Member Info for potnak

Half the amount of shares were in issue back then through but still, as you say, the SP should reflect the SKIL platforms value.

Hi Fadec. Isn't MTD a requirement for all drugs? It's just one of those hurdles we have to get over or it can never be approved. I wonder if there is a precedent set for not reaching MTD?

Sounds like a nice short for you, Darien. I wonder how confident you really are?

Hi Fadec. My point is it doesn't matter. We are not scientists, we are investors. We hope we have picked the right company but there is no doubt we are in a hot sector with a hot molecule. I don't doubt that TYK2 could be worth multiple billions one day. I do have my reservations that Sareum will be around to see it though. That's why I favour RMMs risk analysis with discounts accounted for valuations . At the end of the day, if Pfizer and BMS have potential blockbuster TYK2, you can bet the likes of Gilead, J&J and other will want in on the action. Even heavily discounted for risk, it could be worth more than multiple of today's sp. And We're not even talking about 737 and flt3 yet. I really want the science to come good but I'm in no doubt that I will have sold out by the time it does.

Hi Fadec. What you say is all true or at least could be one version of what will happen. The clinics will decide which compounds will come out in top. The winning compound or compounds will be the ones that show efficacy, pure and simple. That doesn't mean there isn't a huge amount of money to be made along the way. Market sentiment will decide that. When you say you don't believe what companies say, I raise you Tim Mitchell. A scientist, CEO who had never ramped the science or John and his inventions, even though lots here wish he would. If he Says 'best in class' he believes it and that is good enough for me. Sareum are further behind the other TYK2 as development goes but that means we are further away from the binary win/lose decision too. The compounds won't be in sareum hands when they get to that point. I'm no expert in valuing companies and risk but the deals that Tim listed were actually made and there is no reason that it couldn't happen here. Its a bit about of a paradox. We say, its all about the science but really, it isn't about the the science at all. It's about what big Pharma is willing to pay to be in the game. And the price goes up with every hurdle jumped.

Completely agree, RMM. Though, I do think the statement that goes with the 10Q could be worded better. Not for SAR investors but for Sierra investors. The end result would be positive for us. Not sure if Tim had any control when the grant news came but 1 extra day if FOMO would have comfortably seen the SP over 3p.

Nice one, Sad. Hopefully a decent contract to see you through to SAR making retirement a reality.

29p plus divi vehicle. I'm in! Where do I sign?

Ratburn?

What about AWOO? Young guy, made his fortune on 88e. Said he was the most flamboyant trader on AIM.

Google says 2.09. Been bouncing around all day.

Google says 2.09. Been bouncing around all day.

Have a look for RMM's posts. He shows some real world working out, which IMO, is hard to ignore. But basically bidding starts at 20p.

Lol, wasn't finished. If the sp reaches 10p under its own steam the buyout price increases. Tim and the board are playing poker here and we are just about to be dealt our last card, hopefully, the 737 milestone. That would make us self sufficient for a bit. All bets are off at this point. Highest bidder wins.

Absolutely, Andy. I don't think we'd have any trouble greeting 2 or 300 millions for the lot but Tom, John and the shareholders know its worth at least double that. RMM's analysis the other week shows that with some creative accounting, £600 million could be written off as the purchasing company's value would increase by the same amount. Patents, pre clinical work and POC is the key here. It's a 10 bagger from here with a successful POC.

Now it's a bit quieter in here. It's noting for the newbies what they have invested in. SAR have two TYK2 inhibitors in development. SDC1801 and SDC1802. SDC1802 has been developed for cancer and we just got a worldwide patent granted 2 weeks ago. I'm not going to list the types of cancer that could be treated with 1802 or the market size, they are huge though. Although both TYK2 compounds could be used to treat Covid. Right now, all we are interested in is SDC1801. 1801 was tweaked to specifically target autoimmune diseases and it is designed to inhibit cytokines. Also, 1801 has been tested by the US Ministry of Defence for Lupus. Why is this important? The patients who get seriously ill with Covid usually show signs of cytokine storms, where their body overreacts to the foreign invader and we may be able to turn off these cytokines so the body can fight off the disease. Even more interesting, is the fact that Covid immune response is very similar to lupus. SDC1801 and SAR are right in the sweet spot for a potential covid treatment. How big is the market? Gilead has had over 3 billion in sales for Remdesivir, since April and it has only just been approved. It also doesn't work that well. It just reduces the time to recover. SO how much in sales could an actual treatment make? Pick a number between 1 and 10 and add 9 zero. Even if SDC1801 doesn't come good for Covid. At the very least, it fast tracks the compound in all other autoimmune indications, again the market size has 9 zeros. There is a reason the LTH's have held all this time. I have bet on a 150 to 1 shot and, just like Betfred, I can cash out early if I want. I'm still excited as hell. GLA

I'm tempted to put my 5k back in but going to resist, still got 2.9 mill shares. That's enough fie a life changing amount. Hopefully there will be and update and news on the Sierra milestone in the next few week. Sierra 10Q for due next week or the week after. We should find out if milestones are provisioned on the next quarter.

Warthog and others. Do you even read the RNS and presentations? The grant was for preclin and POC. If passes tox studies and looks safe then its on to clinics. SAR will need a partner for this any won't have a problem finding one. Can't believe you are still down on the company when they have done exactly what they said they would. Could have done with 1 more day of shenanigans but I took a little bit out. Maybe you should have too?

Yes, Luton. The traders and the newbs don't know what this means. The grant and the Covid research could fast track the compound in the other more lucrative indications. The bigger picture here is huge.

Matador, why were you expecting more? Tim said they applied for funds to finish preclinical work and get it ready for trials. If successful, we won't need another. It will be licensed. The excitement over the last few days has been great but the big prize is still to come. I couldn't be happier with how this has played out. I always say, we née the dumb money to come and they did.