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Agent B. I’ve just had lunch with a journalist from a national in this space. Believe me but there is zero sense or knowledge around this subject. In some ways it’s not surprising, albeit it’s just been one of the most important matters in our country’s recent history.
I can’t say who it is but I’ll put a version of the bundle together tomorrow and send. Fingers X it will be timely and gather some steam. I’ve offered a scoop on another matter once and if it’s run with.
I do actually know why, just thought they were useful additional points. Maybe not.
Great effort anyway, Heroic even.
Two things that should be included.
Cost - Molo head honcho said, "Our test is the best in da world" and more pertinent "It cost a quarter the price" GOV is paying INNOVA!
Why are UK taxpayers buying useless tests at an exorbitant price, from a pop-up shell company.
And - GOV revised required spec for qualifying tests for consideration. The change to anterior nasal requirement set us back months, whilst GOV is busying itself changing INNOVA test use case (from nasopharyngeal) rewriting instructions and approving home use for this substandard test.
Its Turkeys voting for xmas the way its being framed.
The entire focus should be on what makes AVCT better and questioning why it isn’t being used over Innova - not denegrating Innovas “low” Liverpool real-world numbers, which by extension allows LFDs in general to be slammed
well, unless this brings down the govt, I am not sure exactly how it helps. Is it not similar to Dom Cum expose of how BJ rates Handy? Apparently he can't be sacked now without showing up BJ for being equally useless? Now the safest of all Cabinet Ministers apparently.
Still, lets have million posts on this and make sure we don't clog up the board with stuff that is of no relevance....
I have sent versions of your letter to ALL the BBC Health Reporters, the Labour Shadow Health Minister and Labour's leader Kier Starmer .. I am sure something will happen... But I don't know what.
I have sent a letter to Mr Crispin Blunt, my MP. It is titled;
Scandal regarding the rapid lateral flow Covid-19 antigen tests that are the cornerstone of the UK’s mass testing programme.
I used your information and sources. In some small way, I hope it has some leverage/change of attitude. We will see ..
The justification for question 1 is the same justification for all LFD usage.
The Govt have explicitly stated the reason. It takes some who would be missed out if circulation. Repeated testing raises the nett S/S
Innova does a good job. Avacta is just better at it
Criticises Innovas numbers *proven* numbers in the field as rubbish is a total own goal. It opens the door to criticising LFD usage in general - as we can see is happening in the media
Its counterproductive - as I keep saying over and over
I wouldn’t even mention Avacta. Just mention there are British based developers with the capacity to manufacture in the U.K. The rest is obvious
Although I agree with all the anger and resentment about this, my main concern is stepping on AS's toes with hobnail boots (however well intentioned), I am sure that he is well aware of what's being going on (more so than us PI's)and is finding his own way through to a better outcome for Avacta! Beware of unintended consequences! Getting HMG's back up will not necessarily help us. Let's at least wait til Monday to see what AS has to say, we might be pleasantly surprised!
Tell them: firstname.lastname@example.org
UTTER CORRUPTION and almost complete destruction of the sovereign British testing industry to date.
Great points TEMPLAR, thanks for sharing
Late Sep/early October the UK Government told Avacta they no longer wanted a saliva test.
19 Oct ....UK Government 1st order of £138m Chinese Innova tests.
15 Dec...BRITISH MEDICAL JOURNAL confirms Chinese Innova test is utter rubbish stating that it detected " just 48.89% of covid-19 infections in asymptomatic people"
16 Dec onwards.....UK Government continues to order BILLIONS of pounds these PROVEN to be absolutely sh*t Chinese tests to date.
Don't forget to include Anne Robinson of she's still on watchdog and the ex policeman chap, raj?
Public enquiry 'in camera' incoming TEMPLAR starting next year, reporting 2032 and published, possibly, if/when there is ever another Labour government.
Some remarkably good ideas from posters including dealing with Andrew Neil.
All things Smith should be thinking about over his Yorkshire tea. You would think the Labour Party would be interested given the corruption and mistakes made.
Monday will be interesting to say the least even if most questions will be ignored.
Fantastic work Agent B et Al.
A very big THANKYOU.
One important question I would like to add.
