Member Info for Doc.Daneeka

Well said dunk, and with respect to Alpha who knows more than almost everyone on here. I lost faith in Ding when he spread such fear over the Chinese outbreak in late 22 early 23. Predicting economic meltdown - millions of deaths and almost promising a new variant would merge from the soup. Wrong on all counts as it transpired. He's a gifted worst case scenario merchant who did well in 2020 and has been sounding the klaxon ever since.

We can expect surges as the weather closes in again - and as Alpha says with diminishing protection - but as long as Omicron dominates, and the at risk take their vaxes - this winter will be nowhere near as dangerous as the last 3.

Re the question about when the new P2s will start. When they moved the goalposts from H2 to Winter - they were signalling that this year is unlikely and the probability shifted into the early part of next year. Unfortunate of course as lots of people were getting ill in a cold November last year - but if they're not ready they're not ready.

It's a Delta mutation Alkin - rather than a new variant. Happened several times before in the pandemic when an immuno-compromised patient is unable to shed the virus and it mutates, usually after a secondary infection with another variant.

Dangerous of course as this is likely the way all new VOCs start life - but in this case more likely to be a medical anomally that never leaves the single very sick patient or the room he/she is being treated in.

As things stand, with Omicron still reigning supreme almost 2 years after emerging in SA - any new variant would have to be more deadly AND more infectious to upset the general trend and throw the world back into turmoil. If it was going to happen the time for this would have been in the Chinese outbreak in the spring of 22 - when conditions were at their most propitious.

And the secondary part to this - is that the Synairgen sp is now only loosely connected to Covid. The only scenario in which SNG's sp might change fundamentally without new data would be if a new variant evaded all prior immunity & current vaccines, returning us to Year Zero, and making the SGO16 data suddenly relevant again.

Well spotted that man. I'm more than aware it's observational ( how could anyone not be aware that SNG is not involved when it's 21 months since we dosed anyone )

Looked back at Doc and Wigster's summary and RM said they were expecting a big push through the coming winter. They should have a few more than the 350 now but will surely take at least one more winter to complete (given they started dosing in Sept 22. )

350 should be plenty to spot anything of major interest though.

Thanks Gunto - it's not finished though is it ? Sure we had an update saying that they were hoping to complete recruitment in the winter of 23/24. Maybe someone in the chats around the AGM. It's become more important in my opinion as we realise how long it'll take to move to the multi viral P3. The possibility that Janssen or even AZ might increase their interest/involvement before the next set of company run trials complete. In any case it'll provide the next snippet of news and we'll discover exactly what tests they were running using Synairgen's machinery.

I heard "Winter" as the updated start date - which in terms of the calendar will be largely in 2024. I'm sure they'll start at least a couple of the trials before Christmas as they sounded close to being ready. They'll hope to fill them quickly as v small numbers. Universal has been running nerarly a year, needs 1000, and is clearly in need of a second winter. I'm surprised we haven't heard anything yet as the last update was that they already had good numbers and that was quite a few months ago.

With luck we can hope to see at least preliminary readouts from P2s and Universal in a year's time - assuming they all finish before winter ends.

What utter c.ock from G-Martin et al. A single Mers case in the usual Mers territory. None of the 100 contacts have symptoms and no previous outbreak (1 case does not equal an outbreak) has ever spread significantly beyond the ME. There is no vaccine for MERS because it's not worth the effort or expense to make. Daily Mail disaster reporting guff.

Neither is the rise remotedly related to Brand's Ifn study which is welcome enough but joins a very long list of supportive but not directly relevant studies.

This is just traders having their fun and pumpers trying to scare mere mortals into buying, suggesting the stock is about to take off - which of course it won't do until something more substantial is added to the data.

Well maybe Xv. The headline might scream Tripledemic - but it's the same story they write before every winter, and it's actually full of positive news. RSV vaxes from Pfizer, GSK and Sanofi with scores in the high 80%s and Mabs in widespread use for the first time ever against RSV. Accelerated programs to fill the gaps caused by lack of community immunity. Vaxes for Flu and Covid to be rolled out to the vulnerable. And if there's signs of a new Covid variant, it's still Omicron family and doesn't look any more dangerous than what we've has faced for the last 20 months or so.

So it's a mildly relevant piece - but mostly just a space filling exercise

"Thank you Bob Bloch " Don't start that again Aether - I've already disappeared down your HP Lovecraft black hole.

Agree with all you say on this Doc83. We've already demonstated our complete ineptitude on this share, ( some of the pre Magic Monday crowd admitting they didn't take anything out ofter the huge rise, and a large number of us adding more before Sprinter, and then another very large number selling in panic on the day itself. ) - that the chances of us getting a 7p to 5p gamble right are pretty low. Anything could pop the sp back up to 10p and then we'd be scrambling around again.

I'm still pi.ssed at how bad that RNS was and firmly believe that all of this bump and grind could and should be happening at a level that reflects much more accurately the company's achievements and inherent value. They screw.ed it up so bad that we plummeted to 11.5 (from memory) and even though the recovery into the mid 20s was swift, it was not sustained. We ought to be looking at 20s and 30s - but instead the sp lingers on the edge of the precipice.

Even those who put more in after Sprinter have been burned by the continued falls - and the solid announcements of the recent AGM made just a tiny little ripple that was quickly lost in the dark waters.

