Member Info for sadoldgit

Hi Ahfam.
I would add with regards to Sierra my view is that they are so financially constrained by Momoletonib that they are hanging on to this, 'exploration of alternative financing for the continuing development' of SRA737 for as long as possible, They need get shot of this I feel before they can continue development.
Sierra I believe paid 3 million up front with a further 185 million in milestones. I dont know how much they have paid Gilead in milestones so far. Sooner or later they will need to act. T2 suggested a 12 month timescale, After 12 months do they return to CPF? How enforceable is the agreement Will the CPF grant perhaps a shorter extension? Is it likely to go into a legal battle?
Of no significant impact I see it with regards to having any negative impact at the moment with regards to Sar on SP as have sufficient funding at least the next 6 months plus.
I would guess at later stage discussions in place for success of 1801 with respect for Covid and possible on license and royalties, or on license of 1801 for non Covid applications.
There will be more than one interested party!
As for market cap I would estimate 250 million upfront minimum for non Covid target and a minimum of a billion upfront should 1801 be a success. This may not be realised till a little later on in the year, but I am confident that Tim and co have all possible eventualities covered.
I may be talking out my ar5e. I may only have a quarter of the shares of the 900k investor but I have obtained them at a quarter of the price and just if not more so confident as he is. Be nice to get a few bob as need some new ball joints fitting to the V70.

Regards and hey ho.

Just to add for the new additions to the board.
Tyk2 was recommended by the WHO as a potential way forward for the treatment of Covid 19.
There are 4 Janus kinases ie Jak1, Jak2, Jak3 and TYK2
Jak 2 and Jak3 inhibitors exhibit serious side affects hence the NDA black box warnings for these classes of inhibitors.
WHO does not recommend the use of Baricitinib or Remsdisivir alone. ( No indications here of any significant improvement in their solo usage).
Pre clinical development and Sareum will need to provide one candidate and possibly 2 candidates for clinical trial. It has been postulated by some that there may be an enhanced compound for the purposes of Covid 19. If we take into consideration pf the then known problems of the cytokine storm and causes of associated with Covid back in April last year then this would indicate considerable groundwork has been done to date by Sareum with regards to finding an effective treatment. Tim and co appear very confident, as would the individual high net worth 900k investor.
The next few weeks should prove the outcome of this.

Good luck ( not that we need it) and all the best, to all long time holders and the not so long time holders,

JAK inhibitors
The key role of JAK-STAT–mediated cytokines, such as IL-6, IL-10, and TNF-a, in the severity of COVID-19 suggests a role for JAK-STAT inhibitors in ameliorating disease severity.95 However, blocking the JAK-STAT pathway strongly inhibits IFN signaling and decreases T-cell proliferation and response.45,96 Because IFN signaling is instrumental in initiating the innate immune response and in preventing viral replication, JAK-STAT inhibitors should be avoided during the very early stages of the disease.97 Because preventing the (IFN-triggered) cytokine storm would be highly desirable, attenuating JAK-STAT signaling could very well improve disease outcome when such symptoms are occurring. Indeed, preliminary data from COVID-19 patients treated with the JAK inhibitor baricitinib in the early phases of their disease demonstrated improvements in inflammatory symptoms and in pulmonary function tests.95 Ruxolitinib treatment was also proven to reduce severe systemic hyperinflammation in a pilot study, with more extensive phase 2 testing underway.98 Because JAK inhibitors affect T-cell skewing and function, inhibition of an adequate T-cell response to secondary infections might be expected upon prolonged treatment.45 The JAK inhibitors baricitinib, ruxolitinib, and tofacitinib are being tested in clinical trials

I recall Tim making referral to Interferon gamma signalling and control of in one of his earlier interviews with Andrew Scott I think.. My opinion is that they have cracked this, Clearly there will be no mention of how this is done at this stage if indeed it has been done.
In addition unlike Baricitinib, SDC1801 it does not contain JAK2 hence none of the severe black box warning severe side effects should be encountered.
The absolute worse case scenario as far as I can see is that SDC 1801 suitable for treatment of severe Covid 19 conditions.

If we look at current pandemic there are two outcomes,
It takes turn for the worse, in which we will certainly need this type of treatment to save lives, it would lessen the burden on our all important NHS.
Should the pandemic miraculously go away the government will still need a contingency plan to a protect human life and secondly ensure that the economy is not bought to a standstill. How many billions have been spent on additional hospital beds and ventilators?
Should SDC1801 prove a satisfactory treatment for severe covid 19 alone then it will be imperative that the government has suitable access to supplies if and when it may be needed. A very realistic outcome here will be that what Sareum has can and may lead to the UK bring the first country in the world to properly get back on its feet and free from the economic restraints and threat of severe loss of human life.

That being said SDC1801 still has massive potential for the immunotherapies outside of Covid 19 that it was intended for.

