RE: abacus4 Oct 2021 16:32
ConsDoms, interesting name ;-D
One thing though, remember that Hemogenyx have multiple pipelines, one of which is CAR-T as you highlight but the other which is currently under licencing and commercilalisation talks with Eli Lilly is CDX.
CDX is interesting because as per the patent and multiple RNS updates it has multiple uses, the first one, like CAR-T is the treatment of AML, which as you highlight has a massive target. But the bigger picture here is that not only does it wipe out AML cells it can also be used to wipe out a patents Bone Marrow stem cells. https://tinyurl.com/yspjv89w This means in effect CDX will work against (Taken from US Patent:):
Acute myeloid leukemia (AML), acute lymphoblastic leukemia (ALL), chronic myeloid leukemia (CLL), CML, peripheral T cell lymphoma, follicular lymphoma, diffuse large B cell lymphoma, Hodgkin lymphoma, non-Hodgkin lymphoma, neuroblastoma, a non-malignant inherited and acquired marrow disorder, multiple myeloma, or SOD. sickle cell anemia, beta-thalassemia major, refractory Diamond-Blackfan anemia, myelodysplastic syndrome, idiopathic severe aplastic anemia, paroxysmal nocturnal hemoglobinuria, pure red cell aplasia, Fanconi anemia, amegakaryocytosis, and congenital thrombocytopenia.
Basically anything that today is a cancerous mutation of BM stem cells and is currently treated by toxic chemotherapy can be treated by CDX and BMT. The market is HUGE, its bigger than the current market because at present the patent pool excludes the elderly and those too ill to undertake chemotherapy as they would be unlikely to survive but would survive CDX. Faster, less side effects, less toxic, targeted treatment rather than a carpet bomb approach as is used today.
Yet again feel drawn to point out despite this mCap is 19mil.... Madness!