Member Info for tomvisual

Bella, yes. With AZN and GSK providing chemicals and with licencing deals we can ramp up production. Massive demand for world number one product. Hopefully, everyone will be applauding NCYTs stirling efforts.
I clapped for them last night.

Quickdraw, speed is one thing, accuracy another.
100% conformance to positive test cases is required. This is the conclusion I got from the 150 failed antibody test trials. Mutations need to be addressed.
The 100% homology and the daily monitoring for mutations is as VanV put it our golden goose.
As of 27th March 2020 PrimerDesign can comfirm 100% homology with the 1743 full length good quality SARS-CoV-2 sequences published on the GISAID EpiCoV database. Can any pther Company make this bold statement?

Yes. All countries vwill now be ramping up.
A sobering thought ....
Jeremy Bowen reported on the BBC (R4) this morning that one African country had 3 ventilators for the population! OMG. If test, test, test is the way out for everyone on the planet then massive overdrive in tes capacity required on a global scale, otherwise sadly herd immunity us their only option.
Where is leadership from WHO?? EU?

Wonder how good those FDA EUA approved product s are for 100%-conformance to positive test cases???

If PrimerDesign is the cornerstone for the new UK Diagnostic Capability, this is going to be massive.
Government will want to prevent this happening again.
Investment in Pharmas will be massive to built this world class capability (moreover after Brexit).
The 150 failed antibody tests indentified by Han**** gives an indication of the British rigour here for getting things right.
The whole of British Life Science Industry is being galvanised. We are lucky to be in at the start.
gla

VanV,
Government has looked at 150 antibody type tests and they do not work! Problem is a nit high quality test gives false assurance.
Looks like an in house solution is required!
PCR test is the only test in town!
Han**** on Today 8:10 (3/4/20) stated 100k all swab tests!
Tom Felden BBC Science Correspondent also mentioned that 100K per day tests can only be achieved with help of Thermo Fisher.
VanV our questions to RP on PCR tests just become more important!
I also wonder how accurate the US FDA EUA approved antibody tests are! FDA now reviewing FDA EUA applications. Other countries may have used FDA EUA as a proxy to quality.
Professor Whitty warned that the 'one thing worse than no test is a bad test". How true.
The whole of the British Life Science industry is being galvanised to test now by Han****.
Get me 100k/day by the end of April. That is the call.

9inch last nessage should have been in response to you not Codey.

Codey lets hope it stands up to the UKs scrutiny verification test.
Seems to me lots of Companies have developed antibody tests. However, what conformance to postive tests cases do these antibody tests provide. Reported on R4 Today that 150 antibody type tests have been reviewed. Non found to work!
If sone of these are FDA EUA approved then that begs the question on FDA EUA verification. Perhaps that is why FDA is now looking at these applications with more detail. Nothing worse than a rest that does NOT work. Same questions apply to PCR FDA EUA tests - Roche, Thermo Fisher and NCYT tests.
NCYT has 100% homology. Do the TF and Roche tests?
Take time to listen to the R4 program if you arecan investor in antibody shares.
See my previous message for time of the programme.
gla.

On R4 Today 6:32. Tom Feden reports that the Government has looked at 150 antibody type tests and they do not work!.
Looks like an in house solution is required!
PCR test is the only test in town!
Tom also mentioned that 100K per day tests can only be achieved with help of Thermo Fisher.
VanV our questions to RP on PCR tests just become more important!

I recall the IPO of Shire Pharmaceuticals. Look what happened to them!
Am I holding my shares for the longer term. Absolutely. For me, the bigger picture is what part does NCYT play in the UKs new diagnostic capability? Fascinating ...
gla.

