Member Info for PJT12

Br3xiUK, my gut feeling now is that Putin will issue the command to go in, either full scale or by way of an incursion, within the next 48 hours now that his mate Xi-Ping's Beijing games are out of the way. Speculative, I know, but I certainly won't be buying again until that happens, either way.

It's "Drivel", Sangijuelas1.........not "Dribble". That's a whole different thing. You need to lighten-up, dude.

This from Andrew on Telegram. It appeared on Google today:

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8831911/

PubMed Central (PMC) (https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8831911/)

Cyclooxygenase 2 Effector Genes as Potential Inflammation-Related Biomarkers for Colorectal Cancer Circulating Tumor Cells Detection by Liquid Biopsy
Cyclooxygenase 2 (COX2) has been implicated in cancer development and metastasis. We have identified

Br3xiUK, I agree totally with you about Ukraine and President Putin's intentions, having changed my mind over recent days about the likelihood of an invasion. I would have disagreed with you a week ago but the highly knowledgeable Bob Seely MP pretty much sums up (Putin's?) my current thinking about why it is likely, imo. He cannot leave his troops just sitting there doing nothing once the exercises have ended because they need to remain sharp. I've also suggested that naive Putin apologists watch an excellent Channel 4 three-part documentary, "Putin, A Russian Spy Story" which can be found under the "News" category on their website. Here is a Bob Seely interview as to the "whys?"

https://www.bing.com/videos/search?q=bob+seely+mp&&view=detail&mid=F83DFBE3750E8CC6F4FEF83DFBE3750E8CC6F4FE&&FORM=VRDGAR&ru=%2Fvideos%2Fsearch%3Fq%3Dbob%2Bseely%2Bmp%26FORM%3DHDRSC3

So, yes, keep our powder dry, although a large degree of the invasion factor is already built into the markets.

I know a man who can..........courtesy of Andrew:

"Because it is several years ahead, has 55+ peer reviewed studies, will have FDA approval and first mover advantage, has been trialed in a number of large scale trials (2 x ovarian, 1 x MBC) etc. Also Angle have large amounts of cash to push this forwards and US institutional backers. Vortex just doesn't have the capital to spend and is less well backed.

"Clinical cancer imaging focuses on tumor growth rather than metastatic phenotypes. The microtubule-depolymerizing drug, Vinorelbine, reduced the metastatic phenotypes of microtentacles, reattachment and tumor cell clustering more than tumor cell viability. Treating mice with Vinorelbine for only 24 h had no significant effect on primary tumor survival, but median metastatic tumor survival was extended from 8 to 30 weeks. Microtentacle inhibition by Vinorelbine was also detectable within 1 h, using tumor cells isolated from blood samples. As few as 11 tumor cells were sufficient to yield 90% power to detect this 1 h Vinorelbine drug response, demonstrating feasibility with the small number of tumor cells available from patient biopsies. This study establishes a proof-of-concept that targeted microtubule disruption can selectively inhibit metastasis and reveals that existing FDA-approved therapies could have anti-metastatic actions that are currently overlooked when focusing exclusively on tumor growth." "Incorporating new microfluidic technologies that enable capture of live CTCs, like the ANGLE Parsortix [35] and the Vortex VTX-1 [47], now demonstrate that it is possible to conduct McTN analysis on live tumor cells isolated from blood samples and rapidly detect the reduction in McTNs caused by Vinorelbine (Fig. 7e, f)."

The following from the highly knowledgeable poster, Andrew Smith:
Interesting peer reviewed study out yesterday that used Parsortix (and Vortex):

https://breast-cancer-research.biomedcentral.com/articles/10.1186/s13058-022-01506-2

Never take advice from some anonymous bloke on a BB - me included. Been there, done it, paid for it.

