Member Info for BlackCat1963

I don't have a crystal ball or a chart. I don't make predictions. But for selfish reasons, I sincerely hope the SP stays low for the next two weeks so that I can get my inheritance in before it will go up .. massively on the run-up to 30th Sep and to infinity and beyond .. maybe to £5 and £10 if the news on cancer drug is +ve. It is getting exciting.

Would the NHS Trust not share the tender information with other NHS Trusts confidentially amongst themselves? If not, then the Government procurement process is crap...

Thanks Ndn71,
that makes some sense. So out of the 100+ suppliers, how many are UK based? and sorry to be a pain, but what is the price differential between the remaining UK suppliers?

What about the price comparison of the 100+ tests. Where does Avacta come in against the others? Pls. answer the question rather than insult.

BTW/ PR24. I am still in.. I have a paper loss (£50+K) I have not realised since I have not yet sold my shares. This has been a painful exercise for me as I have not done my AIM investing before. I was not expecting such a white knuckle ride. I did not want the SP to rise just yet as I am still waiting for some inheritance money to come through. I don't think that is such a crime to warrant the unnecessary abuse, but I will be very happy to get back to my average purchase price of £2.33

This looks great. I know Avacta's test is the best performance test on the market. But does anybody know the price differential between the 100+ suppliers? How does the Avacta test compare on price? Cheapest? mid-range or the most expensive? Some buyers are motivated by price and not performance. If Government have approved these tests, will any one of these tests do? I assume, that most NHS buyers would just go to the cheapest? Also, Avacta would need to be in a position to meet the demand. I assume they have the manufacturing capability to cope. I would love it we can get the SP up to £5 by the end of the month. I would be skipping round and round the room.

https://www.bbc.co.uk/news/magazine-35766627 Example a clinical trial that went drastically wrong. But, also when the drug did not work, it probably won't even make the news. Be patient. I bet it gets extended into next year.

I was just reminding everybody that it takes a long time for these research projects to come to fruition. No, I am very positive. I was waiting for a large sum of money (inheritance) to come through before I re-invest. I don't want it to go up just yet. Next month works best for me.

That's great Mookswood. How many years has it taken Avacta to get here? Did these proposals all work the first time? They got it right the first time and did not have to adapt and re-try again. Be patient.

You miss my point. You hardly ever get it right the first time. Be patient.

My dissertation was on the immobilisation of luciferase enzyme onto chitin (long-chain polymer of N-acetylglucosamine) a linker and then glass beads .. at Leeds University albeit 28ish yeats ago. I completed 10 or so immobilisations. None of the ****ers worked. It is an extremely difficult thing to get right. What's your experience? Trust me. Research often gets negative results. A negative result is still good data as it directs you to better more positive methods. This project will take time and you will have to be very patient.

Private Ryan
You wrote. It doesn’t take a degree in anything .. What??? So why does Avacta employ 3x Professors?? Research on new methodology often fails. It is very likely to take several attempts to make this new delivery system to work. This is not old wine in a new bottle. Just because there are no reports on any toxicity, does not mean that the bound drug worked. IThe drug won't behave in the same way as a free agent. The bound drug is very likely to have had no benefit. Until the data comes out, we won't know. But fingers crossed it will.

