A Logical review10 Nov 2020 17:35
The literature shows the latest most potent influenza vaccine has 50% efficacy and hospitals although not under the same extensive strain as years ago, still have a higher and older demographic population in the UK and on a mild infection rate year will still receive over 600,000 older than 65 years for actual hospital admission stay or around 2000 patients per hospital or around 250 patients in stay on wards at any one particular moment on time in the peak two month phase in the NHS. A very heavy epidemic would be 3 fold those figures as seen in late 2017 early 2018. Of course the entire population is not immunised for influenza, but it has a huge degree of herd immunity from previous years of influenza outbreaks. It is maintained by young people getting influenza and recovering normally.
So if a Covid-19 vaccine arises the key efficacy data to look for is the over 65 year old patients. If we gave the influenza vaccine to everyone in the population the efficacy rate would be 90%. As 19% of the UK population is over 65 years and if all positive cases were in the over 65 years group that 90% efficacy actually becomes 50% as 9.5% + 81% = 90.5%. So age ranges in the Pfizer study means everything. It is still handy to protect half the elderly population that could die of Covid-19. It would also convert the mortality rate from Covid-19 as being equivalent to a middle range influenza pandemic. The vaccine does allow the economies to open up. However, the Synairgen product was for the other half likely to take up hospital beds. If it has an efficacy that recovers many of those severely affected it saves 1000 patients being in any one hospital ill or at least that is what we hope is being proved in the stage 3 clinical trial.
The upshot is that Synairgen had a therapeutic market for the UK alone of around £200M plus a year and quite possibly £1B in overseas market. If profitability was just £50M after all cost at a PE rate of 8 for a small company on its current share base is £4 share price. Synairgen was never really a population treatment application, it was specifically those arriving in hospital in time to have value from being prescribed the product. It has potential of possibly limiting long Covid and it may be safer for older patients to have. The cost of treatment and being able to return home on discharge quickly makes it cost effective for healthcare providers. This scenario exists with or without a vaccine being available as Covid-19 attacks more specific vulnerable groups in the populace.