Member Info for Doc.Daneeka

FTC7 who was it said opinions are like ars.eholes - everyone has one.

We do have a balanced debate, and many of us are frequently less excited than those who are in a near permanent state of exultation. But as Doc83 and gunto point out Vt And Ab4 are not part of this conversation. F.uck knows what they're doing here frankly

my take on the video Axe is that it's really nothing to do with Synairgen. I m,ean they're not culpable. They've been invited to participate in a wider promotional /informational prject by the BTS. It has no impact or relevane to anything thta is happening now or may be about to happen. I happy that they at l;east mantioned Covid - which is more than RM did last time out. You can be angry at lots that's going on or not going on - but this is a little fringey thing. It means nothing good or bad and should not be stressed too much either for good or bad. .

Get it to market did you say Doc ? You think RM needs to take the SNG cow to the Southampton farmers' market on Friday and see if he can swap it for some beans ? He'll get shouted at by the grown-ups when he returns to HQ and Donna will angrily throw the beans out of the window into the Synairgen garden. Next morning while the rest of the crew are slumbering deeply beneath their sailor blue duvets - little Richie climbs the huge beanstalk and someone else finishes the story because I've missed all the football today and I'm gonna watch the aussie fightback. The giant could be Covid - or Horby or A horrible great wicked PH(F)armer. And we'll have to work out how this even works at all as RM gave away the frikken SNG cow in exchange for some stupid beans. The beans could be SNG I suppose if Ratko was somehow the magic bean seller - but then what's he doing sneaking out and disguising himself from RM anyway. And what's Maud going to say when there's no milk...
Ok how about this. This works better. RM is the stranger on the road to the market with the magic SNG beans and Anthony Fauci is the idiot kid with the cow. They make the swap- yadayada - the bean stalk grows and Fauci climbs up and kills the Giant (Covid ) and brings back the golden egg laying hen which he airfreights to RM in Southampton in gratitude. The hen is allowed entry because the SNG beans have killed avian flu too.
Everyone except MrC gets a golden egg,. He gets the whole frikken hen, because of his huge holding but his stupid wife roasts it before it can drop a single oeuf d'or.

https://www.respiratoryfutures.org.uk/whats-new/respiratory-futures-and-the-british-thoracic-society-have-partnered-with-itn-business-to-produce-lungs-matter/

Programme released tomorrow - presumably the individual profiles feeding into the main edit. It's paid for by BTS & RS rather than editorial content but high quality nontheless

with 2 long established and proven... flu drugs

Given that Tamiflu and Baloxivir are already approved flu therapeutics ( Tamiflu since 1999 and Baloxivir since 2018) is it not possible that this study's entire aim is to assess existing flu drugs with Dexamethasone - given its success in Covid ?
Corticosteroids have been trialed unsuccessfully for Flu many times before and are proven to be dangerous to flu sufferers, but there is evidence that Dexa works better with Remdesevir in C-19, so maybe they're going after Dexa again as a combination therapy for Flu.

"In hospitalized patients with COVID-19 pneumonia receiving low-flow oxygen and dexamethasone, the addition of remdesivir was not associated with shorter hospitalization or lower in-hospital mortality but may have reduced the combined outcome of death and transfer to the intensive care unit."
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8853490/

And here's the prevailing evidence against Corticosteroids for Flu.
" Due to high morbidity and mortality, corticosteroids were seen as potential co-adjuvants in patients with influenza, especially those with the most severe forms. Animal studies suggested that the use of corticosteroids could ameliorate lung lesion in infected mice and improved survival induced by influenza A (H1N1pdm09) virus [32]. Due to this potential mechanism, the use of steroids has been seen as a potential alternative to stop disease progression and improve clinical outcomes.

The first multicentric observational study was published in 2011 under the European Society of Intensive Care Medicine H1N1 registry. It included 220 patients in ICUs around the globe. One of the most surprising findings was that the use of corticosteroids was as high as 60% and the use of corticosteroids was found not to be improving ICU mortality and was associated with increased risk of hospital-acquired pneumonia [33]. After this study, others were published showing the same results in patients with influenza A (H1N1pdm09) in Korea [34], France [35] and Canada [36] and with influenza A (H7N9) viral pneumonia in China [37]. After these studies, there was a good body of evidence against the routine use of steroids in patients with influenza. More recently, a large cohort study of critically ill patients admitted to ICUs in Spain found that the use of steroids was still prevalent and being prescribed in approximately one-third of the patients admitted to the 148 ICUs in the study. The relevance of this observational study is that it found that the use of corticosteroids was associated to an increased ICU mortality by a propensity score matching and competing risks analysis [38]. "
From
Corticosteroids for CAP, influenza and COVID-19: when, how and benefits or harm?
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7877325/

Obviously I may be off on completely the wrong tangent again, but it's a reasonable question to ask why Dexamethasone is on there ( with such strong evidence against CSs for flu )with 2 long established and proven

Ok then - so it turns out that we're not spoilt for choice Mani.. It's not us..... Oseltamivir, Baloxavir and Dexamethasone.

Balox is right

thanks Tommy/Jint - clears up what was not a helpful intervention on my part. Apologies.
Although always nice to see Peter Horby taking a boot in the goolies.

