RE: Only 10 hours old22 Apr 2020 22:10
This study was carried out in 2014. Interesting outcomes and hopefully would mirror the results in this trial
American Journal of Respiratory and Critical Care Medicine
The Effect of Inhaled IFN-ß on Worsening of Asthma Symptoms Caused by Viral Infections. A Randomized Trial
Ratko Djukanovic, Tim Harrison, [...], and Phillip Monk
In summary, this study suggests for the first time that administration of IFN-ß by inhalation can enhance innate immunity both locally within the lungs and, to a lesser extent, systemically, thereby compensating for the IFN-ß deficiency that we have previously demonstrated ex vivo in the epithelium of patients with moderate-severe asthma (6). The possible beneficial clinical effect of treatment seen in patients with moderate-severe asthma that was associated with this enhancement suggests that this treatment may impact favorably on cold-induced asthma exacerbations. The trial was designed and powered on the basis of the entire mITT patient population; therefore, further adequately powered studies focusing on more difficult-to-treat people with asthma are now needed to test the hypothesis that IFN-ß is effective in this high-risk patient population.
Footnotes
Supported by Synairgen Research Limited, a University of Southampton spinout company.