Member Info for Vander

BTW Mahan Air (Iran’s second largest airline) have been accused of ferrying military equipment and personnel from Tehran to Syria and other ME war zones. Germany have revoked their licence recently. Presumably WSG would not have to deal with this sort of security?

I am only asking a question....geez I am glad that all the internal stakeholders have been consulted and agreed so nicely

Humanbait and Etin I do not know much about the internal complex politics of Iran and would welcome informed opinion from those who do. However I know that the moderates who have signed off on our contract have different sensibilities and agenda to the hardline IRGC who will have a powerful say- possibly on regime change not just airport security

I agree USA should look v favourably on uk company What about the Iranian revolutionary guard - have they cleared it? It would be unpleasant if one of our guards found a cache of guns and said ‘did you pack these yourselves?’

Pacira make depofoam, a liposome nanoparticle- that’s it. One billion usd mcap I think Btw anand subramoury ( VP new product development medimmune USA) is excited re silica nanoparticles (c dots) he described it as his top moment of 2018 (see Dec 6th tweet) I hope their other msn will also be a top moment- 2019

The African MOU would be a massive plus as it would break the cycle of non delivery and the market may pay more credence to PFs inferences At the AGM did PF seem different in any way to suggest that this time things might be different??? Did he seem more excited or say things like- ‘ no really i’m Not bullshitting you this time. They really are going to fuuuuucin sign’

I am v positive re Africa Less so re Iran can I ask re progress on expansion of Tehran’s IKIA are? Presumably the upgrade of security be part of an overall upgrade plan? A delay in securing bank loans for the new terminal will be ameliorated by the SPV In 2004- the opening of the airport was shut down by the IRGC due to choice of foreign airport security (TAV)- the last thing they need is a foreign company poking their nose in, charging gov taxes and monitoring their transport of guns etc Sorry if this has all been discussed before- I am snowed in and so have idle questions

Yep. Initially they are focusing on dna delivery because of the spikes I hope the spikes work for mRNA also- I see more potential there- easier to get into the cytosol than the nucleus I imagine MSN’s are deceptively simple but how they interact with the biological milieu for each modality is not. They will have to test the physicochemical properties In a painstaking trial and error way It would help to have more patents from chengzhong yu and AIBN in the pipeline. Nuvec needs a material science dept as well as multiple clinical depts

John- from a drug development point of view- we are still at an early stage. As long as they are safe, because of nuvecs versatility, medimmune could test multiple types of products. We will use the UoA data to attract other partners (dna and subunit vaccines) but there are potentially Many other immuno- oncology partners I can see a lot of scientific potential- but not sure how you value it. The medimmune tie up provides an endorsement from one of the world largest biotech. This will grow over many years imho, as long as we diversify the products it is used in and make good choices early on

Thanks

Sorry I sent a post before seeing your reply They initially sent a bio now programme with the AZ chair not mentioned (see medi Wales) - otherwise same presenters and venue- different date 8 th Jan Not sure if the omission of the AZ chair was deliberate initially? N4p did not bother tweeting that programme but made a point of sending the second pne

Btw to be accurate there are 3 other presenters and the AZ representative is chairing. Also there will be a focus on manufacturing to CMC standards as this is Allan Hey’s area of interest, although the 9 month data and specifics of nuvec point of difference will come up. Alderley park is AZ’s largest r&d faciliy and their global hq for cancer research- is that correct. Do you think they manufactured their batch of nuvec there?

Yes we are not waiting the results of a trial which could go either way. Instead we are awaiting the results of a negotiation based on positive 9 month data etc and which AZ and N4p have tweeted they are co presenting on 13th feb- I will be annoyed with Nigel if he tweeted that without realising the implications

The deadline is tomorrow?

Btw the SPV is a great development but the Iran deal is still a long way off Lots of pieces of jigsaw to fit together before wsg get the heads up imho What concrete developments do we need to monitor which will indicate progress now that the SPV looks likely to be implemented? (PS don’t say secret talks via the EU or monitoring of trump facial expression- not concrete enough)

Imho The government official signing this off is deputy prime minister Netumbo Nandi-Ndaitwah, head of the special cabinet committee https://allafrica.com/stories/201811080588.html The mou with wsg was signed 22/11/15 but was cancelled when the Namibian president cancelled the HKIA upgrade and the associated Chinese loan The large Chinese loan has now been re-instated since sept 2018 A sticking point is resistance to foreign security involvement by the police and the 5 year MOU- imho a necessary formal agreement rushed in response to the icao audit in nov 2018 HKIA handles 940k pax- fits the size criteria Could be signed as part of the response to the icao audit in the next 60 days

The Hosea kutako upgrade begins March 19, with improvements in place by end of the year. Sign offs approved by government task force. Full Icao security audit report out late Jan with corrective action expected within 60 days We will need before and after satellite shots Who is volunteering?

Btw presenting at Bionow is also a step change. Nigel no longer has to be a jack of all trades presenting to care home residents in derby. It’s being presented and discussed by industry experts in a proper setting

If we get a tie up with medimmune, we will go from Nigel and a few diehard investors proclaiming its potential on this chat board to industry experts at large conferences and national journals discussing its worth. Inorganic nanopaticles have been slow to be translated to the clinic partly because they had to show critical advantage over the already established lipid nanoparticles. Nuvec May have shown enough promise to become once of the first, with big Pharma commiting the big investment required. It still early stage but then all inorganic nanoparticles for drug delivery are

They have until 31st Jan to secure exclusivity on the 9 month data. RNS to follow that?