Member Info for RayPointer

Of course Lindy also has a mAb for gastric cancer - FG27. This has Avidimab added.
I think she would be looking for better results than that provided by bemarituzumab.
Maybe this was the mAb for which a deal was almost done before Redmile threw a pile of cash at Scancell.
At the 2020 AGM, she didn't actually mention a CT for FG27, only that is was being progressed

Yes, Ivy, I suppose its like updating the flu vaccine, but as Inan says you have a vaccination bottleneck, maybe year after year.

Thanks katnick

I just read the post without reading the title and I thought that reads very much like an Inan post and then I looked at the title:-)

Yes, Inan has summarised it much better than I could.

Then when Covidity is shown to work on the N protein, the world will want 7 billion doses, job done! Thank you Lindy :-)

https://www.youtube.com/watch?v=tbU3zdAgiX8

I suppose in this context "multi valent" may mean it is aimed at different known variants of the S protein i.e. playing catch-up.

Hi hyms

Thanks for pointing that out.
I wasn't quite sure whether the document I posted related to the vaccine that the UK government has ordered.
Do we know whether the new curevac vaccine is an update on their first vaccine i.e. it is taking into account known spike protein variants?
If this is the case then IMO it could be still lagging behind what Covidity may provide. It could be 1st gen+ but not really 2nd gen.
Your comments would be most welcome.

I've eaten some shocking chips in my time :-)

The next picture will be a row of elephants carrying copper concentrate to the refinery.
The concentrate will be in trunks of course.

Sorry I should say next year for SCIB1 data.

Quite possibly Wild.
I'm hoping for a double whammy for Immunobody this year with great data in both Covidity and SCIB1/Keytruda trials.
That would certainly make the world take notice.

Where Lindy's approach may prove to be superior is that she identifies specific epitopes (i.e portions of a protein) as the best to target and then Immmunobody in combination with Avidimab activates the T Cells that match those epitopes.

Because of Immunobody's dual presentation aspect the activated T Cells have high avidity (ability to stay attached to the target) and also strong clonal expansion (the T Cells splitting to produce identical copies).
It is this high avidity and strong clonal expansion that may turn out to be key to Covidity's success.

As far as I know mNRA vaccines are messages to instruct the body on how to produce a protein, so yes this applies to any protein including the N protein.

https://www.curevac.com/wp-content/uploads/2020/12/20201214-CureVac-HERALD-Clinical-Trial-Protocol-of-Phase-2b_3_CVnCoV.pdf

This description of a clinical trial mentions the N protein in connection with antibodies but there doesn't seem to be a mention of testing a T Cell response to the N protein.

Can I have what you're drinking?

As far as I know, it is possible to have multiple vaccines in 1 jab.
It seems to be a common approach when vaccinating children.

https://www.nhs.uk/conditions/vaccinations/6-in-1-infant-vaccine/

I haven't found a link for multiple vaccinations for adults.
I suppose the criterion must be that the individual vaccines do not interact with each other and the mild side effects you get from each vaccine do not combine to produce more serious cumulative side effects.

You can get a cardboard cut-out of Dolly Parton. Maybe a bit flat for Rat's taste though

https://www.celebrity-cutouts.co.uk/shop/celebrity-cutouts/pop-stars-cutouts/dolly-parton-white-dress-cardboard-cutout/?attribute_pa_cutouts=lifesize-cutout&gclid=Cj0KCQiAhP2BBhDdARIsAJEzXlFh04a-9gmCIpG4541KZRDAUPAN1TmMRrBLHaGguqUDLCXMSAm4MpEaAk0aEALw_wcB

So to summarise MrBigShot's analysis, the SP is either going to go up or down :-)

hyms

I don't know if you saw this when it was originally posted

https://www.nottingham.ac.uk/medicine/people/lindy.durrant

"Future Research
We have identified a common process that occurs in most cancer that can be recognised by the immune system. This would allow us to design a vaccine to stimulate an immune response which would recognise and kill early cancerous cells. This may have to be boosted yearly as for seasonal flu vaccines. It could be given to people at high risk of cancer or to adults over 60 which are the most common age group for this disease."

You cannot fault Lindy on the scale of her ambition.

It looks like 2 EU nations are taking matters into their own hands

https://www.theguardian.com/world/2021/mar/02/austria-and-denmark-to-work-with-israel-on-future-covid-jabs-saying-eu-too-slow

The PhD previously discussed for investigating administration of Covidity intradermally and/or by inhalation looks like it is aimed at vaccinating large populations of the poorer countries.
If CEPI were to support Covidity they would obviously want to accelerate that research.

https://www.findaphd.com/phds/project/development-of-an-intradermal-or-inhaled-dna-vaccine-for-covid-19-and-beyond/?p127093

The chip shop wasn't in Exeter by any chance?