Member Info for Malachi

Will the Basel work be included in the FDA submission? I am not sure of the rules. All the work that was for the FDA submission was being done in the USA. Put another way, do FDA submissions have to be based only on work carried out in the USA?
I think a drink is called for.

Parsortix proves that selling spades in a gold rush is a good idea. The Basel discovery that only CTC clusters lead to metastasis, if confirmed in humans, is a huge advance in oncology.

is the official organ of the Catholic Diocese of Hong Kong! How can PHE or their highly paid city representatives get this wrong? Not reassuring.

It sounds as if Dubrell has a head on his shoulders, something missing at HER for some time. We will see.....

Stokey12. Thanks for this information, which I had missed.

telephoneman. i have no wish to hide from history. Thank you for reminding me of my previous post. It was made before certification was achieved, and was valid at the time. I am happy that that matter is resolved. We indeed still do not know about maintenance costs nor down time for servicing. It may be, in the scheme of things, trivial or important, we do not know, and no doubt it will come to light once a unit has been run in real world conditions for a period of time. i suggest these are realistic questions for any investor.
You tell me the SP was rising at the time I made these comments (7th July 2018). So we have: 4th July 09.53 5th July .53p, 6th July .47p, 9th july 46p. 10th .45p, 11th .45p. As you say, you can't avoid history.
And for the record, I am not the reincarnation of Pomander.

Morgui, Desertwolfch. Thank your your comments. I don't like to pester the company with what I think are simple queries. Others: These were valid queries, why get upset? Why dismiss them, either answer them or if you have nothing constructive to say, as is the case here, just ignore them.

I am not clear on the issue of hydrogen storage. I understand that because of its small molecular size it tends to leak out of storage systems, and this is one reason to make it as close to the point of use as possible. OK, but I cannot see how there can be the equivalent of a petrol station for hydrogen because, as it was recently stated, a GH3 25tpd unit would require a total of ~1 acre of space, presumably with ancillary kit, storage for plastic etc,., and that is an unrealistic size. A typical petrol station in the Uk occupies much less space than 1 acre, and within built up areas, far less. However i can see this working for lorries where a depot might accommodate a GH3.
Second thought; how many operatives are needed for a GH3? Could the same number cope with more than one machine? Is it economical to have GH3s dotted around where they are needed, or might economies of scale dictate that some centrralisation is economically sensible?
Just wondering.....

Sharesport there was plenty about the repeated failures in various ZOX RNS announcements. I think they were using stainless steel at first, and then ceramics, but the problems continued as far as I recall. Anyway, it is reassuring to know that GH3 has been certified by external experts, and in no way do I wish to belittle PHE's performance.

I am not an expert, but was painfully wiped out in ZOX which used a high temperature rotary hearth furnace to recover zinc from furnace dust. The furnace repeatedly failed because of failure of the ceramic parts to withstand the combination of heat (~1200C, I think, similar to GH3), and corrosive gases. The performance of the ceramics might well be the achilles heel for the GH3 kit, and i hope very much that ceramics are more robust than a few years back. I read on this board not long ago that the GH3 ceramics are good up to 1500C, so fingers crossed. What a great day!

Not a runner IMHO. Perhaps this was suggested with tongue in cheek.

Approval by FDA will not now be until Q12019 at earliest. See RNS 25/10/18 "Whilst the enrolment of patients and analysis of results are conducted by independent cancer centres and outside the control of the Company, recent progress now suggests that both the clinical study and associated analytical studies will be completed by the end of Q1 CY 2019. " It is not uncommon for enrolment to take longer than expected, in fact IMHO it is more the rule.
FDA approval contingent upon these studies.

On reflection, I am not sure what weight the scientific community will place on the view of a QC. It is nice to have a positive opinion, but was this review carried out with the scientific rigour that would be expected if this were an opinion on a medical matter, such as efficacy of a drug.?. What I mean is; did he apply strict rules as to the quality of the data, such as population size, and the statistical power of the study, presence of contemporary controls, appropriateness of statistical analysis, etc, etc,.,. If this is the case then all is well, but otherwise this report is just a crowd pleaser. And before anyone wonders, yes I have been in SYM for years.

I understand that the main determinant of the rate of degradation in water is the oxygen concentration within water, although temperature is also relevent. The notorious BBC presentation of an academic from Portsmouth University represented his series of one, where the bag may well have been contaminated with oil, which would delay degradation. Bad science presented by the BBC which is refuted by a proper evaluation of the evidence.

Parsortix needed an American to help with commercialisation in USA. Sensible move, provided he has enough time to devote to it.

I think the big corporates in this field will be a) very very concerned at this major intrusion into their field, and b) wanting to bite Angles arm off to have a slice of this. It is a complete game changer in this field, and as RNS states, it opens the field to a much wider analysis of foetal abnornalities. Someone will worry about picking designer babies, no doubt, and there will certainly be ethical issues raised, but the positives are just enormous. Well done Angle, name your price..

"Over 75% of the required 400 subjects (200 metastatic breast cancer patients and 200 healthy volunteers of a similar age and demographic) have been enrolled into the study to date."

Enrolment was expected to be complete by end Oct, if I remember correctly so a > 3 month lag is disappointing but far from unusual in clinical studies.

The comment further down the RNS (below) is interesting: Parsortix isby far the most attractive system for isolating and examining CTs when compared to those presently approved by FDA, and approval will be a real game changer. I think the mkt reaction to this RNS is exaggerated by the general fragility of all markets at present.

"Meanwhile, extensive analytical studies continue at ANGLE's own laboratories and at the participating clinical centres. As a result of this work, new insights into the ParsortixTM system's rare cell capture and harvest capabilities have emerged that will further differentiate the Parsortix system in the market2.

This is a classic manifestation of a thoroughly corrupt market. why,oh why invest on AIM I ask myself - financial masochism is the only explanation thant springs to mind.

Justdeezerts. The Americans are obsessional about hygeine, and I think your acorn will grow a great deal more quickly than you might expect. And I think, as others have said, that d2p may be the driver for SYM rather than d2w.

So why , in the face of plenty of good news of orders is the SP tanking?