RE: Thank you LTH’s13 Jun 2021 01:31
elliot. Indeed TYK 2 Jak 1 compound should be effective in trearting MS, an excerpt from SAR patent description
Symptoms of multiple sclerosis that may be eliminated or reduced in severity in accordance with the invention include any one or more symptoms, in any combination, selected from:
¦ weakness and/or numbness in one or more extremities;
¦ tingling of the extremities;
¦ tight band-like sensations around the trunk or limbs;
¦ tremor of one or more extremities;
¦ dragging or poor control of one or both legs;
¦ spastic or ataxic paraparesis;
¦ paralysis of one or more extremities;
¦ hyperactive tendon reflexes;
¦ disappearance of abdominal reflexes;
¦ Lhermitte's sign;
¦ retrobulbar or optic neuritis;
¦ unsteadiness in walking;
¦ problems with balance,
¦ increased muscle fatigue;
¦ brain stem symptoms (diplopia, vertigo, vomiting);
¦ disorders of micturition;
¦ hemiplegia;
¦ trigeminal neuralgia;
¦ other pain syndromes;
¦ nystagmus and ataxia;
¦ cerebellar-type ataxia;
¦ Charcot's triad; diplopia;
¦ bilateral internuclear ophthalmoplegia;
¦ myokymia or paralysis of facial muscles;
¦ deafness;
¦ tinnitus;
¦ unformed auditory hallucinations (because of involvement of cochlear connections);
¦ transient facial anesthesia or of trigeminal neuralgia;
¦ urinary and/or faecal incontinence
¦ bladder dysfunction euphoria;
¦ depression;
¦ fatigue;
¦ dementia;
¦ dull, aching pain in the lower back;
¦ sharp, burning, poorly localized pains in a limb;
¦ abrupt attacks of neurologic deficit;
¦ dysarthria and ataxia;
¦ paroxysmal pain and dysesthesia in a limb;
¦ flashing lights;
¦ paroxysmal itching;
¦ tonic seizures;
¦ changes in sensation;
¦ visual problems;
¦ muscle weakness;
¦ difficulties with coordination and speech;
¦ cognitive impairment;
¦ overheating; and
¦ impaired mobility and disability.
The compound may be used in a prophylactic sense during periods of remission in order to prevent or reduce the likelihood or severity of relapses or it may be used to treat patients who are suffering from a relapse. Preferably it is used in a prophylactic sense.
Regards