RE: Sky news12 Jun 2023 18:53
No reply from Sky news.
Joking aside. I’ve looked at the met Forman data. I remain unconvinced.
For primary endpoint of progression to severe disease- Nil to suggest metformin favourable. Multiple secondary endpoints trawled and just this one positive. In discussion they say they applied a Bonferroni correction and still statistically significant though no data given. Groups poorly matched at baseline which would favour poor outcome for placebo.
Bottom line- interesting that Sky would run the story, interesting that published in peer reviewed journal but globally unconvincing.
SNG- pre-hospital, incredible results from 2xp2 studies. P3 in hospital strong signal of benefit but underpowered study to detect meaningful outcomes.
Biggest headwind facing SP is that Covid isn’t perceived as a problem anymore but the the need for a host directed broad spectrum, variant agnostic antiviral hasn’t gone away.
More patience needed from shareholders. Universal trial should shed a bit more light on the magnitude of this unmet need.
I don’t disagree with “de-rampers” that share is quite speculative just now. One thought is that being on a Covid trial recruiting right now when Covid isn’t causing major problems is probably not in the long term interests of SNG or shareholders. Come the fall things may be rather different so being announced in the next couple of months would be ideal and give the speculators a boost.