Member Info for sadoldgit

Both Baricitinib and Remsdisivir are recommended not to be a single treatment for Covid 19 by WHO.

Indeed desperate measures to afford nothing but a tad of false hope, in the belief we must be seen to be doing something.

Regards

Celtic007. I firmly believe the Indian variant of Covid 19 will neither be the last or the least deadly. Not wishing to be pessimistic in any way.
Until we have an effective treatment the whole world will be at its mercy. Someone, please tell me I am talking pish.

Regards

The elderly, infirm and overweight are far more succeptible due to far from perfect immune systems. Exercise and diet play an important role. But not the whole of the story.

Viruses have the ability to mutate and do this as a method for their own survival. They will adapt to an environment, As a general rule the more transmittable a virus the less harm it does and the more fatal the virus the less transmittable it will be. With Covid 19 the general rule has been broken. The virus has evolved to survive!

Vaccinations as a prevention will help but not a be all and end all. Proper masks and the correct wearing of in many applications will help and again not a be all and end all.
An effective treatment of which there are none so far needs to be established. I believe we are on the cusp of having that very treatment in:-
1 reduction of cytokine storm
2 an effective recovery treatment for organ damage.

Regards and these are my most honest conclusions.

Good evening Ahfam. Quiet at work so more research was undertook. I compiled my findings in a post but all disappeared'

Findings are all positive for our SDC 1801 compound and it is proving more conclusive to the effectiveness of such with respects to Cytokine storm or to be precise the control of. As a treatment for long term effects indicates such promise but new data is added all the time.

I would hazard a guess ( as postulated by some on here) that indeed there is a likely hood of a specific compound for treatment of Covid 19 both in control of cytokine storm and as a recovery treatment. Sareum will keep their cards close to their chest so as to speak with regards to this. Jak 2 and 3 are just not selective enough. Jak 2 is good but not as selective as TYK2. For some time WHO have recommended a TYk2 with respects to an effective treatment!

I am unable to find any effective treatment ( unless you look at the national Institute of allergy and infectious diseases which indicates a significant success with regards to Covid 19) Most prove non conclusive when looking at the recommendations stipulated by the WHO. NIAID is a US body! I dare say a sense of favouritism reflected here.

All looking good for us, we will know soon enough. Covid 19 is not going away for a while yet!

Regards and have a good weekend

Thanks Potnak for that info. Not know how I missed that. Interestingly, will be of slightly different selectiveness, but basically both are Tyk2 Jak1. Tweaking off compounds in groups 0,1 and 2 to achieve this me thinks. All compounds protected too under patents!

Regards

Good morning Potnak, I am not sure if I have missed out on something here. Are we definitely going to run 1801 CTA alongside 1802? As I understand it both compounds may prove to be selective enough against Covid to be prescribed as a treatment. With having two compounds at least in trials who will be funding this as costs will be nigh twice as much.

As I say, I may have misunderstood something. Perhaps paying too much attention to Tim's we are looking to on license one of our compounds which we are looking at 1801 ( June 2020)

With regards to a 3rd candidate, it is very probable. Our compounds have the ability to be tweaked for selectivity. Not easy ( I would hazard a guess at looking at an updated SKIL platform) but bearing in mind Sareum been looking at this for nigh a year.

Regards

I have bought at over 80p, but only a few thousand. I have a few more in 50's and 60's. Probably add a few K more if not spend on a decent amplifier/speakers.

Regards

Castlepaul. Effectively and more importantly this is the only mask that affords good protection to the wearer too.

Regards

An RNS stating commencement of clinical trial should suffice. No reason at the moment that the compounds should not work. Testing has been meticulously carried out. 2nd generation inhibitors therefore do not carry the associated black box and warnings associated with 1st generation ( not selective enough).
Once clinical trial in place and its indications announced whether we run 1801 alongside 1802 and maybe 2 compounds from 1801 ( one tweaked a tad more for selectivity over Covid 19) then the SP will rocket anywhere upwards. The time is approaching very soon 6 weeks.

Regards

Doolinator.
Faith and belief have been here and still is for at least the past 9 years. After faith and belief have gone all that can be left then is hope. That is how I see it. Those that are very new to this game especially that come here lack understanding of the company and its pipeline. Not being judgemental just saying

Regards

Good spot Del. Meant to have a put 0.1 percent as is a thousandth of total shares. Yes is an insignificant amount. I see the p purchase of shares as a positive vibe.
Share price as Utahsaints suggests I reckon is about right where it is. Until further concrete news comes in that is about where we will stay. There are the 'if the products were that good why has no one bought them', or' why is the SP not worth more' brigade.
Pharmaceuticals are high risk. Even more so for a small company.
At 0.3 p last year gave our Market cap less than 10 million, at 2.4 p that is circa 80 million a seven fold increase. But in the big picture that is still saying that the company is only worth circa 80 million for1801/1802 and the 27% interest with SRA737.
Very much undervalued if you look at risk V reward.
We will get to know I feel the true worth soon enough. I for one am very confident.

