Member Info for Scarabbeatle

I think if avct can use affirmers for there precision chemotherapy, and develope affirmers for virus zeka and c19.
Developing an affirmer for a bacterial cell infection( considering they have developed an affirmer for a cancer cell) wouldn't be a massive leap to make. If the company decided to fund that research arm then that would be a major breakthrough in the fight against antibiotic resistance. And the hospital superbugs. IF THAT IS THE WAY THE COMPANY GOES.

Affirmer coating over existing drugs

Along with the current c19 testing and potential neutraliseing therapy.
The Pre Cision treatment for me is exciting, the potential to use existing drugs at higher doses in a more controlled matter is somthing wonderful, potentially reducing the toxic side effects as well, again will have to go through the relative safety trials but so so much potential with this company.

They are looking for a partner to develop and go through approval validation. need some way/someone to manufacture. So at the moment way way behind avct.

It is the Uv light, causes free radicals in the protein structure of the virus basically denatures the rna, IMO nothing to do with temperature. Only when exposed for 30minutes, won't affect a infected person, or transition indoor.

Sunlight would kill the virus when on external surfaces, not whilst someone is infected. Not inside. Just to clarify

I have been here since about 40p, also in odx, I believe they are developing 4/5 tests not just antibody. Avct are well out on front on this LFD, and affirmer tech is a game changer

Major oversight on government behalf. Invected individual travels on a plane for 6 hrs, potentially invecting say 4 people minimum, who then get tested when entering UK airport. Those 4 people get tested right there and then. Pass the test as are not showing symptoms and are allowed to go about there every day lives believing they are not Infected. 7 days later when symptoms start they have already passed it on to people at work, there elderly relatives friends and family. I think this needs more thought of course IMO.

Seadog, the machine is ideal for a company, or a place gdr do somthing similar. But there is always human error, you would be asking security or air stewards to do a medical test. A simple poc test for the wide population would be ideal. Yes doesn't eliminate human error, but would take the responsibility away from airports, offices, business etc

Can't argue with that gaz, I said about testing once landed as the virus/symptoms may start on the plane inside the flight time, once that happens alot more people could become exposed, without knowing. Always edge on the side of caution, with transplants they are quarantining patients for 14 days with tests before they go into hospital, moving patients from hospital to Hospice or care homes, they test at the hospital and again once arriving at New digs. Etc

To be safe, they should test before, to see who is shedding the virus, then once landed test again to see any change, if the answer is yes then the whole plane quarantines for 14 days, with a test after 7. And another test at 14 before going out in general public. That way you reduce the risk and potentially contain any chance outbreaks coming into or leaving the country. But want do I know.

Is it worth mentioning care homes, they could be essential as they are the most at need, and have been recently neglected by the goverenment etc.

An increase in patients like that is very encouraging for proving the results. 600 patients is better than 100, plus COPD plus hospital arm, so around 800 ish for the efficiency/ saftey data, and significant improvements etc all good solid progress

Selling into the rise. Usualtrend. Upward movement so a bonus.

COPD being a Co morbidity the patients suffer from a low immune response anyway, any other virus can weaken the immune response further. That is why there are secondary bacterial infections also. But the treatment being a broad spectrum anti viral would benefit covid patients and COPD the same imo. as the mechanism on the immune response would operate similar if not the same.

More available and easier to produce than the current antibodies from people plasma. Could be a massive move, once saftey and efficency has been established

Well there will be plenty of numbers now, nation wide. Big step up here.

National expansion of home-based COVID-19 trial
Thu, 18th Jun 2020 07:00

RNS Number : 3008Q
Synairgen plc
18 June 2020

RNS REACH

Press release

Synairgen plc

('Synairgen' or the 'Company')



National expansion of Synairgen's home-based COVID-19 trial of inhaled SNG001





Southampton, UK - 18 June 2020: Synairgen plc (LSE: SNG), the respiratory drug discovery and development company, today announces the expansion of the placebo-controlled home setting clinical trial of SNG001 (inhaled formulation of interferon-beta-1a) in patients with COVID-19. The trial has been expanded beyond the Southampton area to include patients across the majority of the UK.



Patients in almost any part of the UK who have tested positive for coronavirus, and meet the additional eligibility criteria, can now participate in the home setting arm of Synairgen's COVID-19 trial. Daily video calls with a doctor or nurse will be conducted to supervise dosing with the study medication and for the assessment of trial endpoints. All trial supplies, including a pulse oximeter, thermometer, nebuliser and the trial drug, will be delivered directly to the patient, minimising the chance of spreading the virus.



Visits to the trial website for SNG001 have shown that the majority of eligible patients who have completed the online assessment have lived too far from Synairgen's virus testing laboratory in Southampton for entry into the trial. Synairgen has therefore amended the trial protocol to allow patients from elsewhere in the UK into the trial, provided they have a positive test result from another laboratory e.g. from an NHS testing facility. NHS COVID-19 testing facilities have seen a significant increase in capacity and turnaround times since the Test and Trace service was launched in May, making it now possible to get a test result within the timeframe required for entry into the home setting arm of Synairgen's COVID-19 trial.



The design of this home-based trial will not only test the effectiveness of SNG001 on patients identified earlier in the disease progression, but it will also generate valuable experience in the design and practical delivery of a model of remote care for at risk patients in this and future outbreaks.

Symptoms of COPD, is poor lung function, and a weakened immune response. The COPD trial is to show the benefits of added interferon beta, against COPD patients with a viral infection. Patients with COPD are the most vulnerable to viral infections that is why they are shielded at present. Also more then likely the patients which take up a large amount of beds during the annual flu /influenza (viral infection) season. And I would imagine as a consequence deaths related to Flu. So this treatment has the potential to save the NHS millions, if treatment can be from home. Can save lives and those beds can be used for other patients in an over crowded busy NHS, there is no longer a busy period our NHS is close to full capacity and collapse.

No mention of dosing as IMO it is the same dose as treats the patients lack of IFN Beta to stimulate the bodies own immune system, rather than the virus the patient has. C19 has been identified as having a weak outer casing which could be vulnerable to a strong immune response. Hoping that Sng 001 can give that boost to the immune system