JInt yes I read that earlier. So a new trial for the platform that's been in place for 6 years. Question is what is the protocol ?
We'd have been eligible before of course is my point. Particularly when they added the Covid appendix to the protocol. Interferon beta 1a mentioned along with all sorts of junk to be considered or excluded..

https://www.remapcap.org/coronavirus

Andrewp - every time you produce your Gary Glitter/ Jimmy Saville analogy you summon the same horrible images. I can only surmise that you enjoy the pictures flickering behind your eyes as you write the words - but I for one do not - and find the constant repetition offensive. Unless you have some specific accusation of child abuse in regard to Vt to lay before the moderators - or HM Constabulary, for that matter, I desire you to desist. Suggesting "he only joined the board to contact Woodstock" is malicious and puerile. Many of us reported Woodstock, some of us several times, but the moderators for some inexplicable reason decided not to remove him. There is no connection that I've ever seen to link him with the object of your malice, unless it be some pitiful little attempt by one or other to support the grade school trolling of the other.
I have no interest in anything Viletrader says on this or any matter but I have even less interest in the evidence of your grubby little obsession.

https://www.remapcap.org/

https://clinicaltrials.gov/ct2/show/NCT02735707

I confess I'm confused by this. REMAP-CAP is not a new trial - it's core protocol was written in April 2016. And it's been studying pneumonia therapeutics ever since - with a Covid slant for the last 2 years (as many Covid patients finally succumb to Pneumonia). The funding I can see is for a continuation of this work.
Enlighten me please.

Ab4 has Italy at 50/1. Legend

all very good reasons to remain optimistic Doc.

Crazy board today - fund raising openly discussed for the first by some of the board's most positive members. You might be keen to pass over a few more quid, still chasing that average, but what exactly would the wider share buying public make of the proposition to do the same again - but better ? Why would anyone trust the company with more money and what would Polygon say ) And the Canada outpatient trial... SNG won't work in that space based on cost alone. HSD speaking the only sense. I'm a tedious one-note concerto on this as you all know. STRIVE is worth any of the supposed JVs or partnerships. It's worth 4 or 5 separate new ventures in COPD or Flu or whatever else they might be able to grab a hold of. NIH moves at warp speed when it needs to - our example is not comparable to some of the extraordinary FPD to EUA examples since it began. Ghia was also right yesterday that the Janssen thing is a strange act of altruism but nothing in it will benefit Synairgen in a timeframe that will stop the company losing control of its only potential supply of revenue. The company already knows SNG's targeted patient cohort and now just needs to confirm it. There are no other drugs in the Synairgen pipeline - but J&J have plenty that might benefit further down the track.
I'm not a doom-monger, the sun has just broken through here - but I'm waiting to hear just one thing and still think we have a fantastic chance.

Elon Musk by the way. Batsh.it crazy - evil most probably - but man does he ever get straight to it. Half of them sacked - top execs marched from the building with their stuff in cardboard boxes (which i thought only happened in Succession ) and now the remaining staff - who are ALL now back at their desks - have an ultimatum to work themselves to death every day - or leave. Click the link by 17.00 ET tomorrow or fu.ck off.

I'd like to see him take a look at Synairgen's set up. Just for fun. Maud would get one chance to make him a coffee - and if she doesn't have a bloody good reason why Arbor Day shade-grown coffee is not in her cupboard - she'll be floating in the dock with the rest of them. Prof SSH should escape the cull as he tears off his blue shirt and scoots across the corridor into the office marked Southampton Uni and dives under the desk.
He's a Bond villain and possibly the anti-christ but i bet he'd get SNG authorised in about 3 days.

https://www.bbc.co.uk/news/business-63648505

You've been consistent in this opinion Mani and much of the recent news supports it - as did RM in his last Proactive interview. STRIVE is our best option though IMO without doubt and the only reason we won't be on it is if they don't want us. None of us will mind whichever way it goes I guess as long as we get a trial. As I said a while back i think they have till the end of Jan to make a major announcement before the sp loses what's left of its value.

I'd even go as far as to say the STRIVE is the ONLY chance of us dosing patients this winter and fulfilling RM's confident statement at the AGM. Any JV would be announced well before the actual trial start date. They can't secret squirrel stuff like that and as we know it takes aeons for all that stuff to be put together.

I've nothing to say positive or negative about the prospects from here, as i just don't know - except that sudddenly we're galloping through November and the pages are falling from the calendar as fast as the leaves are leaving the trees. We're racing towards Christmas and the New Year without what we all hoped to hear by now. I'm still certain that if you had to choose a perfect in-patient trialist in the shifting-sands world of new variants - it would be SNG001. I expect Polygon were very keen that STRIVE would be the next step forwards for the drug and company, when the deep dive data was released, as many of us did. Just not sure why it hasn't already happened but still hopeful.
Anything else would be a disappointment to me - as the only way we get across the Covid line without NIH support is by surrendering a massive amount of equity to a partner. I'm not fussed for any of the rest of it - little involvements in useful but not material trials like the Southampton Uni/Janssen thing,or a huge flu trial that might take 2 or 3 years, and I just can't see the COPD nag coming wheezing over the horizon to rescue us.

I'm still all in for STRIVE and hope to god that's why Brooke refused to id our mystery man at the last US outing. V odd behaviour that.

Maybe Fruits but i doubt that or it would be targeted in a far more specific way. This trial's protocol is really wide open and Nirmatrelvir exclusions are already well recorded in the EUA. It's a very long list but most older vulnerable patients are still able to take it.
I think they want to almost use it as the control, and gain new data at the same time.

Can someone also clear up the 12000 patients thing which is in the protocol and which Mani quoted. Previous protocols - Like Activ include a total for all trialists rather than an individual recruitment number. They can't be trialing 12k per trialist can they ? And if this is the case what are the individual numbers they need. Presumbably somewhere around 1k again..