RE: From the FT today12 Dec 2020 20:22
Genuine question, any medical type who knows the answer?
What causes test to fail? . Is it sampling was done poorly, maybe person blew nose, had a drink etc affecting antigen concentration ? Then again pcr picking up infection but that uses genetic material marker which gets amplified 30 times. Genetic material enclosed in cells, protected from drink, blowing nose etc. Does PCR release this protected material or is it only using “free virion”(is that what they are called).
LFD using antigen outside of cells, as virus particles or bits of. Does LFD open up cells to release that material to hit affimers or is that material in cells ignored.
Is the issue sensitivity or it that better info needed to ensure that antigen concentration is not compromised by a G and T 30 minutes before?
Also given the price if a test fails at 9am at 50% failure rate does that mean it’s 100% gonna fail at 6pm or does second test also have 50/50 chance given person has same state. Just throw tests at hot areas tell them to test least twice a day when they get up. 2 days in you’ll have sane chance as pcr as near as doesn’t matter, at a fraction of cost and hassle. Why the focus on test once and get in your merry way for days?
Is the answer for innovation to change the procedure, comparing apples to oranges otherwise.
Major issue is getting enough tests made for this approach :-) but given the money spent asking mates to get plastic aprons I don’t see how that can’t be solved, although making LFD machines harder than asking some bloke in China to send some pallets of gloves.
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