Member Info for tomvisual

Why did Ophidian leave the BB?
Miss his detailed contributions.
We are all the poorer.

As we are all here to make money...
Wondering in the merit in discussing and collating a set of questions for the Q&A that isisomeone fo benefit to us all as a group that someone can forward to Share Talk?
Maximum 10 questions from all of us?
Not much time but at least we may be able to put some focus on our investment.

Jeremy Hunt (former Health Secretary) on R4 Today (around 7:53), stating
*70% of people do not show symptoms
* very quick large scale testing required
* Testing should be systematic, ie all secondary teachers tested once a week, taxi drivers (known high risk group).
* uk has 349k per day test capability (as of today), but only 180k tests are used.
* No technical difficulties to mass testing. There seems to be a hesitation by Govt. Worried about large symptomatic false positives. This could be addressed by a second test to confirm the positive test. (This was discussed on this BB by myself and others over the weekend!)

Come on Boris, form a decision and roll mass testing out.

Test, test, test

Doggy100, one stop shop courtesy of Arizona State University
https://chs.asu.edu/diagnostics-commons/testing-commons
Avacta have 2 tests.
Test, Test, Test

"you do need a trained health expert to do nasopharyngeal"
At the UK drive in test centres are individuals doing their own swab tests?
Test, test, test correctly

From
https://www.bmj.com/content/369/bmj.m1808/rr-22
False positives are a huge problem at low Prevalence, at the moment.
Still, I am a bit concerned about this comment in the rapid response:
"Large volume screening at a time of low prevalence has the potential to do more harm than good and some of these strategies should be temporarily suspended." That may, perhaps, be true, now, but things have to be done to make it no longer true.
It looks to me as if there is a need for multiple tests on each individual who tests positive, a bit like the Swansea people did in their investigation, including Antibody tests, to see if someone has recovered from Covid-19 but still has some residual traces, and multiple Antigen tests looking for different targets.
If Affimers can be easily engineered to look at different targets using a Lateral Flow test this should be done.
False negatives were a problem for the Swansea people and more generally. Doctors are frequently doing repeated tests on the same individual because they strongly suspect False Negative.
The Chinese, I recall from months ago, also looked for evidence from lung X-Ray as part of the diagnostic process. Perhaps people in the West should learn from this?
In conclusion, multiple tests that are as independent from each other as possible are possibly required. Obviously srarting with Awacta's!
Test, test, test

Vegas22 if Awactas test is £5 its cheaper to test for covid19 using our LFT. If you are negative you have the flu!
Additionally, NCYT are not selling into France as the French want a two gene test. The original PrimerDesign test assay had one gene. This new test assay is two gene so should open the French market to NCYT.
Test, test, test

Vegas some symptoms are similar.
See 11 symptoms of covid at

https://www.express.co.uk/life-style/health/1328464/coronavirus-uk-covid-symptoms-signs-full-list-infection-fever-cough

Johnht, what is the conversion to mg/ml.
Avogadros constant calculation?

Johnht do these links help

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7302192/

https://www.klinikum.uni-heidelberg.de/fileadmin/inst_hygiene/molekulare_virologie/Downloads/TCID50_calculator_v2_17-01-20_MB.xlsx

Test, test, test

Are we close to the lights out and away we go moment???
Belted and ready
Test, test, test

MoreorLess conclusion was 4.8%.

SDG27...
From MoreorLess,
"Generally out of 100 people only expect 1 to die"

Reposted here

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tomvisual

Posts: 751

Price: 203.00

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More Or Less R4 9am 26/8/20Today 09:50
Just listened to More or Less discussing convalescent blood plasma.
Trump and fda claim of prevention of 35 out of 100 deaths was wrong! Stephen Hahn admitted later he should have been referencing relative data rather than the absolute data.
Using absolute data 35 out of 100 less deaths claim reduced to 5 deaths out if 100 saved. WoW!!
This is terrible for FDA and Trump (who firced the issue). Good for SNG.
However, MoreorLess states that statistically out of 100 people you only expect 1 person to die.
Does this question the statistical conclusion and clarification in the previous SNG rns's?
The imbalance in patients with Diabetes and Cardio vascular disease is concerning to me.
More details need to be published about how corrections for baseline differences were made irrespective of trial results. The maths does not lie. For transparency, I would like to see the statistical data published for Peer Review scrutiny before the trial results!
Looks like more scrutiny of trial results even from the great fda is required!!
Test, test, test

Just listened to More or Less discussing blood plasma.
Trump and fda claim of prebvention of 35 out of 100 deaths was wrong! Stephen Hahn admitted later he should have been referencing relative data rather than the absolute data.
Using absolute data 35 out of 100 less deaths claim reduced to 5 deaths out if 100 saved. WoW!!
This is terrible for FDA and Trump (who firced the issue). Good for SNG.
However, MoreorLess states that statistically out of 100 people you only expect 1 person to die.
Does this question the statistical conclusion and clarification in the previous SNG rns's?
The imbalance in patients with Diabetes and Cardio vascular disease is concerning to me.
More details need to be published about how corrections for baseline differences were made irrespective of trial results. The maths does not lie. For transparency, I would like to see the statistical data published for Peer Review scrutiny before the trial results!
Test, test, test

Guardian reporting home test kits have run out
https://www.theguardian.com/world/2020/aug/24/coronavirus-home-test-kits-run-out-in-england-and-scotland

Thermofisher and Randox were initially supplying home test kits! No sure why the Primerdesign test has not been provided.
Test, test, test

Fda template for LFT
https://www.fda.gov/media/140615/download

Test, test, test

MHRA Guidelines
https://assets.publishing.service.gov.uk/government/uploads/system/uploads/attachment_data/file/895745/TPP_Point_of_Care_SARS-CoV-2_Detection_Tests.pdf

Table indicates desired UK requirement for clinical sens/spec of 97%/99% and acceptable 80%/95%.
Sona at 84.6%/90% does not make the requirements!
Klaus first attempt failed!
Test, test, test.

Morganfreeman, 8k...
I assume comparison with television resolution.

Can someone please remind me what Spna originally claimed on Sensitivity and Specificity?
I think I recall reading 96%, 96%!
Sona clinical tests now indicating
sensitivity of 84.6% and a specificity of 90.0% in a study across 99 collected clinical patient samples.
Test, test, test