If we all truly believed that this will come good in the end we'd all be adding at these prices - but clearly most of us are not. Lower your average or compund your loss....

Agree on your last point and sure that's how it will be. The trials will be conducted in very few locations and they'd be remiss if they didn't admit every patient that fits the pre-screening criteria.

You were too generous to the Sprinter designers by the way. None of what happened was beyond their control - and definitely not the decision to chop the trial numbers. They did it partly because NIH said they could with the exclusion of the low dose arm - but mostly because they thought they'd sail through and replicate the P2 79% and wanted to save money. They knew most P3s are conducted with circa 1000 patients for very good reason.

GHia Jakman5 said that's how it will be - protocol or not - not only using UNIVERSAL data but in a known population.

"the intervention is not run on an randomised basis, against placebo product but on open label, where the trial data can be studied on the go - and because of the targets, such patients are already known to clinicians as they are regulars each virus season - ie they are repeat visitors. "

Gollumk - if what Ghia says about the protocol being essentially the same as the Asthma and COPD trials - with the trial managers waiting for their pre-identified old codgers to come wheezing through the door before they can start medicining them, that's an interesting insight as far as I'm concerned. It's neither positive nor negative if true.

And meanwhile the Spaceman is still floating happily in his parallel multiverse. " Let's see if Janssen close their China franchise deal (they said Q2) and their M&A team moves onto a mirror deal with Synairgen shortly..."

None of that presentation or comms crap matters an ounce. All that matters is the data they've generated and whether they can stand it up in the next set of trials and whether they can seethe whole shebang to a successful conclusion without diluting the share beyond the point wher we lose what little remains. My feeling is 40/60 on the negative side that we ever get anything back - but RM cosying up every month or a Comms Director posting superfluous extra stuff about women in science makes no difference to the reality of the situation.

I want to hear from them when the trials are about to start - or before if they have something else of material interest to add. Happy for 5-6 months of silence till then.

Professional has no interest in the company - and neither do you Org. I'm still invested and my posts come from that continued interest. And many of them have been critical when necessary. You profess to have sold out months ago and yet you still hang around - posting every single day in your little private kingdom of trolls and malevolents, and popping up here occasionally to see what trouble you can cause. You're more pathetic than Professional frankly - he at least claims to be trading SNG. But what are you doing here Org ? Seriously - with all the golf and holidays and "friends" After all this time - all your oh-so visible pain. All the failed attempts to connect with anyone here or there in a human way and you expect us to believe that your real life is so different and so fulfilled ?

Move on - or go back to the irrelevant other place and your virtual pals

Might be the fastest green bin ever. Stick to ADVFN Org - that's your spiritual home.

Re Professional - it's not a question of whether he's right or not, as many of us have made similar points over the last year and most of what he posts is self evident. It's more that he's a colossal world class intergalactic trumpian ar.sehole, who just won't leave us alone.

Gunto yes - it was announced in general terms in the placing RNS in October but this was the notification of trial name and protocol and imminent commencement.

Not sure what happened with the double spacing there. It was fine as it left my racket.

So - 2 weeks to a month between announcement and commencement - and they always put out an RNS. Would imagine they'll follow the same routine for all of the next trials, even though they're v small - as each protocol will be different. Unless they release all of the protocols together and then send a single RNS to say dosing has commenced across the board.

Comms regarding announcement of trials and FPD

SG016 (P2)

18th March 2020 "Synairgen to start trial of SNG001 in COVID-19 imminently"

31 March 2020 "commencement of dosing in trial of SNG001 in COVID-19 "

SG018 Sprinter

18th December 2020 "Synairgen to start trial of SNG001 in COVID-19 imminently "

13th January 2021 "commencement of dosing in its international Phase III study

ACTIV-2

25th January 2021 "Synairgen announces inclusion of its inhaled interferon beta treatment in US NIH ACTIV-2 trial

15th February 2021 " dosing has commenced with its inhaled interferon beta product in US Government-funded NIH

ACTIV-2 trial "

" They already have the interest of what we can assume is a major player, one who has requested additional data based on small trials in H2."

Morning Fruits Seems there's a new narrative developing - and we've seen it in a few posts since the AGM. That a big Pharma is waiting in the shadows and has specifically requested the new data. And will then move on the basis of the P2 mini trials instead of waiting for P3. Move to acquire the company presumably ?

I'll wait to see what happens but the idea that these trials will lead to any kind of major spike in the sp is highly optimistic. And as usual it's largely the product of confidential chats with company insiders - the kind of insider information that have been shown to be false so many times in the past. So I'm skeptical to say the least. RM did say we should bear in mind that BP might become iinvolved if the P2 studies started to show good data - but that's not really a smoking gun - not with his track record.

If there is someone out there puppeting RM and and the team I'd be very happy.

If a Big Pharma wants SNG before a P3 I'd be even happier, but the reality is that Synairgen will do what it has promised to do: complete these trials as quickly and competently as possible and then move to a large P3 to prove SNG for authorisation in multiple fields.

How they fund that P3 trial is the question - but unless the company is sold for a song after the P2 stage - a P3 will be necessary. What matters to all of us is that the SNG001 train finally pulls into its station and we're all able to get off - and it kind of doesn't really matter how that's achieved - but we mustn't follow false breadcrumb trails while we're waiting for journey's end.