Member Info for tomvisual

Daily Mail reporting on NudgeBox
https://www.dailymail.co.uk/news/article-8745591/The-90-minute-coronavirus-test-thats-94-accurate.html
94%, Accuracy.
16 tests per day (24 hours) per machine!

Well Paraytec and Sheffield University are have a 5 minute test in development!
Test, test, test

A simple tweet from the guys at the coal face advising that we are on target/schedule could cause a major boost to the share price!
Come on Sheffield University and Paraytec!
Test, test, test

There are lots of pitfalls on yvevriad to No1. Avacta having problems with tooling! So their test may not be ready till December!
Other test assays (PCR) have issues with reagent availability.
This could be an interesting investment!
Test, test, test

If they have proof of concept, the national emergency may come to the fore. Govt has a £100B war chest to get the economy of the country moving.
Look what happened to ventilators.
We as a nation are short of tests!
5minute test solution. Whats not to like!
Test, test, test

See the previous RNS for anticipated completion, October 2020!
Test, test, test

Dunno, look at the website
The objective is to develop a portable test, which can generate a result in a matter of minutes from a swab provided at the test location and which requires no specialist skills for its operation

The resultant fluorescent signal is measured by the DETECTION module using a version of our Actipix area imaging technology configured for fluorescence detection.

https://www.selectscience.net/products/actipix-d100-uv-area-imaging-system/?prodID=14184#tab-2

Peptide limit of quantification: 100 ng / ml (190 nm) = 100pg/ul.

UV imaging
https://www.paraytec.com/docs/335/insights-into-the-early-dissolution-events-of-amlodipine.pdf

https://www.paraytec.com/docs/325/realtime-uv-imaging-of-nicotine-release-from-transdermal.pdf

CMOS sensor
https://www.spectroscopyonline.com/view/cmos-technology-scientific-imaging

Looking at the references, Paraytec certainly has some wonderful equipment for research.
The question is the application to fast and large scale testing.
If they can crack this then ......
Stick with this as a lot of RNS are due to land as the WP milestones are met!
Test, test, test

Where the prevalence is lower, and Ct values are lower, I wonder if the instrument calibration can be adjusted to provide an enhanced Pass/Fail criterion which may be difficult to achieve with other mass testing methods, i.e. a Lateral Flow Test ( LFT). https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7325181/pdf/nihpp-2020.06.22.20136309.pdf

We await the Proof of Concept shortly!
Test, test, test

IsthisaWinner, No.
For WP1, to avoid using live Coronavirus in the lab during proof of concept, an artificial version of the virus is used.
Just making the point that if you have a PCR instrument at the University then this is a major tick in the box along the road of comparablity against the known "gold standard" approach.
For final validation (if required), you can validate results of the PCR test assay result with the Paraytec/Sheffield University instrumentation . This is the ultimate proof of concept that the Paraytec/SU instrument sensitivity and specificity and hence accuracy is comparable.
Then bingo!
Test, test, test.

Isthisawinner, the tender does not involve us, but it may allow Sheffield University access to a PCR machine to allow final validation of the Paraytec/Sheffield University proof of concept .

Seems to me Medusa is more a liability than an asset to Dr AS. This is the second time intervention has been required from Avacta, diluting the Company focus on priorities.
Test, test, test

Sheffield University have raised a tender for a Polymerase Chain Reaction (PCR) machine capable of high throughput digital PCR and qPCR.
http://bidstats.uk/tenders/2020/W37/734462082

Hopefully, this gives also gives Sheffield University the ability validate the work done by the University and Paraytec
Test, test, test

Well done to this BB for highlighting the fake news article.

How can you misrepresent £ for p in a financial article in numerous places.
Must be fake news.

How can you misrepresent £ for p in a financial article in numerous places.
Must be fake news.

https://uk.linkedin.com/in/charlie-oliver-bingham-95185847
Bingham is potentially an analyst at Goldman Sachs not Schroder!

From RNS Number : 5776R
Braveheart Investment Group plc
30 June 2020

RMS has two trading subsidiaries, GyroMetric Systems Limited ("GyroMetric"), in which it owns a 58 per cent. interest, which develops and manufactures digital monitoring and safeguarding systems for rotating shafts and Cloudveil Limited ("Cloudveil"), an intelligence services and security risk management business, which was acquired in September 2019.

Braveheart has a 19.5 per cent. interest in Gyrometric.

The information impacts covid stocks and is more important than the poster!
Test, test, test

If Cytiva having the tooling then surely the same tooling can be used to all manufacturers?
Uou only need one set of tooling. Unless the UK Govt have indeed requested amendments to the test assay that had implications to the ecisting tooling.
Test, test, test

Telegraph reporting that pooled testing to be used to help Government hit 'moonshot' target
Method involves combining small amounts of all coronvairus test swabs in a batch into single test tube, saving time and resources.
https://www.telegraph.co.uk/politics/2020/09/15/pooled-testing-used-help-government-hit-moonshot-target/

Ministers plan to hit their controversial "moonshot" target to conduct 10 million tests a day by combining up to 50 samples for a single result.

The method, known as pooled testing, involves combining small amounts of all the swabs in a batch into a single test tube.

If Covid-19 is not detected in the composite sample, all patients are deemed negative. If any virus is found, all original swabs are then tested individually.

The technique intended to save time and scarce resources, would enable Boris Johnson to claim victory in his highly ambitious plan, announced earlier this month, while having physically tested only a fraction of the declared daily results.

All testing availability required in this next 2-3 months to overcome backlog and Winter second wave. Paraytec can hopefully bring their test to assist with the ongoing situation of test shortages.
Test, test, test

Telegraph reporting that pooled testing to be used to help Government hit 'moonshot' target
Method involves combining small amounts of all coronvairus test swabs in a batch into single test tube, saving time and resources.
https://www.telegraph.co.uk/politics/2020/09/15/pooled-testing-used-help-government-hit-moonshot-target/

Ministers plan to hit their controversial "moonshot" target to conduct 10 million tests a day by combining up to 50 samples for a single result.

The method, known as pooled testing, involves combining small amounts of all the swabs in a batch into a single test tube.

If Covid-19 is not detected in the composite sample, all patients are deemed negative. If any virus is found, all original swabs are then tested individually.

The technique intended to save time and scarce resources, would enable Boris Johnson to claim victory in his highly ambitious plan, announced earlier this month, while having physically tested only a fraction of the declared daily results.