Member Info for tomvisual

AgentB, thanks for the bid documentation.
Points from Attachment 5.
1.Weighting is 90% based on price, 10% product packaging size
2. 5 potential suppliers can be selected (30%,30%,30%,10%,10%)
3.Priority 1 : saliva,nasal,throat
Priority 2 : Nasopharyngeal
More weighting appears to be attached to SALIVA.

https://health-family-contract-search.secure.force.com/servlet/servlet.FileDownload?retURL=%2Fapex%2FProSpend__CS_ContractPage%3FsfdcIFrameOrigin%3Dnull&file=00P4J00000AZLxSUAX

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Do we seem to be going back to saliva??

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From the curves in Sir Al presentations, I reckon these non-covid tests will be antigen tests.
PCR is expensive, slow and has a long tail characteristic response!
Seems to me Sir Al has the ear of the Govt.
Just got to see how much this translates to orders!
A major slice of £912M would be an excellent start!!

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Larsh, good find. Hanc ock wants test, test, test
"When in doubt get a test doesn't just refer to coronavirus, but refers to any illness that you might have."
"Why in Britain do we think it's acceptable to soldier on and go into work if you have flu symptoms or a runny nose, thus making your colleagues ill? I think that's something that is going to have to change."
"If you have, in future, flu-like symptoms, you should get a test for it and find out what's wrong with you, and if you need to stay at home to protect others then you should stay at home. We are peculiarly unusual and outliers in soldiering on and still going to work, and it kind of being the culture that as long as you can get out of bed you still should get into work. That should change."

WoW! Fast, Sensitive and Specific non-Covid tests? Sounds just what Sir Al mentioned in the RNS of 23/11/20.
This could be massive!! Non covid testing goes on and on.
LFT with rapidly programmed affirmer anyone???
Excellent!!!

See table in tge Telegraph for flu like symptoms diagnosis calling out for an affirmer test!!!
https://www.telegraph.co.uk/politics/2020/11/24/dont-go-work-runny-nose-says-matt-han****-reveals-flu-testing/

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For comparison, from
https://avacta.com/wp-content/uploads/2020/02/Avacta-Investor-Presentation-February-2020_v2.pdf

Slide 9,
With 12mg/kg of preCISION pro-doxorubicin 100% of the Acacta mice survived after 60 days!!
This is 6 times the dose of standard doxorubicin and no mice deaths!

Well this bodes well for our AVA6000 trials in 2021 Q1!!

Note, CISPR is another method for covid testing.
Seems like everything is linking up nicely!
DYOR!!

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The scientists noted that mice with cancer who received the treatment had double the life expectancy and their survival rate was 30 per cent higher compared to the control group. The scientists noted that mice with cancer who received the treatment had double the life expectancy and their survival rate was 30 per cent higher compared to the control group.

Can anyone remind me what Sir Al stated for our mice when undergoing the Avacta PreCision treatment??

Thanks Monkshood the dots are joining up again!!

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PL75, Deeks Twitter is interesting....
If Avacta meet the MHRA Desired Criterion, I argue you do not need the complementary PCR!

However, for me, the whole aim for mass testing was as per the Harvard discussion
https://m.youtube.com/watch?v=h7Sv_pS8MgQhttps://m.youtube.com/watch?v=h7Sv_pS8MgQ

and 'Test sensitivity is secondary to frequency and turnaround time for COVID-19 surveillance.'
https://www.medrxiv.org/content/10.1101/2020.06.22.20136309v3

It states that sensitivity of 50% is needed for mass testing! SPEED is the key, not sensitivity!!
Seems to me, there is no joined up thinking of what is required from the various test assays.
What Deeks is after is a faster test than PCR but equally as good as PCR.
As he is adviser to Govt, who am I to argue??
But no antigen test meets MHRA Guidelines Desired Criterion!
Perhaps until NOW!!
As I posted earlier, Sir Al must have set expectations. You sense that in Grant Shapps response to new LFT coming in January.
If Sir Al has an LFT that meets MHRA Guidelines Desired Criterion, he has the best of all worlds! That's why its the Holy Grail! Its the ultimate test. Its fast, sensitive and specific!!
From Boris yesterday the LFTs are filling a massive task! Boris therefore wants the best test!
If you tender and a lesser test may be used, would you be happy? Absolutely not!
If Sir Al has capacity to produce LFT at scale, then imagine for a moment ... could the full £912M tender be coming in Sir Al's direction???
Privided capacity is available, I would conclude the answer could be a definite YES!!!
Why would they want a lesser test with all the uncertainty that Deeks echoes out??
If I was Sir Al, I would engage Deeks ASAP!

I have said it 4 times tonight, What a difference a day makes!!

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Monkshood this was covered by Ophidian. See my post yesterday, 23/11/20 @ 15:30.

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Okehurst,
Please listen to Professor Deeks on R4 Today (24/11/20 @ 6:51) and
https://m.youtube.com/watch?v=h7Sv_pS8MgQhttps://m.youtube.com/watch?v=h7Sv_pS8MgQ

and 'Test sensitivity is secondary to frequency and turnaround time for COVID-19 surveillance.'
https://www.medrxiv.org/content/10.1101/2020.06.22.20136309v3

I think your assumption is correct!!
He is hitting the sweet spot!!
That's what leads me to conclude we meet MHRA Guidelines Desired Criterion!!

