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Anybody know much about this trial - in France using nebulised Interferon Beta 1b
Do you think this is what they are talking about ?
Not SNG - but either way - nebulised interferon
https://clinicaltrials.gov/ct2/show/NCT04356495?term=interferon&recrs=a&cond=Covid19&cntry=FR&draw=2&rank=5
Farons Traumakine is only on REMAP-CAP in Europe ( some french hospitals , but mostly UK , and so far not widely taken up due to steroid use )
USA Hibiscus trial yet to start for Faron , so don't think the French connection is Traumakine .
I think I remember a French lady scientist at the beginning of the pandemic working on neubulised Beta interferon 1b
Just for the record , Farons drug did not fail with the WHO , it was never used . What was used was Mercks subcutaneous injection of Interferon Beta1a . Faron never got a look in .
The upshot ( excuse the pun) is that subcutaneous IFN Beta1a was written off as a possible contender .
Intravenous delivery ( Faron ) - is now being trialed in REMAP-CAP ( with no steroid mixing as that is the drugs achilles heel ) . It never got much of a look in on REMAP until recently , as they were giving every patient steroids as standard care - hence voiding the patient as a Traumakine candidate .
But it is getting its own trial in the USA now , actually being compared directly against steroids , and in reverse of previous care , will be administered FIRST , before steroids .
Not as universally useable as SNG001 , but it still may play a valid part in the fight against Covid , and particularly ARDS , when the lungs get too full of fluid for a nebuliser to be effective .
https://twitter.com/lolmcshizz/status/1365016170634612740?s=20
Aha! Thanks PMJH for answering the May Day call! Very interesting indeed.
Thinking sideways for a bit.
Could it be possible that an early readout / data from our Home Trial has been released to relevant authorities (EMA, perhaps) and France have jumped the gun somewhat..... maybe?
The French can be impulsive ....
Try saying it with a Clouseau accent sounds passable Gallic.
But I think they would rather rub garlic in their eyes than save France with a very British product. Can’t see it.
It would be nice to get a tweet from synairgen in regards to what France have said, that's if its us
I won't waste any more space on Traumakine here , but Hew , yes the WHO would not disclose any data to Faron , but the WHO report conclusions were based solely on subcutaneous delivery ( of which there were I believe over 5000 doses given ) .
Consilium went on furlough about a week after they signed the contract with $NG due to the COVID situation.
Agreed @Doc, but that's why the conjecture of a route through EMA. Could they be slightly porous to their french friends?
https://twitter.com/MARYau_MCU_PH/status/1365023515146076164
The French Dr Aurelien Mary confirms it
Joey holey guacamole. Thinking.... need to digest this....
Is this post from 1855 naming sng 001 not correct then ?
Synairgen Research Ltd
Aurore.Moreau@p arexel.com; Estelle.Besson@pa rexel.com; Christelle.DeBortoli @parexel.com
Essai de phase III, randomisé, en double aveugle, contrôlé par placebo, visant à déterminer l’efficacité et la sécurité d’emploi du SNG001
inhalé pour le traitement des patients hospitalisés pour une forme modérée de la maladie à coronavirus 2019 (COVID-19)
https://video.lefigaro.fr/figaro/video/interferons-anticorps-monoclonaux-olivier-veran-fait-le-point-sur-les-traitements-contre-le-covid-19/
The original Le Figaro video from the press conference for those confident in French
It's of no surprise to me that our P3 is underway in France. It will be ongoing in many countries by now!
Doc - Stating that trials are well advanced could be referring to the program as a whole, SNG001 in the hospital setting is at the advanced stage now being in P3.
When vaccine trials have been reported on they've always talked about the trials as a program of P1 through P3, rather than individual trials.
It's frustrating tha we start the p3 just weeks before cases drop off a cliff. If we do an interim analysis on just the UK arm do you think we'll get an rns confirming p3 uk arm completion/ interim analysis in progress?
No chance Chris.
I know I sort of asked this in a roundabout way a few weeks ago, apologies for repeating.
HC, I'm struggling with your comment. How many doses can we produce before vaccines finish the job? Never enough, at least not for the next year.
I don't think they need PI's money anymore hence the lack of interviews recently by RM. They are fully funded for what they want to achieve and the path forward is now set in stone. We will only hear when an what they are required to tell us by the looks of it.
In the tweet of Dr Aurelien Mary there is also mention of CHUBordeaux - this is where Extavia is being trialled...
So 50/50 the French Ministers referring to SNG