Member Info for Scarabbeatle

Agree with all cells have a programmed cell death (when a cell recognises it is damaged, or comes to the end of its useful life often thought to be associated with the telomere.) , for me tho that is still being looked into and is still the holy grail in cellular biology, personally I don't think avcta have found that yet. Imo.

IMO, think of binding between molecules and cells like a lock and key, in affirmers instance being a easy to change skeleton key. The brains at Avcata can manipulate the key to fit different locks. Each affirmer has to be carefully tweeked to react with other binding sites, specific locks etc. The body isn't a sweeted key so one lock fits all. However with specific techniques Avcata are finding ways to unlock new exciting pathways previously not thought of.

Cracking info there, some of the language is difficult to digest. I have cut the first paragraph which I believe is important for treatment for covid 19. Not just the initial viral load, but the reduced vascular leakage, (Ards) and also the adenosine upreguate of cd73 anti imflammatory response, would this reduce the cytokine storm.
Type I interferons (interferon alpha and beta among others) are our first line of defence in infections (Levy et. al., 2003). As a counter measure to acute insults type I interferons enhance cell membrane and vascular integrity. Vascular leakage is an important feature in sepsis; severe respiratory viral infections, such as MERS, SARS and influenza; viral hemorrhagic fever, such as Ebola; systemic inflammatory response syndrome (SIRS) and ischemia-reperfusion injuries brought forth by major trauma or cardiovascular surgery. Type I interferons have the ability to up-regulate CD73, a molecule which yields anti-inflammatory adenosine (Jalkanen and Salmi, 2006). CD73 derived adenosine enhances endothelial barrier function and leads to the prevention of vascular leakage, the predominant pathophysiological event in acute organ injury (Kiss et. al., 2007), namely acute respiratory distress syndrome (ARDS), acute kidney injury (AKI) and multi-organ failure (MOF). Vascular leakage in acute lung injury (ARDS) allows plasma exudation into the alveolar space leading to potentially life-threatening hypoxaemia. Interferon beta-1a has been shown to reduce the impact of ARDS by reducing vascular leakage (Bellingan et. al., 2014).
My conclusion is that given at the right time this treatment could be a game changer. Which treats the majority of the c19 symptoms from early onset to when the infection leads to the point of going onto a ventilator. (Ards, cytokine storm late stage covid 19) all IMO of which I will be happily corrected. DYOR.

The Americans turned up lol.

IMO, you wouldn't need to increase the dose, if anything a reduction of the dose could be allowed for therefore decreasing the cost of the chemotherapy, as the dose doesn't need to travel through the body and be diluted to get to the tumour, it is targeted to that tumour/ tumour cells. Think of chemotherapy as a nuclear bomb, which effects the whole body, precision is like a drone strike, targeted. All IMO DYOR.

Well considering out of the two recognised treatments for c19, remdesvir only shows 5 % improvement in patients reducing time by 4 days. Compared to placebo.
Dexamethasone improves a third of the worst case patients on a ventilator.
So if positive results I can see it going past £2 easy. From there who knows.

The two companies deliver different products, on different timescales, avct sp took off a couple of months ago where as odx have been static for the same period. I can't see the point of this post.

Infected people who show no symptoms, may get through temperature checks, or you may be more contagious before temperature. Wearing surgical masks for any period of time even 5 minutes imo increases the amount of touching your face to either adjust the mask, or itch your nose etc. Alcohol gels are OK, but after using them 3/5 times then you have to wash your hands with soap as you can trap a film inbetween the gel applications as only 70% is alcohol which evaporates. The best way imo to remove the risk is to test test test. All other ppe will just give a false sense of security as non health care back ground there will be more human error etc.

My thought was that the affirmer platform was the patent. Which can be altered to suit many different scenarios. Ie virus etc.

The Sp has been volitile since people got spiked in March, the spike has happened on a couple more occasions. Lead to people being more cautious. There is plenty left in the share price but 50 to 60p would be nice pre results.

Having a proven broad spectrum anti-viral on the shelf in any medical facility will be a game changer. Fingers crossed for Interferon.

Na mate, it was the same 20 years ago when I pinned mice to a board to do tests. (in a lab) basic research models, shame I didn't continue, do com gas and air con now tho.

RK,
these mice are genetically engineered, and humanly dispatched. Very close to human models without using human subjects. See link just for confirmation on use of mice modelling https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3533445/

The share price is only what people veiw the companies worth and is willing to pay for it.
£10 would be great, and very possible with the pipline as it is atm. With more to come in the future. Royal Dutch shell was £25 last year. That is oil etc. This is game changing on so many levels, plus future covid outbreaks, 4 weeks for new affirmers to be developed, with more investment and better facilities that time surly could be reduced.

Again I don't see the relevance of the thread

All posts are peoples opinions, the links posted are factual, if someone is willing to discuss an opinion, then that is what any bb is about

Top man RK as always top post, agree this company has so much to offer.
TL slide 15 as well on pl75 link.

Tl my understanding, which if corrected will change, but the immunotherapy identifies the cells to the immune system. But the pre Cision releases in tumour cells.

Travel light. I think the pre Cision is an affirmer that coats an existing proven chemotherapy. The affirmer targets the cancer cell binds to it and releases the chemotherapy into that cell. Not the surrounding tissue. Therefore reducing side effects, and being alot more focused and targeted. If works it can be used for other cancers and chemotherapies. So you don't have to use as much chemo, lessen the side effects.

EGTP two different mechanisms involved with the affirmers for c19, and the affirmers for Pre Cision.
Affirmers for virus, bind to the virus and spike protein, which stops it entering the human cell. The virus replicates in the human cell which them causes the cell to rupture and release all the replicated virus.
The precision binds to the cancer cell to release the chemo into the cancer cell not the surrounding tissue. So I agree but thought I would highlight the different mechanisms.