Seems...22 Oct 2018 16:54
To me (a mere layman!), that they have found a reason for the poor results in phase III, and that if corticosteroids are removed/controlled, then Traumakine will indeed work for ARDS patients? Could be good news for Faron, and indeed good news for ARDS patients too!! :) Awaiting the Japanese results with interest now...
"The controversy around administration of corticosteroids to ARDS patients has been a puzzling topic for decades where there has been an ongoing debate as to whether corticosteroids have any beneficial role, early, late or for more severe un-resolving cases. These new findings from the INTEREST study, where some patients were also given corticosteroids as part of their treatment, now suggest that we should control or exclude corticosteroids from future clinical research in ARDS patients. Corticosteroids have been shown to interfere with interferon-beta signalling(2) hence their use could block any beneficial effects of endogenous IFN-beta and may be particularly important when dosing with Traumakine. This brings fresh hope to ARDS patients as the study of Traumakine continues."