RE: A reborn Val21 Jun 2025 14:09
I was just looking back at the history of 401 - it only had one peer review, and one of the reviewers was Suzy Dilly, so how much clout that carries I don't know, and the review is pretty shallow, mainly about safety tolerance and nothing I can see of significant clinical benefit being advanced.
Bear in mind also that the 401 trial involved very few patients and was carried out at a clinic at '6 Politkovskaya Street, Tbilisi 0186, Georgia', and the RNS telling of what results there are was released in November 2018 - coming up to seven years of silence on any clinical advancement, although to be fair PM2022 did tell me a while ago that Val doesn't do research any more, they are a lab company...
As far as the usual torrent at Porky9 by the way, it seems as unfair as usual because the much-trumpeted '16 million quid' is only subject to commercial and clinical milestones, and then presumably on something successful actually arising therefrom. So Porky's comments about a raise seem entirely likely - 401 has to be dusted off, defibrillated, manufactured, a clinic found, a series of patients recruited and treated, then monitored for some considerable time, results collated checked and published, and only assuming they are significantly successful could any reasonable financial inflow possibly occur. I can't see any great income even from clinical milestones, and at the most optimistic that has to be some 12 to 18 months away, so what is going to pay wages, lab costs, drug costs and so on, not to mention bonuses which must surely be due if this is such a good move for 401.
Looking at Companies House, where Ambrose Healthcare seems to have just the one director, the other (a relative judging by the name) resigned earlier this year, I can't see them dipping into their own pocket as it seems their capital a few months ago was just over 500 quid.
Why not wait and see if Porky's prediction of (another) raise comes about, or if not then say where you think a good many millions will be dug up from and needed well ahead of even the first possible clinical milestone?