Member Info for RichTheNewbie

FTSE being red has usually been good for biotech/COVID stocks....

Doesn't make any sense to me either.

It’s one of the big pluses from an investing POV if you believe they dumped it wrongly.
They obviously wanted it enough to buy but an inconclusive trial didn’t meet their criteria for carrying on.
However, if you look at that trial, it had two big flaws. They didn’t confirm virus presence in test patients and just went on symptoms. Also didn’t account for corticosteroids I believe. Which are commonly used in this kind of patients and may inhibit IFN-B.
This is a big part of why I was prepared to punt here originally.

Obviously.

The plot thickens. Not only are those last three AstraZeneca tweets about COPD but their one with a link for more detail mentions the ways they’re going to do it. First up:
“ Enhancing inhaled combination medicines: Inhaled medications are the backbone of care for COPD today. We’ve been developing the next generation of inhaled medicines, addressing unmet needs in exacerbation control and following the science behind all-cause mortality to better understand how we can aim to prevent early death from this devastating progressive disease.”

Not sure there’s a better description of SNG001.....

Nolupus you’re making yourself look like a total tit. I could respond in more detail again but it’s just a waste of time.
I’ll let you post some silly childish reply to this and ignore it.

Ghia - I never made big money from XEL. That was my example of a mistake in my early days. As I said, I was naive and sold out 5 or 10% down, or something like that, on a flash-dip to gather stops on the morning of good news. I used it as an example to help illustrate the dangers on AIM (especially when you're new). Didn't lose much (or anything) but missed out on massive gains at the time.

Woodstock - thank you.

Nolupus - I'm more than capable of considering the ups and downs of a share. In fact you, if you look back far enough, you'll find examples of me being the first one to advise about concerns of a share I was invested in, and that I was selling out because of it. XTR was a good example of this. I went to a presentation/meeting in London, expecting to hear things that encouraged me to buy more, instead I lost confidence in the management and their ability, and sold the lot, and told people so at the time. Got an absolute shedload of abuse at the time for that (and a few thank you's). Turns out, despite the abuse, I was right, and you'd it'd need to rise something silly like 3000% to get back to where it was then.

Just because I'm currently positive on this share, because there's a lot of reason to be, based on published information, it doesn't mean I only consider the upside. My position is a quarter of the size it was (or something like that) compared to when it was 6p and rising....precisely because I consider the upside and downside. That doesn't mean I'm any less confident. If anything I'm more confident. However the share price determines the risk/reward.

So I don't care if you disagree with me about everything Nolupus. Feel free. Just don't get upset, and start all the tedious jibes, if I disagree with what you're saying, or if I say disagree with advice you're giving that I think will have a good chance of losing people money.

Anyway. Fantastic result in the big game today. Come on you blues ;)

I didn't say I was a better investor than others. I said I back my own opinion over yours. You're the one making continual silly jibes about talking the talk not walking the walk. Fact is that is that's a rather good way to describe yourself.
If you were actually here to learn then you'd not continually mock people who disagree with you.

I listen when anyone posts something sensible.
Thankfully I'm easily able to ignore the people who clearly don't know what they talking about, like you.
I imagine you're just bitter, with the shares you bought at far higher prices, then the spread bets you put on, then the more spread bets you put on, whilst it continued to fall. As you said yourself you're over-exposed.
Then when it supposedly broke your 34p important support you were banging on about it heading down to 27p (of course it didn't and niave people were just relieve of their positions at the lows).
I know it pains you much that I don't value your opinion, but quite frankly, ignoring people like you is why I was buying this heavily at 6p, and why I didn't return until I could buy at 35p, why I ignored your calls about support being broken and told people I thought it would actually head upwards form there.

I can talk the talk because I walk the walk. Unlike you.

If you start having an intelligent conversation that'll be a first.

MassiveRay - Basically he doesn't like it when I correct him every time he posts stuff that doesn't make any sense ;)

Whilst I can’t approve of switching side...I’m kinda not surprised. Norwich were dire! I’ve watched every game of the new season and it’s been tough going for the most part!
Sky’s crowd noise is lamer than I expected. Need more of the passionate bits during incidents and dangerous build up.

Yes - which brings us neatly back to the original premise of SNG001. It should help people fight off viruses. To avoid exacerbations. Avoid going to hospital. Avoid being wrongly prescribed anti-biotics. Etc.
Viruses mutate, and new ones come along, so a broad-spectrum anti-viral, that's safe and easy to deliver, it's hard not to see as hot property.

There's also a good chance the virus will become an established seasonal virus like flu:
http://www.bio-itworld.com/2020/05/29/studies-suggest-covid-19-could-become-seasonal-virus-other-news.aspx

Currently, we're in the period where you'd expect a virus to be lowest, ie April to October roughly.

In which case, we may see the second wave November onwards, and probably depend on how long this lockdown continues, and how much it's been eradicated from general circulation.

Nolupus - they've pretty much told you what they're doing...."Strengthened balance sheet for potential partnering discussions with regards to the COVID-19, future pandemic preparedness, and the COPD opportunity" and "Manufacture of SNG001 drug product and other supply chain considerations".

Rather than "planning for phase III trials upon success".

They've also stated they're hoping to be producing millions of doses later in the year (all being well). If they were going to phase III trials that wouldn't be the case.

Nothing is certain but I think it's simply the case that they're still (as always) preparing for a partnership deal (and also now preparing for manufacture/distribution of a COVID treatment - with or without a partner).

It'd be quite irresponsible to infer success from a limited number. We don't know how many but it's obviously not going to be lots of people. They're just behaving professionally.

Nolupus: you can call me a conspiracy theorist if you like but I'm not sure there's any area of American government that Trump doesn't stick his little fat fingers into and push them into doing things they didn't want to (whether directly or indirectly) ;)

Governments can do exceptional things in exceptional times. Trump authorised remdesivir even though it didn't work.

And on top of that, there's all the previous safety data, from SNG's other trials using the same substance/method of delivery. And on top of that, there's the fact it's not a radical new drug, it's a naturally occurring protein, and already safely used via injection for other things.
Hence I'd be very surprised if they were forced to go down a phase III route. Although this government is totally incompetent so you never know ;) (however they want to rush everyone back to work so it'd align with their interests to rush it through)

My point is.....what is a phase III trial?
It's basically larger scale testing and comparing to the existing standard treatment.
There is no existing standard treatment to compare to and if they recruit large numbers into this trial then they've basically just done a phase III trial.
This is on top of the fact this is an exceptional time and governments / health agencies will move mountains to get treatments into production if they work.
You really think, if they've tested this in 400-600 people, and it's had a marked benefit, with no safety problems. That they'll delay things by saying they've got to do a bigger longer phase III trial. They'd get roasted for that in the media imo.