Member Info for sadoldgit

Only just read the latest RNS. Well worded and of particular note worth mentioning is the following extract:-

'Initial studies, using isolated human lung cells, are encouraging and show that SDC-1801 does indeed downregulate the increase in cytokines believed to be responsible for ARDS and the cytokine storm following infection with SARS-CoV-2'.

Use of the term 'does indeed'. Cannot get much more indicative than that of 1801 effectiveness with regards to cytokine storm. No massive ramp of an RNS in anyway shape or form. But the indications are there of the potential is there and slowly but surely the 'ifs' are being replaced with 'does' and 'is'.
Sierra and 737 still plodding on hard each and every day with their exploring options of how to fund further development after a year and not produced anything, nothing to do with the potential of 737 in any way at all I might add. They need stump up money for milestone payments which they have already negotiated a reduction for in an effort to continue trials in patients.
All in all looking very very bright.
Regards

Num4, good post, shows TYK2 is preferred approach. Interesting read.
Regards

Very interesting listen on the radio whilst driving home. of special interest is taking a pill.
1.Vaccines are not taken in pill form.
2 There is not and will never be 1 vaccine fits all. The virus mutates. Current vaccines will loose effectiveness.
3. To stop a condition in its tracks will require inhibition of the cytokine storm and the damage from over reaction of our immune systems.
4, Ready for Autumn in preparation for predicted 3rd wave so Boris says.
5. I can only deduce that Sareums TYk 2 compound in current timeframe is looking very favourite.
All in my opinion
All the best to all here!

I cant buy 10k or 1k. So much for supply and demand.

The 50k shown as a sell is at time of transaction a buy.

Agreed there Bouchos. Some think it is akin to going in a supermarket and purchasing a box of soap powder. It takes time typically around 6 to 9 months. I was told that many years ago by a friend who is now sadly not amongst us. Covid 19 will cause delays that are inevitable.
Down side is, on no news the share here will slide , the derampers come out in bunches like piles and have a different agenda to you and me.
They can do nothing constructive and are therefore destructive either to try and buy in lower or they are shorting. They are not investors at all in my mind.
if price should go down a tad more I ain't bothered and most likely add a couple of million or so.
Regards

LP
Volz, certainly does not mean people. Volks translates to people hence the car Volkswagen translating to peoples car.
Volz in English I believe but not 100% sure means a descendent. Many years since I learned German and worked with German people.
Very apt here at times would be the German word 'Sheisserkopf'

Regards

Hi Lazarus. Sierra are around 6 hours behind us. Not think we would hear anything about them for a couple of days at least. Excellent results in combo , but no mention of from Sar. Waiting game unfortunately.
Be good to know what Sierra's game plan is and the cause of delays in furthering development.
Regards

Good evening Blastoid. Yes remmission is correct term. You are never cured of Cancer contrary to the belief of some here. Cancer cells can remain dormant. Normal cells have a life. Cancer cells do not they can live for many years.

After remmission Cancer can return normally within a 5 year period but can occur after this..

In most cases cancer can only be treated at the point of cell division and replication. CHK1 is extremely important in cell DNA damage response ie the effects of treatment on a cell and the cell and the way it behaves in an effort to survive and multiply. After all, the cell is part of our bodies and we have an immune system and the ability to adapt. The cancerous cells are mutations that we dont want. Waffled a bit my take on it.

All in all the best we can expect is remmission . In this sense SRA 737 with its proven low toxicity in combination with other therapies look pretty damn close to achieving just that.
Regards.

Good evening Num4 I cannot see any reason as to why Sareum should not release an RNS with regards to SRA 737 result presented at AACR by the ICR on Saturday.

Regards

CHK1 ie SRA737 can be researched under 'NCT02797964'. Apologies if this has been posted before.

Fadec, that was the exact thought I had. Perhaps maybe an alternation of therapies could be used to even greater effect. I doubt we are the first to think this.
ChK 1 has already been shown to be effective with Gemcitabine.
The full potential of SRA 737 has not been fully realised.
Regards

In my opinion AZN must be climbing all over the back of Sierra, closely followed by the ICR

Hi Num4. Delay tactics but the bucket load. They have cut funds from SRA737 research to fund Momoletonib. Sooner or later I feel that need to 5 hit or get off the pot.
Regards.