The UK Governnent initially had saliva testing as the No1 preferred type of LFT test last year but then told AVCT in "late September/ early October" that they had changed their mind,even though AVCT said they had developed a successful Saliva test,and moved the saliva test from No1 to No4 out of 4, then started the IMMEDIATE award of the massive contracts to the sh*t Chinese tests sold by Innova.
Avacta Presentation and Q&A
51 mins 18 seconds
Q...Why did the saliva test fail ?
A..."It didn't fail. We took a decision not to progress the saliva test for several reasons" including "in late September/early October we got the saliva test working as well as the anterior nasal test working the UK Governmemt moved away from saliva testing " for various reasons, none of which included the first £138m Innova order just 2-3 weeks later on 19 Oct 2020.
Then, on 15 DEC 2020...The British Medical Journal reports that "Innova detects just 48.89% of covid-19 infections in asymptomatic people when compared with a polymerase chain reaction (PCR) test"
Even though our own highly respected BRITISH MEDICAL JOURNAL confirmed the Chinese Innova test was utterly useless they still went ahead and ordered BILLIONS OF POUNDS of completely useless tests in which "just 48.89% of covid-19 infections in asymptomatic people" were caught leading to half the UK population wandering around thinking they were OK when they were not leading to hundreds more deaths, thousands of hospitalisations and the continued shut down of the UK economy costing Billions of pounds.
This Government is corrupt and guilty of negligence on a massive scale and needs a FULL Public Enquiry into why they dropped all the UK LFT testing industry just days/weeks before they started spending BILLIONS on a Chinese test in which they KNEW was only 48.89% effective in picking up covid-19 infections in asymptomatic people then continued to order them even when the BRITISH MEDICAL JOURNAL confirmed they were utterly useless.
UK Government £3 billion Innova order history:
CORRUPTION AT THE HIGHEST LEVELS.
PEOPLE NEED TO GO TO JAIL.
For me this is out and out corruption and a Public Enquiry should be held into why the UK Government
These guys should know:
SARS-CoV-2 antigen testing: weighing the false positives against the costs of failing to control transmission
As should these folks:
False Negative Tests for SARS-CoV-2 Infection — Challenges and Implications
Dear All, I've already sent a version to Andrew Neil, but have reworked the sources for anyone wanting to use RNmyS ending (which I like very much.)
1 Expenditure on Innova tests: https://bidstats.uk/tenders/?q=lateral+flow+test
2 NHS rebranding of tests https://www.dailymail.co.uk/news/article-9127345/UK-coronavirus-Department-Health-rebranding-professional-use-kit-self-test.html
3 Gov rewrites test instructions (See question 21) https://www.england.nhs.uk/coronavirus/wp-content/uploads/sites/52/2020/12/C0964-lft-in-primary-care-faqs-v2-jan-2021.pdf
4 MHRA decision overridden https://www.whatdotheyknow.com/request/719170/response/1768848/attach/4/MHRA%20Letter%20DHSC%20COVID%2019%20Self%20Test%2022122020%20Redacted.pdf?cookie_passthrough=1
5 Performance of Innova Tests: https://www.bmj.com/content/371/bmj.m4469
6 Innova test fails to identify cases: https://www.england.nhs.uk/coronavirus/wp-content/uploads/sites/52/2020/12/C0964-lft-in-primary-care-faqs-v2-jan-2021.pdf
7 FDA recall of Innova tests: https://www.bmj.com/content/373/bmj.n1514
8 Heidelberg studies https://www.klinikum.uni-heidelberg.de/en/diagnostics-global-health
9 MHRA extends EUA for Innova tests: https://www.gov.uk/government/news/following-a-satisfactory-review-mhra-extends-authorisation-of-nhs-test-and-trace-lateral-flow-devices
10 Mologic to sue Government: https://www.telegraph.co.uk/business/2021/06/14/covid-test-maker-mologic-set-sue-government-stonewalling/
11 Novacyte legal action
12 Abingdon payment distpute
13Performance of Mologic tests: https://www.finddx.org/wp-content/uploads/2021/06/Mologic_Ag-Public-Report_v1.2-20210615.pdf
14 Performance of Avacta tests: https://avacta.com/wp-content/uploads/2021/06/Brochure-15 Avacta warning regarding Porton Down: (See page 55) https://avacta.com/wp-content/uploads/2021/05/Avacta-ARA-2020.pdf
Thanks Mr Adventurous, a couple of silly errors from me, I'll make some adjustments to my contribution and reshare "shortly"...
