Morning all !26 Feb 2019 10:35
Crumbs.. Thanks for posting the research article yesterday .. Fascinating reading .. Although some of it is top level (a level above my understanding) I found the gist interesting particularly regarding safety and Reumatoid arthritis ..
This paragraph particularly ..
"The anti-tumour immunity was similar in HLA-DP4 and HLA-DR4 mice suggesting both alleles can equally present the citrullinated epitopes on tumours. Indeed, a single immunisation with the combination of citrullinated vimentin and enolase peptides induced significant anti-tumour immunity even 14 days after tumours were established. To show that these anti-tumour responses were not restricted to B16 melanoma, similar results were also obtained against the HLA-DP4 expressing Lewis lung carcinoma line, LLC/2. Immunised mice demonstrating strong tumour rejection showed no evidence of toxicity suggesting healthy cells do not present these modified epitopes. Indeed, it has been shown that RA cannot be induced by T cells alone but requires joint erosion, antibody responses and inflammation. This is borne out by studies where no autoimmune symptoms were observed with T cells alone, even in HLA-DR4 transgenic mice which are susceptible to RA."
I can imagine it takes a lot of time arranging these experiments to gather the required information ..
There was a concern that moditope could cause worsening of diseases that produce 'stressed' cells but it looks like that targeting citrullination caused by autophagy in cancer does not go on to cause any of these issues in conditions such as RA or indeed cause RA in patients that don't have it?
Any thoughts anyone else ? If I'm wrong I'd like to know ..
Take care all and thanks again Crumbs...
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