Cracking info there, some of the language is difficult to digest. I have cut the first paragraph which I believe is important for treatment for covid 19. Not just the initial viral load, but the reduced vascular leakage, (Ards) and also the adenosine upreguate of cd73 anti imflammatory response, would this reduce the cytokine storm.
Type I interferons (interferon alpha and beta among others) are our first line of defence in infections (Levy et. al., 2003). As a counter measure to acute insults type I interferons enhance cell membrane and vascular integrity. Vascular leakage is an important feature in sepsis; severe respiratory viral infections, such as MERS, SARS and influenza; viral hemorrhagic fever, such as Ebola; systemic inflammatory response syndrome (SIRS) and ischemia-reperfusion injuries brought forth by major trauma or cardiovascular surgery. Type I interferons have the ability to up-regulate CD73, a molecule which yields anti-inflammatory adenosine (Jalkanen and Salmi, 2006). CD73 derived adenosine enhances endothelial barrier function and leads to the prevention of vascular leakage, the predominant pathophysiological event in acute organ injury (Kiss et. al., 2007), namely acute respiratory distress syndrome (ARDS), acute kidney injury (AKI) and multi-organ failure (MOF). Vascular leakage in acute lung injury (ARDS) allows plasma exudation into the alveolar space leading to potentially life-threatening hypoxaemia. Interferon beta-1a has been shown to reduce the impact of ARDS by reducing vascular leakage (Bellingan et. al., 2014).
My conclusion is that given at the right time this treatment could be a game changer. Which treats the majority of the c19 symptoms from early onset to when the infection leads to the point of going onto a ventilator. (Ards, cytokine storm late stage covid 19) all IMO of which I will be happily corrected. DYOR.
IMO, you wouldn't need to increase the dose, if anything a reduction of the dose could be allowed for therefore decreasing the cost of the chemotherapy, as the dose doesn't need to travel through the body and be diluted to get to the tumour, it is targeted to that tumour/ tumour cells. Think of chemotherapy as a nuclear bomb, which effects the whole body, precision is like a drone strike, targeted. All IMO DYOR.
Well considering out of the two recognised treatments for c19, remdesvir only shows 5 % improvement in patients reducing time by 4 days. Compared to placebo.
Dexamethasone improves a third of the worst case patients on a ventilator.
So if positive results I can see it going past £2 easy. From there who knows.
Infected people who show no symptoms, may get through temperature checks, or you may be more contagious before temperature. Wearing surgical masks for any period of time even 5 minutes imo increases the amount of touching your face to either adjust the mask, or itch your nose etc. Alcohol gels are OK, but after using them 3/5 times then you have to wash your hands with soap as you can trap a film inbetween the gel applications as only 70% is alcohol which evaporates. The best way imo to remove the risk is to test test test. All other ppe will just give a false sense of security as non health care back ground there will be more human error etc.
The Sp has been volitile since people got spiked in March, the spike has happened on a couple more occasions. Lead to people being more cautious. There is plenty left in the share price but 50 to 60p would be nice pre results.
these mice are genetically engineered, and humanly dispatched. Very close to human models without using human subjects. See link just for confirmation on use of mice modelling https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3533445/
Everyone who posts should be heard. Whether they are correct or not is another matter, if they are open to change their view or understand if they or other posters are correct. You don't want to get too carried away also don't want a good potential to be down trodden. Balanced discussions, lead to a better bb, which would enable new investors to make a balanced opinion. Therefore buy in ??
The share price is only what people veiw the companies worth and is willing to pay for it.
£10 would be great, and very possible with the pipline as it is atm. With more to come in the future. Royal Dutch shell was £25 last year. That is oil etc. This is game changing on so many levels, plus future covid outbreaks, 4 weeks for new affirmers to be developed, with more investment and better facilities that time surly could be reduced.
Travel light. I think the pre Cision is an affirmer that coats an existing proven chemotherapy. The affirmer targets the cancer cell binds to it and releases the chemotherapy into that cell. Not the surrounding tissue. Therefore reducing side effects, and being alot more focused and targeted. If works it can be used for other cancers and chemotherapies. So you don't have to use as much chemo, lessen the side effects.
EGTP two different mechanisms involved with the affirmers for c19, and the affirmers for Pre Cision.
Affirmers for virus, bind to the virus and spike protein, which stops it entering the human cell. The virus replicates in the human cell which them causes the cell to rupture and release all the replicated virus.
The precision binds to the cancer cell to release the chemo into the cancer cell not the surrounding tissue. So I agree but thought I would highlight the different mechanisms.
I think if avct can use affirmers for there precision chemotherapy, and develope affirmers for virus zeka and c19.
Developing an affirmer for a bacterial cell infection( considering they have developed an affirmer for a cancer cell) wouldn't be a massive leap to make. If the company decided to fund that research arm then that would be a major breakthrough in the fight against antibiotic resistance. And the hospital superbugs. IF THAT IS THE WAY THE COMPANY GOES.