The latest Investing Matters Podcast with Jean Roche, Co-Manager of Schroder UK Mid Cap Investment Trust has just been released. Listen here.
Managing investors and share price is part of the deal of listing publicly. I though it was weird Mandy now saying they no longer respond to individual investors on the investor email address recently!
If you get a huge boost of 100's of millions from investors, you need to respect that. Goes against your credibility to keep them in the dark.
My feeling though is that there's a reason for the silence and it's something big.
@Foxy, Cheers, not too far away then hopefully. You know how savage AIM can be after a spike in price and a period without news.
When is SNG's next trial, and how long will that last?
A lot of companies release an RNS to state they've started a trial. NCYT could have done that for the saliva study so we know they've definitely sat on that news at least.
Well yes there is that rumour going around that GM wants to load the news flow close to his bonus to get the share price as high as possible at that time as he benefits most.
Think it's Tom Winnifrith that started that. I can't see it myself, basically internally they'll have a timescale and we've just suffered a quiet period while they put the pieces together.
Two months isn't a long time in biotech, but it's an eternity on AIM!
Yeah basically there's a response, but no clue how long those antibodies stick around for, and even if it confers any protection from the virus.
Anyone that thought this vaccine was coming in September is way off. Pretty shady for Oxford to even suggest that recently though I guess ultimately it's about securing contracts and cash.
@flush
Omega had an investor presentation today and SNG had good trial results. Both deserved a good day, after the kicking they've had.
People are now excited about bagging in Covid stocks again and they're hunting for penny stock candidates. You've got the GDR's and such like. Even Hemo, not technically a covid stock, well maybe a shoe-in, has buzz today.
Novacyt is well past that stage, it's gone through the cycles and the market is waiting to decide what its fair value is and what's happening behind closed doors. GM has been really quiet. We're pushing over two months without any real news from the company. Every RNS since the £5 peak has been below market expectations in some way.
The good thing is, now it's had an absolute beating, we know a stream of positive news flow is coming. We need more than one RNS, we need a flurry of them to build momentum and hype. Hopefully something lands this week.
Today's red day isn't anything other than the MM moving the price up and down. It's how they make money every day.
Wait and see what they'll do to SNG at some point this week or next at the latest. There will be a bloodbath soon.
Really hope NCYT doesn't do an RNS this afternoon. Better for it to land during the handover from SNG and Omega later in the week when MM's shake them down and people pull the cash out looking for another covid play.
Guys SNG has had nearly 3 months of doom and despair and daily losses after its share price halved from 78p to 32p.
Imagine suffering that for nearly 3 months and holding on. Long term guys there really deserve the payoff.
NCYT's had a beating too, but won't be much longer now until it gets some actual news.
Looks like it, though this link looks like a Northern Ireland offer for tenders. Is NI's Belfast procurement office handling it for the whole of the UK?
"Business Services Organisation (BSO) Procurement and Logistics Service (PaLS), on behalf of all Northern Ireland Public Sector Bodies covered by the Northern Ireland Public Procurement Policy (NIPPP), is establishing a Dynamic Purchasing System (DPS) for the procurement of both disposal and re-usable Personal Protective Equipment (PPE) and other Associated Products."
IV.2.2)
Time limit for receipt of tenders or requests to participate
Date: 25/06/2025
Local time: 15:00
Well all those guys trapped in the high 400s in Novacyt will be looking at SNG today and doing a little happy dance. Proof the price can return to and exceed previous highs once the company meets expectations.
Though there will be guys buying SNG this morning over 100p who might be feeling a bit hungover in a few days! Brilliant day for them though, Omega doing well too. Fingers crossed for some Novacyt news this week!
Novacyt's been a busy bee.
They're working both angles - novel PCR methods and turnaround times while also developing saliva extraction. That saliva study was a while back, I bet they're running another saliva trial with a slightly different method that's aimed at detecting low viral loads by now. Could even have a bunch of them ongoing, with slightly different methods.
Either way, it shows you why swab testing PCR is the workhorse. The world relies on its accuracy when the swabbing is done right.
What we need now is Valley Floyd to keep investigating saliva studies as they get published, because we're all behind the curve here. This stuff is already old news, but no-one saw it. God knows where they're at now.
It's a disaster in the US. Much worse than anything we have here. Testing I mean. Colorado Gov. today complaining that they're lucky if to get a test result back from a private lab in up to 9 days! They're desperate for a proper private testing regime that can turnaround results within 48 hours.
------
The US national testing efforts have been described as a “complete disgrace” by Jared Polis, the governor of Colorado and a member of the US Democratic party.
Speaking on Meet the Press on NBC News today, he added:
So, every test we send out to private lab partners nationally, Quest, Labcorp, seven days, eight days, nine days maybe six days if we’re lucky. Almost useless from an epidemiological or even diagnostic perspective.
Fortunately, our state lab has done yeoman’s work. We’re running three shifts a day there, 24 hours a day. So while some are still sent out of state, and unfortunately that takes a long time and we can’t count on it and our country needs to get testing right, we’re trying to build that capacity in Colorado to process tests at that one to two-day turnaround.
Which means this NHS Southampton study will might not be as likely to produce the go-ahead saliva tests are looking for:
https://www.gov.uk/government/news/new-saliva-test-for-coronavirus-piloted-in-southampton
Could either be a boon or it could be a complete disaster. Bit of a gamble now if you're riding your hopes on a saliva test.
Had a look for media articles, and it seems been reported already that saliva from lower viral loads is less sensitive:
https://theconversation.com/explainer-whats-the-new-coronavirus-saliva-test-and-how-does-it-work-141877
Ah Jeez look.
Go through the studies again focusing on inpatient or outpatient/mixed studies.
https://www.hiqa.ie/sites/default/files/2020-06/Evidence-summary-for-salivary-detection-of-SARS-CoV-2.pdf
All the studies show the same thing if you view it from that angle. Inpatient studies are much better than outpatients/random participants.
That's what's slowing down saliva tests I guess then, they poor compared to PCR at detecting low viral loads.
Anyone got a more nuanced take on it?
Original study. Had a quick scan:
https://www.medrxiv.org/content/medrxiv/early/2020/05/15/2020.05.11.20092338.full.pdf
Some takeaways.
Saliva studies have been showing good sensitivity some on par with PCR.
Primer Design saliva study didn't find this level of sensitivity seen in previous studies.
Difference likely explained due to difference in patients used. Previous saliva studies focused on inpatients with high viral load. Primer Design study was mixed inpatient and outpatient, with a great number of outpatients with lower viral loads.
Conclusion - saliva maybe be good for high viral load patients and either more studies are needed, or new extraction techniques etc need to be used to detect CV-19 in lower load patients to match PCR.
Difference
Does look like it, will go over it in full tonight:
23 June too, so they're weeks ahead by now:
https://www.hiqa.ie/sites/default/files/2020-06/Evidence-summary-for-salivary-detection-of-SARS-CoV-2.pdf
@ Bramley
And then there's Iran with their bizarre claim of 25 million infected. They went from seemingly suppressing numbers to claiming to be the worst afflicted. Locations like that really need a strong WHO presence and testing regime to get some sort of idea where we're at, though guess Iran isn't the easiest to deal with.
@ Quickdraw
Climbing for me too today, though I'll be doing it on the bike, much less risky than hanging on to rocks with a couple of fingers! Lockdown wasn't kind to my waistline, need to get some miles in.
@ Seadoc Yeah it's a bit light on detail, I'd be interested in seeing what he thinks about the Cambridge study showing antibodies peaking after just a few weeks. His herd infection numbers look super optimistic too.