More money in the bank and delayed expenditure.

Bought at 2.8 p. It removes the immediate need for a milestone payment. On the basis of the RNS we should see a nice blue day.

Intrigued how the high net worth individual reached this deal. Somebody knows a little more than we do me thinks.

Just to add heartfelt thanks for the condolence messages sent by you lads and maybe ladies.

Tuna has an objective. His information is incorrect and twisted. It has a slant on it to deter investors if you can cut through the barely intelligible grammar.

Than the year 1981flu the Spanish come, the masks gas mustard worn WW1. Follow after the year 9191 the return of spanish flu more the kill than the war. Wave the predicted year towards of late year. Will be worn the mask. Variant Indian the spread the wild fire like.

Degadres

Only to be expected fearg. As has been mentioned before viruses have the ability to mutate. Recognition by our immune system is of the protein spikes. The protein around a viruses is made up of over a 1100 amino acids. The nucleic acid ie the RNA in the case of Covid 19 will adjust in its objective to survive. It will in an effort to hide from an immune system alter its spike protein.

I will add i have had enough of looking into the immune system with regard to interferon gamma. There is more than one route to the control of interferons IL10 also involved in production of. The deeper you delve into the more complex i have found it has become.

My views are we are looking pretty good and should have no problems going into clinical trials. The result of the first trial should indicate the level of success we have.

To the relief of some I will not be posting on here for a bit. My young brother in laws wife who was just due to give birth has died and so has the infant within 12hrs of each other. Complications resulted in Cesarian section. Both in hospital, both dead, both have Covid and both will be buried in same coffin. Tis in Philippines. Fortunately am in possession of some money to help pay around 5000 pounds in hospital fees so the bodies can be released for burial.

Regards.
Regarding our TYK2/Jak 1,Tim knows more than I will ever know with potential for treatments on this subject so I think best left in the hands of the expert himself.

Best post of the day citizen. I laughed at first then after a little ponder began to think this is a great idea. Had never considered taking a pill in the preventative sense. Why treat when you can prevent in the first place.The excitement of such a prospect is mind boggling. The world heading back to normality!

Almost incredible but, reckon achievable if continuing successful results.
Regards

Was it not Boris who stated whether jokingly or not, to have a pill by Autumn?

12 to 14 days before the body develops antibodies to virus and possible./probable cytokine storm. All prevented by a fast acting kinase inhibitor.

Again great post Citizen!

Carter 19.
Vaccines are not the be all and end all. Am of the belief that the vaccine will tend to lead people into a false sense of security. Vaccines we know, are not 100% effective, The virus will learn to evade these as part of its capabilities to mutate to ensure survival. Vaccines designed to prevent infection and or limit the effects. Viruses evolution is to mutate and escape detection.

As bacteria have become resilient to antibiotics ( the main cause of this is people not taking the full course of antibiotics, they feel better after a few days and stop. The end result is there is now an element of bacteria that has built up an immunity to the particular antibiotic). Now for viruses. Viruses will harden especially when subject to ultra violet light ( present in the suns rays) not enough to kill all, and those that survive will mutate in an effort to become resilient to their environment. That is one of the reasons why I feel the worst strains come from sunny climates.

If we take vaccination of people now. Lets assume that someone already has early stages of the virus and are then vaccinated. Do you not think, that the cells that were infected with the virus now being subject to a vaccine will attempt to generate its own of defence. One form to ensure survival is to change its spike protein. We now have a newer strain which will be evading the early detection ( it is trying to hide) by our immune systems and production of antibodies. In effect mutations happen minutely even from person to person. Eventually the new virus protein is a long way from the protein that was in the vaccination. The vaccine provides id of the virus protein and not the nucleus)
How long does it take to vaccinate the world? In the ideal situation the whole world would be vaccinated in a very short space of time for the latest and most destructive strain of the virus. Over 14 billion vaccines in a 3 month period? Is it any wonder a respected specialist stated it is just completely useless.

I do not know about yourself, but I just cannot see this happening. The vaccination will always be one step behind, always playing catch up. On top of this, will Covid 19 be the last pandemic we will see? Unfortunately for millions the answer will be yes.

Vaccinations at best now 90% effective. that leaves 700 million people. At between 10 and 20% fatality rate that would lead to 70 to 140 million deaths. The virus will continue to mutate as long as it is in circulation. How we remove it from circulation I do not know, How long for herd immunity? Five years, ten years or maybe longer does anyone know the answer to this?. For those that have contracted and not proved fatal, then how many have long term covid? Damage to lungs, kidneys and heart to name just three.

Effective treatments will be required for covid19. Even if ours is only one of many, it will be a success . Looks very promising from Tim an Co's comments.

Regards

You talk about smarmy. Too far up your own backside to admit to an insult I have just pointed out to you. Just about sums you up;
Pity really as some of your posts are good.

