Member Info for potnak

No conspiracy, you can predate webiste\blog posts. The website should then publish it on the selected date. The website isn't working as it should.

ay, definitely squeaky bum time over there. The news could go either way. Some LTH are at break-even after years being underwater. would ya sell? If I'd have bought sub 10p I'd be top slicing defo. I'm with others here. It doesn't feel right. happy for them to make money though. AIM needs newly rich investors.

My main bugbear with patents and it's not just SAR that do it, most do. It's sometimes really difficult to track down if they have a patent or not. It's fundamental to know this so you can make an informed judgment to invest. I do understand the issue though. If you expect the SP to go up on applying for a patent then you have to accept that the SP will go down when\if it's rejected. IMO this is why Sareum only RNS when a patent has been granted.

What I mean about the dates is that it was too early to know by then? Unless they already knew and had already proved it could be done. But if that, why the 9-month window? Is this filing just getting ahead of the game? Getting in the queue as it were and by the time it is assessed, the Chinese will know for sure if they have solved the issue.

Maybe Fadec will be able to find more. The optimist in me says this is for Aurora and they cracked solubility but the dates don't add up.

Warthog. IMO it isn't about technical knowledge. It is about your attitude to risk. I try to take anything I read on here with a pinch of salt. The question I ask myself is am I comfortable with losing my money here. I'm in for about 16k so not a lot compared to others but a sizable chunk that I could use elsewhere. On the whole, I am willing to lose it for the chance to be 10x today's SP or more. Effectively, we have 4 compounds and there is no way all of them will get to market. It just doesn't happen. Statistically, when compared to the bio market in general, SAR will be lucky to see one compound get to market. The biggest risk in SAR's pipeline is TYK2. I believe that the percentage of failures at pre clin and P1 is huge, well over 90%. This is why Tim and John are spending so much time on MTD and finalising pre-clinical, it is probably the biggest hurdle we have to get over. Luckily for us, SAR aren't in the getting drugs to market business. The business model is to on licence and if they can de risk it as much as possible the deal will be bigger. They told at the Presentation in Aug that they AIM to have 1 TKY2 if not both ready by the end of the year. They've got about 13 weeks to go. If not, I'll fetch my pitchfork and join you all.

Great, Warthog. You have DYOR. I'd say that is about right. I wouldn't use the term, "not going anywhere" because we know what the plan is and we have timescales but your assessment is good. It's not up to anyone on here to clarify anything. You should now decide what to do now.

Not the place to discuss this, Utar but to be fair. I don't get PYC either. I've traded PYC because it has wild swings but unless they get some big deals, not piddly little 140k deals, I don't see how the MC can be worth multiple millions, especially when any startup with some big computers can do the same thing. Same with VAL, good luck if you are making money over there but something isn't right.

I've blocked it. Makes for a much nicer board. Anyone wearing a tinfoil hat is also blocked. After the presentation in Aug, this board was really upbeat and looking forward. We haven't even reached the first milestone they gave us in that meeting but yet there are people expecting news. We can't change anything and if you are already invested. It's a risky investment with big potential. No amount of research is going to be able to put your mind at rest. Just step away from the board, stop looking at the intraday. I'm more relaxed about my investment than I ever have been.

I know, wasn't having a go :-) I've skimmed off about 50k into a standard managed stocks ISA over the last 18 months. That was all profit but I grew more and more disillusioned with AIM so looked for somewhere safer for it. Even with Covid, I'm 8% up on the investment. SAR is my only AIM hold now. I do have 5k of gambling money in case a bandwaggon comes along.

Wait, what? you used to trade over a million a year and the stock market is going to make you a fortune! I think yours and my definition of a fortune is a bit different :-). 300k would be life-changing for me and by definition, a fortune to me. I hope it comes true for you (and all of us).

SAR737 is a sideshow. We have no control, we don't need the money yet, no point even speculating about it. It will come when it comes. TYK2 on the other hand could be big. Covid is back (not that it ever went away) and the government is worried enough to be talking lockdown again. Treatments are going to be at the forefront of the battle. If we got Covid grant news in the next week or two, I the think there would be a frenzy of buying. As Thoth would say. We are right in the sweet spot.

Yeah, she's pretty confident but she does say the symptoms I'm having now might be a bit of cartilage that has broken off. Good luck with the hip. I know of at least 2 in my club, in their 70's who are still running after having new hips. Amazing what they can do now.

Not had a full diagnosis yet but had an Xray a couple of years ago after a mountain biking injury didn't heal properly and that showed "early degeneration of the joint". I'm showing classic signs. It's a private physio and she has contact with various orthopaedic surgeons so we're are trying to bypass the standard NHS process and get straight to the surgeon. I'm still running, relatively pain-free but being 50. How do you know what is old age and what is a treatable condition? :-). There are lots of papers showing TYK2 and Rheumatoid Arthritis but I haven't seen much for Osteoarthritis. Imagine how many millions of people whose quality of life could be made better by TYK2. It isn't just about saving lives.

Bit of a personal TYK2 post. I am 50 and I run quite a lot. Specifically fell, hill and mountain running. Anyway, I have developed some of Osteoarthritis in my ankle and some early signs of it in my knee. Been seeing a very good Physio who is entirely science based, no fancy ice baths and shockwave type stuff. She tells me, contrary to what people think, Osteoarthritis is a biological condition, not mechanical and she has been sharing some science papers\blogs with me. I saw a blog yesterday showing Cytokines IL-1, 8, 18, 6, 10 and 4! Ha ha. I wrote back and said I know all about interleukins and joked, If only there was a way to switch the bad ones off? She wrote back as said how do you know about this. I answered with, “it’s loooong story” :-)

Yes and with Sareum's retweets and a looming second wave, in respect of TYK2\Covid, it is very much game on. I'd expect an Investor Meet presentation once the grant is awarded. I hope Tim and John have prepared a good slide show to get people excited!

Are you trying to say the ICR don't know what they are doing? They are the experts in forging deals. I suggest you email ICR and tell them your plan.

f*** me this is so draining. You lot are annoyed that Sierra didn't mention SRA737 when there was no official news released saying they would. It like saying I'm gonna wear short's tomorrow, it's July, it should be hot and then moaning that you are p*ssed wet through because it's raining.

For me, It was pretty obvious that SRA737 wouldn't be in yesterdays presentation because we haven't had any official news to say anything otherwise. If it is obvious to me, why not to others?

Makesomecash - its number 3 and they have been up front about it. The fact that some here believe otherwise is neither here nor there. TKY2 news by the end of the year, Aurora flt3 by Jan 2021 and who knows for SAR737? Covid grant in October is next and judging by their retweets, this is very much still game on.

Yes, but it's a conference. Nobody releases price-sensitive news at a conference. Anything to do with getting SRA737 moving again is price sensitive. They will need to alert the market first. You never know. there may be an inbound alert. Fingers crossed. I may also, not know what i'm talking about, which is entirely possible :-)

I'm not sure we will get anything worthwhile about SRA737. The presentation looks to be based around momwhatever. If it was anything major such as Gilead taking a bigger role in 737 of external funding, there would have to be an RNS. Which we may get sight of at 11/12 this morning? If not, it could be another "we are pursuing non diluting funding, blah blah."