My take is the following; It won't be risk-free. It is still a punt. There may be toxicity issues with the substrate, the link and/or the drug itself when bound/tied/linked to the substrate. The drug will have to be around to do its thing. Will the drug still be as potent when attached? Will it still be able to degenerate so that it can be removed from the body. The lifespan of the drug in the body bound to the substrate may actually last longer. Hopefully, it will only be active in just the cancer cells only (i.e. behave like a silver bullet) and so not much drug will need to be used. This is the limitation of the free drug attacking the healthy cells away from the cancer. There are lots of known unknowns and more importantly unknown unknowns. They will have to play about with the concentrations to get it right. I would be very surprised they hit the sweet spot on the first attempt. Have heard about the Goldilocks and the 3 bears (not too hot, not too cold, not too lumpy, not too soft etc.)This is why they have these three professors? (Three Kings?) of cancer research who I assume will modify and play with the variable parameters to get the process to work. Whether this works or does not work first time also depends on how critical/sensitive and/or robust the process is. This is why this process is called research. It is for a reason. Some will variables have delicate parameters that they have to get right, while other variables may have quite large tolerances that even if these are different, the process is largely unaffected. I did a degree in biochemistry many many moons ago. If you think you can do better, then you should be applying to be on the research team. You can bet your last penny that they would have researched different scenarios, dry runs, or theoretical what ifs? At the end of the day, it is a punt, with the world's best minds on the case, the chances of success increase. The rewards will be super fantastic when it all comes together. That is why these clever people are on board to give it the best shot. I don't think you can give this an accurate % success rate. I assume that the % success rate figure comes from previous research data on other drug trials. Eddison made 1000s of inventions and most did not work. So mostly he was a failure. But 1 or 2 did work, including the electric light bulb. They have improved the light bulb many many times since then. Even though he failed many more times than he was successful, he is regarded as a success. Good Luck everybody and DOYR

Could somebody explain to me how a typical license deal works? Would Avacta take a % of profit, % or turn over, or a fixed fee? who pays for further development? Are the license payments upfront or at financial year-end, or both? Typically how long do they last? when will the license run out? 10 or 20 years? When it runs out? What is stop the licensing company from going alone? Or do they have to renegotiate a new license deal? What will stop other companies from copying the technology? I am thinking of Chinese companies. More importantly, how much will the whole thing be woth to Avacta? Is the license exclusive, or could other companies come in and use the same technology? Sorry, for asking??

PS Blackcat 63, Are you a fellow makem?
I don't think so .. who is Makem?
No novice Investor .. I did a degree in Biochemistry at Leeds 1982 to 1985, long before Avacta was even born. But I understand and recognise AND I REALLY BELIEVE that this company will be massive... but more likely to be taken over.
I hope it remains a UK company, but selling globally..

I am down £50K; against an average of £2.33 and this paper loss is really hurting me.
I am confident in the IP, the management and the long LFT market. Avacta LFT is the best on the market and I am confident it will sell in huge numbers .. so much so that I just bought some more £2K .. If I had more than £2K to invest.. then I would.

If the antibody level declines in people by 50% over 6-10 weeks, then we will have to mass vaccinate again. However, if these people catch Covid and the population buildup an immunity .. herd immunity? which is what I think is the hidden agenda of HMG, so that they don't have to revaccinate. IMHO, this is real reason why they are opening up .. and relaxing the rules so that people will be infected. It's part of the plan. The absolutely great news is that hospitalisations are now decreasing... FANTASTIC I cant see Covid testing being a big thing. The Chinese tests are crap and you might as well **** the wind.. The Government missed a great opportunity by blanking the AVacta's test. It would have saved a serious slice of money, lives and even lowered the curve of infection. I hope this tale of missed opportunities gets told and not lost in the 'fog of war' of words.

I hope they are VERY accurate .. because it might be very difficult and expensive to get the backup from a foreign hospital or the doctors onboard may/may not have the ventilators, PPP etc. The cost of the test is immaterial. The cost of catching it and/or passing it on is significantly more expensive.

I understand that it is illegal to shout FIRE FIRE FIRE in a theatre for that very reason. Although unethical, my guess is that it is not illegal to spread lies and unwarranted fear messages onto these shareholder platforms?? But it should be.

Is this not competition? Surely, we don't have the world exclusive rights to affirmer technology? Or do we? Please can somebody confirm?

I have got a reply!!! ; it says Thank you Ed, we are asking questions of the MHRA.

I understand that Justin Madders is the Labour MP for Ellesmere Port and Neston, and has been an MP continuously since 7 May 2015. He currently undertakes the role of Shadow Minister (Health and Social Care). Hopefully, it will shake the Government into action.

Regards