Tesr, test, test

If I am correct, it also signals to big Pharma the importance of affirmers!!!
Could this also be related to the non Covid related development that Sir Al referenced in the 23/11 RNS??
WoW, what a difference a day makes!!!

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Does Avacta have the ONLY Antigen test that meets MHRA Guidelines DESIRED CRITERION??
That's some ACE to have at the negotiation table!!!
Don't forget my post this morning on Professor Deeks comments about the limitations of the Innova LFT (listen to R4 Today, 23/11/20 @ 6:51).
If the Avacta LFT meets Desired Criterion, then no additional validatory PCR would be required!
This is exactly what is required.
This is exactly what the Government is waiting for!
This is what Grant Shapps was talking about!!
DOo Avacta have the Holy Grail of Antigen Testing??
I am going to say YES!!
Just needs clinical confirmation!!!
Excellent!!

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Diplomat, agreed. Better still Sir Al kniws everyone elses laboratory and clinical evaluation data in terms of Sensitivity and Specificity.

MHRA Guidelines
Acceptable Sens > 80%, Spec > 95%
Desired Sens > 97%, Spec > 99%

https://assets.publishing.service.gov.uk/government/uploads/system/uploads/attachment_data/file/895745/TPP_Point_of_Care_SARS-CoV-2_Detection_Tests.pdf

He has a good hand to play at the negotiation table!!
Come on Sir Al! The country needs you!!
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Sir Al stated in the RNS (23/11), that the diagnostic business unit has also made good progress on a number of other non-COVID-19 commercial opportunities. Is this a case in point??
Matt Han**** today laid out his aspirations to keep up mass-testing for mild illnesses like the common cold — even after coronavirus is defeated.
The 'soldiering on culture must end'!!
https://www.dailymail.co.uk/news/article-8981739/Matt-Han****-claims-Tier-Three-restrictions-lockdown-werent-tough-enough.html

Interesting development!!! Especially given the flexibility and the speed to manufacture of affimers!!!
What a difference a day makes!!

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Mafioso, can you validate OXFORD url link??

Scaredey_cat, a simple visual would be good enough. Affirmer present or absent?
Wayback Machine??
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What a difference a day makes ....
And to think tomorrow tender closes!

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Just a thought....
Could we tender for swab and saliva separately??
Thst is can we submit TWO bids.
Sir Al may have pulled a masterstroke and everyone was ****ging him off yesterday!!!!

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AgentB, CS, CO
From the tender documentation
https://www.gov.uk/government/publications/assessment-and-procurement-of-coronavirus-covid-19-tests/protocol-for-evaluation-of-rapid-diagnostic-assays-for-specific-sars-cov-2-antigens-lateral-flow-devices
Saliva samples from 15 different individuals will be spiked with SARS-CoV-2 virus stock (7.8x10^6 plaque forming units(pfu)/mL VIC/1/2020) and serially diluted in the same saliva sample to give dilutions of 10^5, 10^4, 10^3 and 10^2 pfu/mL.

300pfu/mL is well within ballpark by a factor of 2.6 in my book!!!!
Bingo!!

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"Requured standards" to be reached in New Year!
OMG! Knock me down with a feather!!
Looks like the Innova LFT may not be a slam dunk the derampers thought it was yesterday!
Is the stage set for an Entrance Stage Left for Avacta?
Lets see how the tender for £912M goes!
Don't forget this tender was delayed!
Topping up!!

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Professor Jon Deeks on R4 Today (24/11/20 @ 6:50) querying the Innova LFT!!
The Innova LFT was initially deployed to break chains of transmission. The latest proposals are looking at the negative results to say someone does not have covid so that they can be released from quarantine, students can go home and people can visit elderly on Care Homes. But when you look at the negative results in detail it all starts to break down. Innova guidance on the test says
"Negative results do not rule out infection and should not be used as the sole basis for decision making for management or contacts"
Deeks states the Innova negative results are not trustworthy!! WoW!!
Deeks states, So the risk is we will have large numbers of individuals travelling across the country who think they are negative when they are NOT!
LFT tests can only be positive when they have high viral loads (Sir Al's graphical chart).
Many people with covid do not get high viral loads to be called covid and even if the do they sre only going to be positive for one or two testing days.
The really important question is people who have lower levels of virus are they infectious?
There apparently are no studies that can be done very easy to ascertain that! Individuals may become infectious tomorrow or the day after as their viral loads increase, or they could be at the start of infection and their viral load could be rising very fast. So Deeks argues, the result from the Innova test, if it applies at all, can only be valid for the next 24 hours at the most as peoples viral loads have the potential to change strongly.
People testing negative in Liverpool have not be advised of this subtly. They have be told that 1/2
to 3/4 of people with covid have been detected by the Innova test. Your risk is still present, you test a lower risk but it is not NO risk!!

Hence it is wrong for them to visit granny!
It seems to imply that the rollout of Innova LFT testing ( if only Innova) is not a pancea for all ills. The Innova LFT test to me is not the silver bullet Boris thinks he has in the test armoury!!
A much better test is needed.
A test which is fast, sensitive and specific!!
Could this be the Avacta LFT?
The clinical trials will advise, as will details of the sensitivity and specificity of the Avacta LFT!
The Avacta LFT could be the holy grail that Boris seeks!!

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