Abingdon Health not Abbingdon Health
sources for NCYT and ABDX are their RNSs
outed not ousted - but generally I would like to see a more objective and dispassionate argument than RNmyS makes - change "bending the rules" for example and, as you have done throughout, don't use "we" or "I" except in the direct plea that RNmyS puts at the end.
I think RNmyS's final para is excellent - it must be made absolutely crystal clear what action is expected, not just hoped-for, from the recipient. Perhaps add "...in the public eye" to the end of the sentence.
Sensitivity is to do with giving a positive if someone has it, i.e. is it able to detect very low levels of the virus.
Specificity is to do with whether the tests gives a negative even if there are lots of other similar molecules present the sample.
Very good AgentB. I have a few points for correction or clarification. Yes, I know I'm very critical but I hope you'll see it as positive criticism to improve your already excellent initiative!
I hope to see a final draft that we can all use to bombard the media, our MPs and other influencers with.
Bedford-based not Beford-based
Wetherby not Whetherby
Is this correct?
"In the Liverpool trials, Sir John Bell reviewed the Innova tests with the following results:
Specificity 99.68% (Specificity =correctly showing positive result for infected people)
Sensitivity 76.8%, reducing to 57.5% when used by non professionals (Sensitivity = correctly showing negative results for non-infected people)5 As a result, the tests would fail to identify up to half of active cases6 ."
I'm generally used to seeing 'Sensitivity & Specificity', not' Specificity & Sensitivity', so the way it's presented here throughout confuses me. Could someone with more knowledge (and logic!) than me comment on the veracity of the positive/false positive and negative/false negative description?)
"In medical diagnosis, test sensitivity is the ability of a test to correctly identify those with the disease (true positive rate), whereas test specificity is the ability of the test to correctly identify those without the disease (true negative rate)."
"This is because excellent CLINIC-based performance was not being reproduced at Porton Down's approval procedure WHICH involves the use of frozen Covid 19 samples (not permitted by the FDA). "
"2) How could the government justify extending the use of the Innova test when it is potentially failing to discover 40% of infections due to low specificity and not being used as intended" (not by professionals, not right up the nose)
Specificity or sensitivity? These are very confusing concepts!!!
"3) How could Govt & MHRA justify switch from Professional use Nasopharyngeal to Home use Anterior Nares with no supporting data? "
Swap this with question 2 and the "not being used as intended" of now-Q3 will be clear.
I've rejigged the final part, use or discard as you wish:
In bending the rules for Innova, the Government has failed to support the UK based diagnostics industry and appears to be holding up the development and validation of UK made lateral flow antigen tests. This can be evidenced by the actions of Mologic, a Beford-based diagnostics company, who have taken steps to launch legal proceedings against the Government for "stonewalling" the validation of their test 12. Furthermore, the government is also facing legal action from the Anglo-French company Novacyt for breaching their PCR testing contract with the DHSC (source) and are also in a pay dispute with the test manufacturer Abbingdon Health (source).
This is significant as our government claimed their top priority was and is the procurement of a sovereign test and supply chain, along with the support of the UK diagnostics industry. However, they are now being publicly ousted by the very industry they claimed to be supporting while continuing to ignore British innovation.
In the UK we have accurate lateral flow antigen tests. Both Mologic Ltd, alongside Whetherby-based Avacta Life Sciences have developed highly accurate, near-perfect tests which are far superior to the current NHS boxed, FDA banned, Innova test.
Mologic = Specificity 100%, Sensitivity 96.4%10
Avacta AffiDX = Specificity 99% and Sensitivity 100% 11
While these test numbers are impressive, the validation issues at Porton Down speak for themselves. As I noted, Mologic are now seeking legal action for stonewalling and Avacta have now warned their shareholders that Porton Down's procedures may affect the company's chances of winning any UK governmental contract 13.
This certainly is a scandal involving billions of UK taxpayer pounds. I implore you to look further into this story and give it the attention it deserves.