Member Info for Doc.Daneeka

they come here because they're still ****ed off. lost more than they could afford to lose and can't leave it. maybe one or two have some ulterior motive but the vast majority are disgruntled sprinter shareholders who haven't got the guts to front up at the agm or even wait for rm in a dark alley - but come to claim their pound of flesh from anyone who is still a believer. td and co are good surrogate punchbags frankly - although as we all know - they all give much better than they receive and the trolls are invariably dispatched.

unfortunately doc of those 40 only 3 or 4 are of value. the rest comprise the drudgey thrust and counter thrust of men armed with plastic sabres slithering for a death grip in a toddlers paddling pool filled with **** and ****..

there's nothing going on apart from what we see. you can hypothesise it all you like but all anyone is doing at synairgen is trying to finish this ****show - and when it's over, hopefully with a modest win - they'll all be gone in an instant. maud standing there with her trolley and a freshly opened pack of bourbons as the car park empties and the landys disappear up the road.

until that modest win arrives spacman you need to eat it up like the rest of us.

Thanks for a fun day Spacman. Eventually one of these blue sky ideas of yours might hit the mark. Until that happens, and while we remain deep in the SNG trenches, your concert party turn is much appreciated.

https://www.youtube.com/watch?v=ufGJR2ViynY

And of course that's how you would change tack from 25 years of Ifns to a 2.0 CBD startup - by hiring a CFO who's dabbled in it a bit. He'll be able to set the trialing strategies and develop the formula. He's probably in the lab already

I was going to say it's a little early for me - but you go ahead Spacman. Roll yourself another Camberwell carrot and say something else. :)

Aether Org has had many alter-egos on this forum and elsewhere, but i can assure he is not Axe, nor is he MrC or Spacman or any of the others you occasionally unmask.

Org has a particular style of writing but lacks the depth or intellect of these 3 posters . He's been chased off here so many times and now dwells only in the shadowy world of ADVFN, surrounded and supported by an almost subhuman crew of ghouls and reptiles who drag themselves to the keyboard every 2 or 3 days to vomit their vacuous hate.

I think Axe might be on there, locked in endless pointless combat with Gunto - which is a shame as he was one of my favourite posters on this board before we struck the iceberg.

Let's move on from this my friend. The crows will continue to look for carrion on this board and elsewhere but we must not indulge them, and unless Org somehow recovers his equilibrium we need never mention his name again

Thanks gunto... and there has been no follow up announcement about this I guess. ?

" Being on a Barda funded trial obviously has a major impact on both our value to a partner and the share regardless of time to get a result which is covered by our own trials. "

my question was whether Synairgen offered SNG at this ARDS Therapeutics Pitch Event - which closed to entries on June 30th. If not then there's nothing supportive about it. Of course BARDA is still prepared to trial in our area - the question is whether Synairgen threw its hat in the ring. It seems to be studying exactly what Synairgen will investigate in its P2s - and from the protocol, SNG should be a prime candidate.

"As a hypothesis-generating study, this phase 2 trial is intended to gather as much data as possible on the ARDS patient population to better inform future clinical studies. In addition, an exploratory biomarker study will be included to identify patients who may benefit from specific host-targeted mechanisms of action and perhaps identify triggers for treatment. Specifically, this phase 2 trial is designed to collect relevant clinical and biological markers that can define subsets of patients with ARDS who may benefit from specific host-targeted therapeutics "

So its intentions are the same as UNIVERSAL - but with individual therapeutics. Moving in the same direction for sure but would be very good to be on this train.

Did Synairgen "pitch " SNG at this event ?

Hopefully we'll see the P2 protocols before Christmas - and maybe get an update on the UNIVERSAL bio-marker assessments we were promised. The first set of data from UNIVERSAL was not particularly helpful. Or at least it didn't contain any of the real juice that will inform the trial designs.

MC was a boastful scumbag before the fall - fooling nobody, and he's grown increasingly deranged since. Goodness knows how much he dropped on Synairgen but the more bilious his posts, the more you kinda hope he did have 500k shares at £2.

He's the man who turned a cool million into chump change.

It's not impatience Dudio. Or ignorance of how it works. They set a timetable - started the hare running and they were nowhere near ready. That's on them. They knew they had 300 datasets in hand at the time of the AGM and they hoped it would all be done in time to start before Christmas. And they were wrong. Twice.

Anyway - we must hope that the protocols are about to drop, that the locations are already lined up, that regulatory approval is well in hand and Maude remembered to turn the SNG fridge-freezer back on when she cleaned it out in Feb 22.

Nobody on this forum said the trials would start in H2, then Q4, then Winter. So maybe Synairgen - knowing that the UNIVERSAL data was nowhere near ready - should have been more careful with its predicted start dates.

