RE: Conundrum28 Apr 2025 10:50
You raise some good points in there Wyn. I'm a LTH but always like to read the bear case to check I'm comfortable staying long. In terms of your points raised, I think
1. The move to SGC is because it doesn't need to show improved efficacy, as there is no standard of care. To gain approval for other indications, based on safety profile alone, would have required much larger trials, beyond any budget Avacta currently have. AVA6000 vs Standard Dox appears to show some efficacy improvements, but it's not the route to pursue at this stage. SGC gives a route to a commercially viable and fda approved product.
2. Data could definitely be a point of contention. Limited availability for AVA6103, but early signs are VERY promising, which leads on to point 3...
3. My biggest worry, going back nearly 2 years when I started pumping money into this, was the risk of getting to commercial terms with a 3rd party. It's so fecking complicated and there are numerous ways to package this up. All against a backdrop of a dwindling cash runway. Avct has a potentially blockbuster platform here, worth multi-Bns, but at what point does that tip into the right risk/reward profile for BP? That is hopefully a question which gets addressed soon, but is the biggest risk here for me.
4. Risk of obsolescence is real, but I've not heard of anything, even from a promising ideas perspective that makes this near/mid-term risk. This will always be a risk in bio-tech, but given timelines and current horizon scanning I don't think it factors.
So, I don't think "we all agree BP is not interested presently". I am sure there is interest. Nobody here knows what has or hasn't been going on behind closed doors. Simon Bennett gets a lot of stick, but can't have been sitting there doing nothing all this time.
There are certainly some hurdles to jump and cash to find, for some of the reasons you have stated, but I remain confident this comes good.