Regards
I will stress what Tim said last year that entering trials in 1801 would see significant share holder value. You can take from that as you like. I see the SP doubling at least on that news. My opinion is all that is. That being enabled it will prove two things. Confirm/ prove low toxicity and indicate how promising it will be for treatment of Covid.
Until anything happens we have doubt and speculation.
Regards

Cobalt, most Coid related stocks are down a little. 3million ( circa 1%) shares added to the stock exchange on 18th. Nothing goes up in a straight line and people are cautious. When ever we have been above this SP we have retraced. Good if you can buy back in should it fall.
If you take a note what Tim said June last year. Looking to get into clinical trials with one of the compounds ( was not looking overly interested in Covid apart from Aavenue to explore) which would see significant share holder value.

We have vast potential in Covid and can get into trial with a grant. Doubt is the only drawback at the moment.

In the lead up to the lockdown restrictions being lifted, people are becoming very complacent. I carry out work for MOD and many people now not wearing masks in inside working areas in close to proximity to others, To coin a phrase they think it is all over.
Oddly enough two tested positive last week the first positive tests in over 2 months. Yes, money aside we certainly do need therapeutics. The virus mutates and will continue to do so. Without wishing to sound pessimistic. this winter may turn out to be one of the deadliest with regards to a flu epidemic.

Regards

Marmited. Unfortunately the good that has been done will now be undone. There is a predicted wave due this Autumn. It is just a matter of how serious it will be.

Regards.

Along the lines of the following RNS for Flt 3

http://www.sareum.com/news/press-releases-and-news/2013/total-voting-rights1/

No reason not to issue similar with regards to 1801.

Good morning Celtic. No problem. I got out my tree a bit. So apologies to all for that.
With regards to Ahfams question of news of patent.

A European patent has been granted for SDC 1801 .We Know.
We are at a phase now where we have been before ie. pre trial and hence now must be candidate selection. Normally, one candidate selected from the most promising is put foward for trials. Due to the current situation with the pandemic ( cost aside) there is no reason why a 2nd candidate ( specially tweaked for Covid
19 ) can not be put into trials. May be along the lines of 1801 and 1801C. There is scope within the compound to tweak for maximun effect. How to do so or adjust to fit I don't have a clue.

Speculation now. Not only may the molecule be able to halt the cytokine storm but a tweaked version, also promote/ promise full recovery.
Previously with Sareum and will refer to FLT 3 here , the compound had a couple of improvements made to the selectivity of the compound . We were informed before trials went ahead, of this particular candidate being selected and the reasoning behind it. There is no reason why Sareum will not do this again.
So to answer Ahfams question. My thoughts are that we will receive news ie patented molecule 1801 and a molecule adjusted or tweaked more favourably for treatment of Covid.
On a positive note here. Take the stage we are at with Tyk2 Jak1 inhibitor in autoimmune. There is enough known now about Covid 19, such that now is the optimum time to cross the t's and dot the eyes so as to speak with a Tyk2 Jk 1 inhibitor. Candidate selection RNS would not go amiss.

Regards all

Good morning Ahfam apologies for getting side tracked. I really have no idea when we would get news on secret patent. I take it this patent is for the crystalisation of compounds and not the already granted patent for 1801. We have info on the 1801 patent with regards to its now protected compounds and description. I must confess to have been looking for flaws in our compound or anything that might not fit. I can find nothing so far. All looks good. The sooner we can get some good from this and look after and treat people on this planet the better,
bed time
Good night all!

I could be way off here, but if it is crystalisation of compounds it should put FLT 3 back on the drawing board

Basser i certainly will not miss the tripe you write. there was evidence of which I have no problem putting you right on. What you think or have been led to believe and what you actually know of fact are very different. One sided stories. Depends on the source of information. However, block me; please do and put your head in the sand.
On that note, Wish you a good night even though we have different political opinions.
Regards and good luck in your investments Basser.

Looks like you are getting desperate to malke an arguement you are out your depth on. Why would I be saying that a man never landed on the moom. What sort odf arguement is that. First men was Neil Armstrong 2nd man was Buzz Aldrin, What point you trying to make?
If you want evidence then you only have to look for it. If you want to make an argument with evidence then I will make it. Was it true that in Some Biden won states that there were more votes than eligible voters? A simple yes or no will do?

If you are regarding political views then that is my perogative. So why do they need to know my political views. What difference does that make? Does it make my judgement any better or any worse than others here?