RE: What is it worth?22 Apr 2026 10:32
This is what Chatgpt said when I asked about contract size;
"Historically, hVIVO plc has:
Run smaller HCTs (~100–200 participants) typically worth £5m–£15m
Reported its largest prior contracts in the ~£15m–£25m range (inferred from past disclosures and revenue scale)
This new trial is explicitly stated as:
“hVIVO's largest HCT to date”
So it must exceed that upper bound.
Several features push this into top-tier contract size:
~500 participants → very large for an HCT (typical = 50–200)
Phase III pivotal → highest regulatory importance (pricing premium)
First-in-world model (pertussis HCT) → bespoke development + assay work
Multi-year delivery (2026–2027 revenue)
Includes recruitment (FluCamp), quarantine, dosing, microbiology assays"
A rough industry model for HCTs:
Per participant economics (all-in):
👉 £30k – £70k per subject (includes screening, quarantine stay, dosing, monitoring, lab work)
For 500 participants:
Low case: 500 × £30k = £15m
High case: 500 × £70k = £35m
Now add:
Custom challenge model development
Advanced bacterial assays (Canary Wharf lab)
Regulatory-grade Phase III data requirements
👉 These typically add a premium uplift of ~20–40%
🎯 Estimated contract value
Putting it together:
👉 Likely range: £20m – £40m
👉 Most probable midpoint: ~£25m – £35m"