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Exactly and it's not just AZ signing Phase 1 licencing deals recently. In the last year Eli Lilly paid Confo Therapeutics $40 million US Dollars in an upfront payment for its Phase 1 clinical trial candidate CFTX-1554. As part of the transaction Eli Lilly also agreed a total package of $590 million US Dollars in potential milestone payments and tiered royalties.....
Good luck, Brighty
2 lots of BED & ISAS gone through (15K and 74K) .. all 4 trades showing as sells which skews the picture
I was under the impression P1a / P1b was a fluid trial same as a 2a / 2b trial, as in if you you stop after P1a for any reason e.g. lack of funds or other reason then you cant restart a P1b at a later date and the only remaining option is a P2a.
Most trials are 1 then 2. Think the board originally chose 1a,1b because the value of deals would have been higher with good 1b data. This resulting 2a pivot is another reason I think a licence is inbound. No reason to do a 1b if you have the cash to go straight into 2.
Afternoon, quick question is the latest Edison report dated 03/04/24? Just want to clarify I’m reading the latest report
Hi Basil - it'd be interesting to know how many drugs developed by large pharma are able to skip P1b, not too many I suspect. I hope news of our intent is spreading through the pharma grapevine and we attract a major as a partner. That would put us firmly on the radar when it comes to 1802.
Any hint of good news and this will rise up quicker than a bad girls nighty
AstraZeneca has a track record of buying in to P1 clinical trials, especially once the topline data has been released. Another excellent example is Eccogene who were paid $185m upfront 5 months ago by AstraZeneca. This followed encouraging preliminary results from Eccogene's Phase I trial of ECC5004. In addition, Eccogene could receive up to an additional $1.825bn in future clinical, regulatory, and commercial milestones and tiered royalties on product sales. AZ could swoop in with a licencing deal for SDC-1801 if the preliminary results are good.
Easy multibag some like there 10% some invest and have a little patience
Watch this space it’s in demand and will get more and more in demand as we go higher
GLA
It's not just licencing deals that interest AZ at the P1 stage. e.g. TeneoTwo was acquired 18 months ago by AZ for its Phase I clinical-stage T-cell engager TNB-486. In summary, AZ paid $100m cash up front for TeneoTwo plus R&D-related milestone payments of up to $805m and additional contingent commercial-related milestone payments of up to $360m. i.e. A total of up to $1.265 billion. There is so much M&A activity these days with phase 1 candidates, both in on-licencing and takeover transactions. Sareum could be next.
Can only assume it's traders seeing SAR was in the top 5 risers of the day and jumping on board. Selling as soon as they made a couple of quid.
Long list of buys followed by almost equally long list of sells. Christ, are holders really that keen to get out on a 3.5p rise?
27.22p dont be fooled, this is in demand
Morning Bobbler - I had looked at Boehringer Ingelheim before but wrote them off as they're wholly privately owned so I presumed there would be no shares available to offer i.e. with a revenue of $9bn and no shares in circulation as such, how do we value circa 136000 shares in the company?
That all said, I'm puzzled by the following link - https://annualreport.boehringer-ingelheim.com/2023/letter/shareholder/index.html
If anyone can read or access it, good luck.
Regards.
I'm thinking that there are a few RF shares left and the mm's have let the shareprice rise this morning before resuming selling and giving the impression that we are running out of steam in order to encourage further selling. Don't be taken in by this. Not long to go though
The buys where bout 300k to good now only 50k so they have got a decent chunk of sellers already, let's see if any more interest at 29p if so it's the 30s today
Hoping that the profit takers don't kick this back down too much.
Didn't take much buying at all to get back to 29p on ask
Another key point to factor in is that we've not had a negative outcome in any of our research / trials to date.
For example:
* The June 2019 data showed 100% regression of tumours in lung cancer
* The Workman / Garrett March 2020 report showed that SRA 737 when synthesised with gemcitabine had extremely encouraging results
* We've also had the data from the UKRI project which showed that SDC-1801 was superior to the anti-inflammatory steroid dexamethasone and similar to baricitinib. The bull run up to that UKRI announcement in July 2001 saw the SAR share price climb in a few months x 6 from 1.5p (75p now) to over 9p (450p now). I am expecting a similar re-rate on positive P1a data. i.e. x 6 from here is over 150p. That's a x 15 for those that bought in to the 10p WRAP offer. It's possible and we know it's happened before.....
Good luck, Brighty
Something must be on the way, confirmation of RF being out maybe?
Looks like RF have cleared
Dummy sell 28.2
Was hoping to fill a last little gap, 10,000 @ 23p, doesn't look like I'll get chance now.
Try now, 26.5 has just cleared on L2.
Been trying to buy for the last 10minutes with Halifax
Nt for small purchases