Damion. The link you have shown is from 2017. Since then CHK1 research has moved on 4 years. Perhaps you could also enlighten us on what other combos with 'our Chk1' previously presented at the AACR and have amounted to nothing.

With regards to Momelotinib, in Sierra report( much more recent than 2017 I might add) it has been stated that SRA737 may prove to be more commercially viable then Momelotinib.

With the SRA 737 removed from the SRA737 website ( ie not for sale) I can only deduce that SRA737 is worth considerably more than what some people here think.
Regards

Good afternoon Blastoid. Interesting graph to say the least. Interpretations and predictions can be made from graphs as we all know.
The down sides to the graph as I see it. 35 days and only 17 measurements. Points are plotted and as we all know the bars shown at the plotted points give the minimum and maximum limits and the lines have been plotted straight through the centre. (It will be difficult to measure the precise size of a tumour)
We can look at the graph and see plotted the points of tumour growth.

If we look at AZN alone we have an approx 330 percent increase in tumour size by day 30. ie Approx 0.25 at start and 1.15 after 30 days. I put here the increase as opposed to actual size.

If we now take SRA 737 and apply same methodology we find increase in size at approx 200% ie 0.25 at start and 0.7 after 30 days.

If we now apply SRA 737 and Astra Zenneca in combo we find a 25% reduction. This is no less than mind boggling as not only has the tumour growth been slowed but also been reduced. At the very pessimistic least there is no growth indicated at 35 days. The only problem that may effect this is I feel is how many cycles can be applied and their timing apart, and this will be down to the toxicity of the compounds.

Life expectancy on treatment should be drastically increased using this combined treatment.
As much as we can extrapolate the graph in its downward trend (look at tumour size around day 21 and draw a line from start to through this point) in the combo for the purposes of 'will it iradicate completely?' We can only make assumptions. Assumptions are no good at times in research and cannot be relied upon. Numerous trials need to go ahead with repeat treatments to prove not only the effectiveness of AZN, SRA737 but also the combo.
To summarise the results shown on the graph with AZN and SRA in combo over the 35 day period are outstanding! )
PS rough measurements were made not on a fag packet but a fag paper.
Regards and look forward to a great week.

Eurasianite. Good post. I would hazard a guess that before major production ie 24/7 goes ahead, orders after enquiries will need to be taken. RMS at full capacity I do not see as satisfying demand. In this instance I would think that there are communications with Volz. Lets face it, 1 million masks a month from Volz is not by any means a large order especially if we include Europe and America.
RMS have now gained MHRA approval which sets it above other masks. It will be a fine balancing act between orders and production.
If we take it that only 1% of people in the UK use one mask a day for a month that would equate to 700k x 30 equals 21 million. If we include Europe and the USA this figure would be substantially higher. The potential is there and I feel it is a case of being able to fill orders ie being able to manufacture enough to meet demands. A fourth wave is predicted here in Autumn. Vaccines are not the be all and end all by any means. The virus mutates and there is now a twice as lethal strain from Nigeria i believe.
Masks are not the be all an end all either. but in a multi pronged attack ie vaccinations, wearing of 'effective' masks and new treatments should stem the flow of the devastation both to human health ( 122k nursing staff in the NHS have long term covid symptoms) and the financial cost to the country in lost revenues caused by no work.

Regards

It is also good we have world wide patents for Tyk2.

Fb, why would you want a second machine if you are experiencing problems with the first one?
In addition you also need keep money for cash flow.
Furthermore why would you need another machine if you are only using the one you have for around 40 hrs pet week?
It all takes time ie orders, production targets and the ability to forfil large orders.
There are far more cleverer and knowledgeable people than you and me looking at this right now.

One thing we can all be sure of is the Coronvirus is not going anytime soon
Regards

Truth factory, since when is your opinion a fact? Half you muppets don't know what a fact is nowadays. Your mouth must bleed once a month.
Regards