Perhaps you should have emailed the company to remind them how tricky it was going to be and warn them that if the UNIVERSAL data was nowhere near ready, they should perhaps keep schtum until it was.

To lose one start window may be regarded as unfortunate, to lose 2 etc etc

Missed that extra s Fruits. Very good :)

I'm not talking about Matterhorn or Matml - both brilliant posters.

Morning Fruits - nothing to say as usual I see...

TP pay no attention. Only a couple of people on here think you're a 5th columnist - the rest of us appreciate your well written assessments. I'd only differ in your oft-repeated cry for better comms. I couldn't care less about the comms. They've got nothing to tell us at the moment and that'll do me.

Before the failure of Feb 22 - critics of any aspect of the company's performance were routinely swarmed and mostly driven away from the board by the Synairgen casuals. Most of those bullyboys disappeared with a puff of dust in the aftermath of the tragedy and they certainly hold no sway now. Fruits thinks we're all the same person. 7 or 8 of us. Td thinks we're part of a team :) In reality there is a clear distinction between genuine LTH critics or even skeptics and the traders, trolls and cut-purses that still haunt the board.

Happy to wait for the P2s but not to be lectured on how difficult these little trials are. We're not the ones who set 3 different start dates. If they weren't anywhere near designing the protocols they should have said so at the AGM. This company has had one drug for 25 years and if it was really not in a place to deliver on the first two timescales for the P2s it should not have been making them. In this context those who doubt whether the 3rd deadline is now set in stone are perfectly allowed to share those doubts. If they miss the current deadline - that's the 23/24 winter virus season gone. Remember this is the company that promised "with a high degree of certainty" that it would be in a trial LAST winter.

The point about the trials is that despite the small numbers required to fill them - the company will have to kiss an awful lot of frogs before finding those in the specific categories that will benefit. It might be only 1 in 50 or 1 in 100 of patients admitted for COPD exacerbations. UNIVERSAL should help clarify the percentages but they've all got to be tested very precisely before being admitted to the trial. So it's not necessarily gong to be as fast as we're hoping.

In relation to the delays.... might it be the case that if they'd swapped out a couple of the redundant 2021 hires in favour of more clinical expertise in this field ( and even AI ) they'd be moving a lot faster. ? You'd have to say that's unarguable.

ps Dunk .... surely Td was joking about writing those letters. ?

Like I say I'm not going to attempt to re-educate you on this Fruits. If the sum of your erudition is cutting and pasting ( as it usually is) it'd be a wasted effort. But for the board .... Less than 1000 deaths in 11 years - cases connected entirely and specificially to dromedaries and the people who herd them and drink their milk. And almost entirely in Saudi. It has left the shores a couple of times but was easily contained except for one large outbreak in South Korea. It does not transmit except in very close contact despite the apparent high fatality rate of 36% which is almost certainly an over estimate (says the WHO ) as this only counts confirmed cases and there aren't many labs in the Rub' al Khali. And recent changes in diagnostic tests on entrance to hospitals, isolation and masking have all reduced significantly the in-hospital transmission that charactterised it for most of its 11 years.

SNG may have performed well against it in a petri dish - but I'd say the odds of a) MERS getting loose and then b) SNG being called upon, are somewhere in the region of 4 billion to one.

It's niche niche is MERS - and thank the lord for that at least.

"Between 13 September 2022 to 12 August 2023, the Ministry of Health of KSA reported three additional cases of Middle East respiratory syndrome coronavirus (MERS-CoV), with two associated deaths. The cases were reported from Riyadh, Asser, and Makkah Al Mukarramah regions. Laboratory confirmation of the cases was performed by real-time polymerase chain reaction (RT-PCR).

All three cases were non-health-care workers, who presented with fever, cough, and shortness of breath, and had comorbidities. Of the three cases, two had a history of contact with dromedary camels and all three cases had a history of consumption of raw camel milk in the 14 days prior to the onset of symptoms. "

If we're bored - let's talk about something interesting like the Covid Inquiry

hope sng eventually takes the field against a range of viruses, but pretty certain mers is not ever going to be one of them. not going to rehe**** the stats again but i've looked into it deeply each time titania brings it here and it is now a really well controlled virus with almost all cases in saudi and the occasional outbreaks easily shut down. new covid protocols helped hospitals to diagnose and isolate cases and contacts and even if mortality is high, transmission is very difficult unless close personal contact with dromedaries ( ahem ) or consumption of dromedary milk. the high mortality rate comes from in-hospital transmission to health workers and patients on open wards and this is unlikely to happen now as it can be diagnosed on admission. this is all from memory - it's a nasty but really rare virus and at the moment no danger to the world.