Goinglarge, here’s just one example of why people cannot trust any comments that you post on here

On 21 Jan 2021 at 15:42 you wrote:
“I have been advised to look at Angle but having seen that the shares are up 50%, I may be a bit late to the party?”
At no point thereafter (the day of your initial AGL interest) did the SP fall far below the 79p that it was that day (75p was the lowest). However, just two months later on 5 May 2021 at 12:49, you claimed:

“I bought shares at 42p, 76p and £1:15. Yes I am a classic deramper!”

42p? Really? I am happy to be corrected but many elements of your posting history point to the accuser who prompted that "deramper" denial from you as having hit the nail on the head.

I could give several other examples if you'd like but I am pretty sure that others will have sussed you by now.

digitalman, those with relatively long memories will remember a similar scenario here previously.

I'm not in at present but visit this site out of interest every few weeks as a former holder who will very likely return. I have just watched the AS / Fiona interview with Paul Hill after noticing some laying into both on here, suggesting they were unprepared in a very poor presentation. Much as I have lost trust in what has effectively been AS's BS over the past few years, I think the aforementioned criticisms of both their performances in this presentation are totally unfair and most likely down to derampers. I spent over 30 years on-air interviewing people and would have asked exactly the same questions as Hill, something I throw in for the benefit of someone I saw criticising him as a stitch-up merchant. We already knew about the LFT and I saw / heard nothing in that interview that would have prompted me to sell here. AS/Fiona both came across to me as confident, realistic and knowledgeable. Avacta, for me, remains a definite "hold" with the oncology potential in mind. Sleepy Dave has called it right for me here through accepting that there will be future ups and downs but longer term patience will very likely pay off eventually. That said, please do drop any future fundraise comments, AS. Didn't you learn anything the first time around?!

Or "one" with two accounts?

Cheers, Miavoce. Still encouraging but rest assured that I'll go back and kick Michael in the goolies.........and do my own proper research next time ;-)

Hiring 39 people. Courtesy of Michael Gibson on Telegram:
https://uk.indeed.com/m/jobs?q=Angle+PLC&hl=en&from=ja&radius=25&alid=61f6b14413b4cb289699e223&tmtk=1fqtvncog3p0c003&utm_campaign=job_alerts&utm_medium=email&utm_source=jobseeker_emails&of=1&fr=t

The metaverse is a huge investment opportunity. Might DEV setup schools within it or have I misunderstood the model? If not, how might they try to integrate themselves within it?

123jez123 "Is there anyway as a collective of long-term holders we can get to get together to request Al does some sort of investor update. "
Honestly, Jez? IMO, the best thing that he can do at present is to 'keep it zipped' whilst concentrating on delivering anything by way of a positive and productive surprise. I think anything he was to say at present would be seen as yet more of the same IE Talking a good game but unable to deliver.

Apre, can you give us a few examples of the libel? Yes, there have been harsh comments directed towards the CEO but - honestly - his record ever since the leaked fund raise - deadlines, product targets and now this - leaves a lot to be desired. He has brought much of the criticism upon himself. Many of the "paying critics" today could be seen praising him previously; it comes with the job.

Zoom, I once worked for a guy who was educated at Cambridge but when it came to 'people skills', common sense or sincerity he fell far short of what you might have expected. I think people often mistake academic prowess for strength of character. They are clearly wrong in some instances and yet we keep on misplacing our hopes and expectations in them. The proverbial leopard offers a decent lesson, imo.

@digitalman "We'll never see these numbers again." We could take that either way!

On a more sensible note and as a LTH, how can anyone counter the point that this just looks like an antibody test whereas previously we were being told that Affimers were a cheaper and more flexible alternative to antibodies? Gotta be honest and say that AS looks like a Grade 1 waffler when I look back to this and then read today's RNS:
https://avacta.com/how-a-lateral-flow-rapid-test-works/

The bottom line is that most people are understanding, appreciative and sensible if you talk to them honestly and regularly IE Treat them with respect as adults. They will understand the hurdles if you keep them in the loop properly. I fear that AS lacks any real understanding of that, possibly because he is so over-protective towards his beloved Affimers. Someone at board level needs to have a quiet word.