RE: US Dems' final Covid report! hearing from Rick Bright13 Dec 2022 17:21
I’m with you Doc. Positivity based entirely on the positive data we have to date. I do recall the good Dr Castro from Kansas, who was very positive on SNG, saying it would be hard for SNG to find its niche in regards time from onset of symptoms, patient subgroup, outpatient or inpatient.
My feeling is that synairgen team were right just after release of the at home phase 2. They suggested that SNG would be best targeted at home for those with breathlessness.
In my mind that is the trial we are really looking for. Antivirals tend to have bigger effect given early. I think the in hospital was just underpowered but the effect size was smaller circa 30% RRR on the whole though again with the intriguing suggestion that the more breathless got bigger effects.
Bottom line I remain positive but it has to be the right trial, in the right circumstances. Omicron is not the right covid for SNG to be tested on- not that many people get breathless, have bad pneumonia or end up in ITUs. It’s tough sitting on big paper losses but I’m optimistic that the therapy works well and if that can be demonstrated then we are all on a huge winner. In the meantime it’s a tough lesson in patience.