mental health issues as direct result of Covid

The ball clearly lies in the interested party or parties. They can make offers. Sareum can sit back and wait for result of trial. There is almost no chance of a CTA not being approved. I would think most of this has and is being resolved in the background. I dare say offers have been made
If we show positive fir XY and Z we will get this. If we can treat Covid then add another nought on the end.

Will be a nightmare for Tim working all them milestone payments out. But, better than that should it work,will be the end of so much suffering and death to the world of the old, not so old and little children That you can not put a price on!
Regards

I reckon Chinese have one already. Sinfoflitflee. Glood copy of slaluem.

Regards and good to have some humour.

Directors are not forbidden to buy shares but have to declare if buy or sell. The downside is speculation as to why they bought or sold.
Having shares can also be a cause for concern with regards to a conflict of interests. You cant win, either way someone will jump on you as to why.
The Director could own all the shares in a company.

I don't think you will have may months to wait. Pivitol point will be, grant of CTA, ( uplift 50 to 100%) trial, then further grant more up the Agile ladder another 50 to 100% then anybodies guess on licence or take over Up to 10 million grant small to medium size enterprises available on Innovate Agile plus platform grant. Perhaps Boris may buy a few hundred shares.

This share has had its ups and downs as we all know. No failure on any part or in anyway whatsoever fault of Sareum. Always been beyond Sar's control. Take for example Sierra holdups. we have very little clout and even less say. FLt3 with the Chinese I think we were well stuffed. 50k for borrowing our compound, from an undisclosed pharma that wants to keep hush, then claim cannot provide sufficient bioavailability. More than likely been copied and put into a vaccination/treatment programme. We will never get to know.

Sareum are pretty much in total control on this one. Tyk2 SDC1801 and SDC1802; Wholly owned!
The selectivity and lack of toxicity with regards to the compounds cannot be taken away. It is not a case as in other pharma's agenda of, lets see if this works and how much money we can coin out of the obsolete toxic compounds we have. It is a case that TYK 2 has been invented/designed and developed for immunotherapy and just happens that Covid 19 is just another potential target.
Regards

It is just coincidental that the correct little buttons that you have to press are extremely similar to the little buttons you have to press for Covid 19. I can envisage people saying in years to come. What came first? Tyk 2 Jak1 or Covid 19. Most will get this wrong!
No intention of ramping here. Is is all down to Sareum. They have put the dedication and attention to detail in.
Tell me please, what other options/outcomes are there.
Covid is killing thousands daily. India is in a severe state. Situation not helped by prescribing cortisones ie steroid treatments. Wipes white blood cells out and the poor buggers are loosing parts of their face to a black fungus. Something else the world can thank the Chinese for.

Yes Latino, a potential ramper or deramper that has their own agenda. No shortage of these New strain of Covid sit/work from home traders. You only have to look at the tripe they post. people wonder why the price fluctautes so much, Just need to look at themselves.

Cause of upswing, It is called market sentiment.

How does SNG interferon beta, a treatment for an impending cytokine storm? What does it do and cow does it work. Does it have the potential to treat other immuo diseases? Sorry, but I do not see the comparison.
Regards

Well done everyone for holding? Half of them on here been talking about bailing out on the next spike. Influx of traders on here cause the large spikes and falls. Those that call themselves investors.
On good news this will have big increase until then we only have speculation. dependant on how good the news is then anything from 2.5p up in my opinion.
Regards

Tim M been looking at Covid for over a year and has looked confident and excited. He would not be pursuing this if there were doubt in his mind. There are two other platforms in agile each eligible for grants depending on the outcome of the previous stage.
Not long to go now.

Charts not really of much use on this share.
Understand what is in the pipeline and the potential.
Look to see what competition we have.
Get to understand the a little more about the compounds ie JAK family. Tyk 2, Jak1, Jak2 and Jak 3
Tyk is very selective, and can select better than Jak too with less toxicity. Jak 3 has very limited selectivity but can be effective ( but not looking likely in Covid treatment) then again requires Jak 1 in tandem to allow it to work.
Jak 2 has side effects.
First generation of JAK inhibitors have had their day with most that do have a positive effect off set but their adverse side affects. Predominantly JAK 2 and Jak 3
TYK as clean as a whistle that is to why we have so little or no toxicology problems.
Tyk2 IL-2, IL-6, IL-7 plus group 1 interferons signals through STAT 5 pathway, Jak 1 IL-10 and Interferon gamma signals through STAT 3 pathway.
Nothing out there to compare or compete with 1801/1802.
What use is a chart! World will be waking up soon to it.
Regards and good luck all.

Worldgonemad
As IPA stated it clearly is an old advert. M/c could not be set suitably for 5 ply as had to have a mod. Pity the mod did not assist in the production of the 4 ply mask, but hey ho they live and learn.
Good news will arrive just a matter of when.
Regards

High Ahfam,
looking through and cross referencing ie Covid 10, Interleukins, granulyte macrophage colony stimulating factor, macrophages, CD4 positive cells T helper cells) CD4 (T killer cells) there is also a regulator cell too, and this is decided by Interferon gamma, Interferons, STAT pathways, Tyk 2 inhibitors Jak 1, 2 and 3 inhibitors and many other subjects mainly from Wikipedia which is pretty well up to date.
Tyk 2 also regulate IL-7 and IL-12 ( IL-12) will signal Interferon gamma. Tyk 2 signals via STAT 5 pathway whilst Jak1 signals via STAT 3 pathway'
All looks very very very promising. Tyk 2 has limited targets and hence can be made far more selective. JAK 3 reacts with too many Interleukins!. JAk 3 also requires Jak 1( Jak 3 requires Jak 1 to work in partnership or will not work at all)
Jak1 and Jak 3 only inhibitors will run the risk of very high risk of serious side effects ( That is why they have had NDA issued black box warnings)
JAK 2 is effective but here again reacts with too many Interferons etc, and hence has side effects due to interferon production of which we need, being halted and hence counter productive. More associated health risks with this one.
TYK2 more selective thanJAK 2 without associated side effects.

I have cross referenced with the description of our patented TYK2 and my current conclusion, so far is looking good to satisfy CTA requirements.

One thing I have concluded is
There does not exist a first generation of JAK 1, Jak 2 or JAK or any combination that will be suitable to treat immuno diseases sucessfullly due to the above lack of selectivity.
As far as I can see, and someone please correct me if I am wrong, that we have certainly no serious competition in any shape or form,with regards to not only Covid19 but also the original targets of intent.
Regards all

Thanks for the mask feedback MyIPA
Regards

MyIPA, UV has been used for ages in the sterilisation of water. Yes, no reason as to why it cannot be used in large enclosed spaces. I would hazard a guess it would take a while to install such systems and in the mean time the are would be out of service. The UV modules I reckon would need to be large too to accommodate sufficient time for virus exposure to the UV light.
Regards