Fadec, I had already realised that TLL 018 is a dual (not duel ) Tyk2 Jak 1 inhibitor. So no problem there. If you want to be so infantile to think you have proved me wrong then go ahead with that. However as I interpreted what you had posted appeared to me that you were referring to ICP-22 and not TLL018.

I apologise for the 'dig a big hole' as would appear that i have misinterpreted your posts. I can assure you I am nor smarmy.

However I do find your posts of I should research this and that and I have no excuse equally insulting.

Now your turn to apologise!

Only 14hrs old report

With Covid second wave gaining momentum, a report by TOI has revealed that there has been a sharp rise in the death of young people in Karnataka.

The second wave has especially been brutal on the younger generation of the country with many families witnessing the untimely death of their children due to the virus.

Nearly 56% of deaths due to Covid-19 in the 20-49 age group in Karnataka have occurred in the past two months. Of the 4,432 victims in the 20-49 age bracket so far, 2,465 died between March 17 and May 17, reported TOI.

As opposed to the first Covid wave which rarely led to severity among the younger crowd of India, the second toll has exacted a toll with nearly 30 percent of the ICU beds being occupied by the young, said Dr. Mahendra Kumar, medical director of Sagar Hospitals to TOI.

No sign of this flu going away anytime soon. Reinfection is becoming more common.
Herd immunity regarded by some as pointless due to reinfection. An excerpt from a WHO report below,

Globally, data from seroprevalence studies suggests that less 10% of those studied have been infected, meaning that the vast majority of the world’s population remains susceptible to this virus.

For other coronaviruses – such as the common cold, SARS-CoV-1 and Middle East Respiratory Syndrome (MERS) – immunity declines over time, as is the case with other diseases. While people infected with the SARS-CoV-2 virus develop antibodies and immunity, we do not yet know how long it lasts.

Goolinator. from your last post, you still have not contributed any thing of use. We have our opinions and posts of what we believe as factual information which we will defend and argue. You do not know what I think. i am merely being precise. Opinion is not the same as think. opinions are important thoughts are not so.
Little conversation was over and forgotten before you stuck your tuppence worth in

Tata

The point I was making was the ICP 322 no indication of being a Tyk 2 Jak1 only Tyk2.
I were not referring to TL018. Which is of course a Tyk 2 Jak 1 inhibitor.

In what capacity are in you to tell me what I should be doing? If you were a little more clearer with regards to which particular compound you are referring then I can of course research this. 'No excuse' you say, It is not an excuse. it is my opinion

Just to correct you. It is my 'opinion' and not what I 'think' that you are a deramper and ramper when it suits you. There is a difference . Perhaps you should take time to research the difference between the two. There is a difference between opinion and think.

Many of your posts I find interesting to read and look further.

But, please do yourself a favour Fadec and don't be condescending by telling me what I should be doing.
Regards

Hello again Fadec. You state that TL pharma is more like a dual Tyk2/Jak 1 inhibitor. From which source of information substantiates this similarity? Surely it is either Tyk2/Jak1 inhibitor or not.

Before you dig a big hole for yourself are you stating that you only post facts and nothing else?

Regards.

Fadec you seem very keen on this ICP-332. Tell why your constant phase. You say you state facts. However you state phase 1 trial should have been completed. Not a fact as such. Has it been completed or has it not been completed. Do you know the answer to this?
Looking through your previous posts l have observed negative and positive comments dependant on how the share price is.
Does your beloved ICP-332 contain Jak 1? Do you know or dont you? You state the similarity to our SDC 1801 TYK 2 JAK 1 inhibitor then go on to mention the claimed 400 times selectiveness of their Tyk 2 over Jak 2. Disparity when it suits you. My opinion from my observations of your posts put you as a serial ramper and deramper to suit your own agenda.

Feel free to block, as l will put down what l feel is the truth and factual.

You seem very keen on this

Matblack. We have our own molecule that is now covered by patents worldwide. That is all that matters. Our molecule is a Tyk2 and Jak1 inhibitor. We are more selective than Jak2 and Jak3.

Only area of concern for Tim was control of Intreferon Gamma. All other indications look covered to me.
As regards fir immunotherapy targets l would advice surfing through Sareums patent application and granting of. If people cant be bothered to research this, then they should not be placing doubt in other peoples mind or be invested here unless their primary objective is a short or after selling trying to get back in at a cheaper price.

Regards and try to do some of your own research.

Tyk2 is more selective than Jak2. Jak3 inhibitors also require Jak1 to run in Tandem
SDC 1801 is Tyk 2 and smal amount of Jak1.
Tyk2 has no to little toxicity. In this case amount of Jak1 can be increased by increasing amount of 1801 administered. Tyk2 and Jak1 can target same areas but do do via different STAT pathways.

Steadydanny, sorry, forgot to add, try looking at Ahfams post from 11th of May.
Regards.
Nothing has changed