Member Info for tomvisual

Kainos, no harm being invested in other shares!
Its no secret I am invested here!
Its no secret the Innova LFT won the first tender to supply the NHS as per the post your reposted.
The next tender closes Wednesday 25th Nov!
£912M.
Thats what the play is here.
Have Avacta have tendered and will they have an LFT for January ?
That's the £912M play everyone is betting on!!
TW et al!!

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Well heres hoping to some of that £7B or is it £912M.
Wed is tender closure!
Lets see if Avacta win a slice if the cake!!

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CO,
I am wondering just what AVACTA is exposing their Lateral Flow test to:
* Is it just spike proteins, without the rest of the viral particle? Is just spike proteins possible? I can see that just spike proteins might be safer than whole viral particles.
Thinking about the conversion factors between the units:
* If a viral particle had a mass of 10^-15 g, including all its spike proteins, then I am thinking that the mass of a single spike protein must be much, much, less than 10^-15 g.
* The previous bullet point might suggest millions(?) of viral particles per ml for Avacta.
But the reasoning may be wrong!!
If Avacta is say >300,000 viral particles per ml, then sensitivity will be better than Innova. That's good enough reason until tender closure results for me!!
Recall Test sensitivity is secondary to frequency and turnaround time for COVID-19 surveillance.
https://www.medrxiv.org/content/10.1101/2020.06.22.20136309v3
and the Harvard presentation:
https://m.youtube.com/watch?v=h7Sv_pS8MgQ
So apparently a sensitivity of 50% is acceptable for mass testing!
Well knowing this and knowing that Avacta's sensitivity should be empirically better than the Innova LFT has told me to add to my investment in Avacta today!

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Well looking at Ophidians Twitter feed ge is bullish about BBI and Wednesday contract closure!
If the reliance is daily testing for 7 days in lieu of self isolation then the sensitivity has to be better than 57% in my book! This leads me to think Avacta are in play!!
Lets see how this progresses!

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Sparta, presentation at
https://avacta.wistia.com/medias/30w6vgnvmg

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CO, I recall a conversation with Ophidian on this BB sometime ago (9/5/20 to be exact).
Ophidian advised there is no conversion for copies/ml to PFU/ml.
You plot a response curve and read off it for a particular virus.
The sensitivity is generally referred to as being the slope of the calibration curve and the LOD is the intercept!
Ophidian was also unaware of any information pertaining to the LOD for affimers at the time if our BB discussion.
Pity he left the BB!

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Sir John Bell on R4 World at One 23/11/20 @13:40:
We will always have covid with us!
Govt needs to continue to do mass testing with LFT!!

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The £912M tender ends on 25th Nov. When is the LFT required? Dec, January??

Howany samples test assays are needed for clinical evaluation??
1200 seems to be the required number.
" All LFDs were assessed against 1,000 known negative samples in viral transport medium (VTM) and 200 banked known positive VTM samples that had previously been frozen"
See Innova results:
https://www.ox.ac.uk/sites/files/oxford/media_wysiwyg/UK%20evaluation_PHE%20Porton%20Down%20%20University%20of%20Oxford_final.pdf

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From
https://avacta.wistia.com/medias/30w6vgnvmg

The swab goes in the sample buffer tube and tgen a pipette must be used to apply sample to the LFT application window!

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Swab orthe spit + reagent is the mechanism used to apply a sample to the LFT from a pipette.
See SirAL's presentation today
https://avacta.wistia.com/medias/30w6vgnvmg

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Poundcake, from https://avacta.com/wp-content/uploads/2020/06/Placing-Presentation-June-2020-1.pdf
Results from Avacta LFT is MINUTES (page8)!!

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Wyndrum, not so sure...
Listen to R4 Today (23/11 @ 6:53). Msss testing aims not to use PCR. But the innova sensitivity is prrhaps 57%+. So could the Avacta LFT with improved sensitivity be the answer for daily testing to reduce self isolation?
Its easier to make the case IMHO!
All LFTs have compliant specificity.

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Benben, < 300 pg/ml!!

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Was the Liverpool study the Innova Clinical study?
If it was could Avacta be involved with the daoly testing over the 7 day isolation period??

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Usaon, Lets see if we win an order from the tender!!
Sensitivity isfor coronavirus spike protein in laboratory samples better than 300 pg/ml which is in the range expected for spike protein in clinical samples. The test is specific!
Have we met MHRA Guidelines Desired Criterion?
If so complementary PCR tests are not required!
Listen to R4 Today (33/11/20 @ 6:53)! With 7 days of daily tests PCR tests are also not required!!

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DOH85, absolutely, TT complete!
A highly scalable test device using readily available components and routine manufacturing processes has now been shown to have a sensitivity for coronavirus spike protein in laboratory samples better than 300 pg/ml

full clinical validation on the final product to support the regulatory approval process.

Have we bid for the tender?? That's tge question for me!!

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I wonder if Boris gas played a blinder. First almost cancelling Christmas and Santa Claus and now eith mass testing via LFT allowing those who test negative to be able to go about their lives as normal. After seven days of negative tests they will be released from the system!
Lateral Flow Test have worked! But in conjuction with PCR testing! Sir Al was right, all tests are necessary!!
$64M question:
Do we get a share of the cake??

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Independent reporting
https://www.independent.co.uk/news/uk/politics/coronavirus-rapid-testing-boris-johnson-tier-3-lockdown-b1760082.html

Local leaders have suggested the programme has helped to identify hundreds of asymptomatic cases.
Using rapid lateral flow tests – producing results in 30 minutes – the testing regime in the city has seen over 200,000 people being tested and contributed to a “substantial fall” in coronavirus cases, No 10 said.

Looks like the Innova LFT is producing the results that we all knew mass testing could provide!
This bodes well for all manufacturers of LFT tests!
Hopefully, we get some part of the tender awarded on Wednesday 25th Nov!

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