Member Info for PL75

Anyone been to McDonalds for their breakfast and added some extra sauce? You know, the one next to B & Q and M & S - hint hint, letters, nudge nudge, wink wink, say no more...

Easily explainable - there was an ODX RNS today

Mine's a flat white

Illiterate trolling. Should be ignored

Phew. Please keep me informed

I'm left wondering where my Rumour thread went. You people aren't grateful enough to benefit from my presence, I'm getting back on my donkey back to twitterland

Awkward. He won't be happy with that copy and paste.

‘those who want to post innuendo and half truths - just go check on the timings’

Probably best not to mention timelines, they’re not a speciality. Ok, so we’ll all give you the benefit of the doubt in sharing things too early. So when you said 250p in ten days several months back, when exactly did you have in mind? Unfortunately it’s a combination of timing and absolute BS, the badly timed element is a bit irrelevant.

Genuinely comical. Yet, despite continually making a clown of yourself, you’re still sticking with the obnoxious air of superiority with the pathetically childish and utterly ridiculous guessing games. ‘Not been able to confirm it’. Yet the price is back where it was. What was it? Nothing? The return of Sujood?

Toys will start flying, it’s time to flaunt off stage left again…

Where have you been? Anywhere nice?

Oooh, just like Sesame Street. Is it the letters B and S?

The 18x was with a higher dose, 2mg Dox Vs 12mg AVA.

I agree with bitl on this one. The tweet said DE confirms activation. It doesn’t, it confirms that it’s safe for phase 1a to continue and the dose to be escalated. It’s good news, but it doesn’t confirm anything is working. To flip the argument that they might stop if it wasn’t working for ethical reasons, well why not stop if you apparently now know it works for ethical reasons? Just start whacking in everyone if you’ve a cancer cure in the bag….

They’ve probably seen some promising data, but at this stage that’s all it is, it’s quite the leap to say it works. Just let the trial play out, ramptastic tweets won’t change the lengthy and thorough process that’s needed. We’ll find out more as it progresses from the company, not from inferences and guesswork on twatter.

Thanks for posting and the reminder.

I noticed the following... 'Patients in Phase Ia will receive escalating doses of AVA6000 following a 3+3 design, commencing with a starting dose of 80mg/m2, once every 3 weeks (Q3W) starting on Cycle 1, Day 1 (C1D1), until disease progression, unacceptable toxicities, withdrawal from treatment for other reasons, reaching maximum lifetime cumulative exposure to doxorubicin (or other anthracyclines), or death, whichever occurs first'

'reaching maximum lifetime cumulative exposure to doxorubicin'. Do we know how this will be measured? Will it consider the cumulative toxic effect in the heart or is it just measured with a calculator i.e. as simple as the cumulative total of the doses given? If the latter, then that suggests that this trial won't be considering the potential to increase this limit. Due to the targetting nature of AVA, I'd hope this would be a possibility - via a separate trial? Perhaps it won't be needed, the mice results suggested a concentration of 3x in the tumour. If the cancer is taken care of before reaching the limit then there's no need to think about changing it :-)

Have already paid something that you guess wasn’t paid? Nice one

https://youtu.be/zjedLeVGcfE

‘It really is comical the depth your kind will go to’. Then a comment referring to ‘reasonable’ readers. Anyone ‘reasonable’ wouldn’t be such a repulsive vile obnoxious human. You deserve everything you get m’lord. I suggest you reflect on your own behaviour before trying to scold others for the reasonable mockery of someone so phenomenally full of it.

That was two doses

The first paragraph is not how it appears in the article. The reference to affimers in relation to a section (5.2) talking about antigen testing and BAMS. Nothing to do with Quidel.

https://www.bioz.com/articles/showDocs/?q=Life_Basel__2021_Oct_17_16d4&uq=limited%20supplied%20affimer&v=PMC8538964

Yes, we’re missing you Gaz xxx

You can keep weirdo eggy over there thanks

Exactly right zoom. Anyway, I’m amazed at how much discussion there is on the short. It’s a tiny percentage by a company that tend to get it wrong but have done ok. Who cares…. Blackrock have shorted Jupiter, in capitalisation terms you might find (I can’t be bothered to get the calculator out) that the net position of the two firms is technically long. It’s a shame that aim is a game as mapp told us and the short is accompanied by a collection of disruptive vermin

Good to hear you're still sleuthing Poirot, always appreciated your excellent research

Change your record, oh, you can't, it's there for everyone to laugh at. Anyway, no need to be so angry at the world, lose your paranoia, cheer up, try smiling, accept your many flaws and try and be a better person. Maybe stop posting utter BS on BBs too. Definitely change your choice of sauce. You're welcome.