Codey good point. However, other countries selecting the NCYT product may wish to see that NCYT have captured/major player in their home market. It gives the other countries confidence. Moreover, the UK is appearing to be very stringent in their assessments of the many tests available. This is a filter at the UKs cost, perhaps something that other countries value either on the basis of cost or given that they are unable to perform such verification. The UK had now down selected 3 PCR test products abd is still evaluating the antibody test.
I use the phrase appear as a chink in my argument is the Chinese test that we procured. Article in Guardian (3/4/30) indicates a mere 7.5 million tests. Are these the tests with 25% conformance with positive test cases? This figure is similar to the 30% figure Spain announced. Bottom line, a lot of money. Now once bitten twice shy PHE are being more thorough. I digress ...
Rule 1, never give up on a sale. Selling to 80 countries is great.
Rule2, capture/be a major player in your home market.
The science behind the NCYT test is unassailable and compelling and that is why it remains at the top of the assay table.
The UK's Primerdesign (PCR) test provides an 'unmatched [diagnostic] tool' which has '100% homology' with Covid-19 and is one of the most accurate available. As of 27th March 2020 PrimerDesign can comfirm 100% homology with the 1743 full length good quality SARS-CoV-2 sequences published on the GISAID EpiCoV database. Noone else is making this bold claim.
Additionally the FDA are now reviewing the FDA EUA's they granted. No one wants to us a bad test
Professor Whitty (uk) warned that the 'one thing worse than no test is a bad test". For me, all this puts NCYT in a strong position as a major player. Are we the cornerstone of the UKs new diagnostic capability. If we are then a little minnow from Southampton is about to join the premier league. Silver, hopefully we move from the AIM manipulative market!
gla

Bella,
I do not think there is a lack of lab tedting facilities in the UK. PHE opted for a centalised approach. This approach was not the one adopted in Germany. However, as they say we are where we are.... all facilities will now be utilised to provide the test requirements. Boris has spoken!

Obelix, would the Government allow this? Would the expertise required from PrimerDesign in the new Diagnostic capability of the UK not warrant a higher profile for PrimerDesign - moreover considering their experience with SARS, Ebola and covid 19 (a hat-trick)?
Would the Government not block a T/O by a non UK Company?

VanV, more research.Prof Peto's letter, Covid-19 mass testing facilities could end the epidemic rapidly.
Centrally organised facilities with the capacity to test the entire UK population weekly (in 6 days at 10 million tests per day) can be made available much more quickly and cheaply than a vaccine, probably within weeks.
Processing capacity equivalent to 4000 Roche COBAS 8800 systems is needed, and the UK may already have both the machines and the trained staff in post or immediately available.
That did sound quite optimistic at thevtime. Not tonight.
What was needed is some government coordination. Han**** now gets this.
So 60M tests minimum required.....
Prof Peto's paper at:
https://www.google.co.uk/url?sa=t&source=web&rct=j&url=https://www.bmj.com/content/bmj/368/bmj.m1163.full.pdf&ved=2ahUKEwjjkrSUtMroAhUFmVwKHVv8CM8QFjAAegQIBxAC&usg=AOvVaw0UX28ceh0yRKCC_0A-Q7Bb

Is this the direction of travel we are embarking on? 60M = £500M + sales.
Blair wanted 180M. Interesting ....
Follow the science ....
gla

Whats a hostage T/O?

100k/day=3M/ month.
Well within NCYT capability. Just needs to order.

100k tests per day across 5 pillars. May include but not limited by antibody tests.
Does this means antigen PCR swab tests. Yes. Most urgent!
gla

Routy1,
How many days at 10M tests/day?
UK with a population must be circa 75M.

VanV, as I suspect PHE to want to use their own test (from R4 Today broadcast) would this be a question for RP to ask?
Lead in would be:
Are PHE contempating using their own in-house test solution as opposed to the private sector for the supply of an antigen PCR test?
Followed by:
How does the PHE in-house test compare to the private sector tests in terms of percentage compliance to positive test cases, number of minutes (hours) before a test result is obtainable, homology against covid19 mutations and cost?

VanV,
it would be good to see from the PHE assessment how the the in-house PHE test faired against NYCT, TF, Roche ( or whoever the selected 3 are) , in terms of obtaining test result and conformance to positive test cases. Time is not on the UKs side.